Research progress on obesity and central nervous system regulation

doi:10.3877/cma.j.issn.2095-9605.2024.02.006

Abstract

Abstract:

Obesity is a pathological state caused by long-term energy imbalance and has become a major global public health issue. The central nervous system (CNS) plays a crucial role in maintaining energy balance, directly influencing body weight by regulating food intake and energy expenditure. In recent years, the significance of the brain-gut axis in obesity research has become increasingly prominent. Gut peptides interact with receptors in the brain, affecting CNS function. This article reviews the homeostatic and hedonic systems in the CNS that regulate eating, discusses the role of the hypothalamus in regulating energy expenditure, and describes how gut peptides and microbiota in the brain-gut axis influence CNS regulation of food intake and the changes in the brain-gut axis after weight loss surgery, offering new research perspectives for the prevention and treatment of obesity.

Key words: Central nervous system, Obesity, Energy balance, Metabolic and bariatric surgery

Wanjie Wang, Wenchao Song, Jian Wang, Liangchen Ni, Jian Hong, Xiaocheng Zhu, Libin Yao. Research progress on obesity and central nervous system regulation[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(02): 108-112.

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References 33

[1]	国家卫生健康委疾病预防控制局. 中国居民营养与慢性病状况报告(2020年) [M]. 北京: 人民卫生出版社, 2021.
[2]	范晓轩, 王娜, 朱丽花, 等. 肥胖相关肿瘤研究进展 [J/CD]. 中华肥胖与代谢病电子杂志, 2023, 9(3): 173-178.
[3]	Jais A, Brüning JC. Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus [J]. Endocrine Reviews, 2022, 43(2): 314-328.
[4]	Deem JD, Faber CL, Morton GJ. AgRP neurons: Regulators of feeding, energy expenditure, and behavior [J]. FEBS J, 2022, 289(8): 2362-2381.
[5]	Brüning JC, Fenselau H. Integrative neurocircuits that control metabolism and food intake [J]. Science, 2023, 381(6665): eabl7398.
[6]	Chen Y, Essner RA, Kosar S, et al. Sustained NPY signaling enables AgRP neurons to drive feeding [J]. Elife, 2019, 8: e46348.
[7]	Quarta C, Claret M, Zeltser LM, et al. POMC neuronal heterogeneity in energy balance and beyond: an integrated view [J]. Nat Metab, 2021, 3(3): 299-308.
[8]	Cabral A, Fernandez G, Tolosa MJ, et al. Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus, in a growth hormone secretagogue receptor-dependent manner [J]. Mol Metab, 2020, 32: 69-84..
[9]	Li MM, Madara JC, Steger JS, et al. The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits [J]. Neuron, 2019, 102(3): 653-667. e6.
[10]	Varela L, Horvath TL. Parallel Paths in PVH Control of Feeding [J]. Neuron, 2019, 102(3): 514-516.
[11]	Liu CM, Spaulding MO, Rea JJ, et al. Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms [J]. Int J Mol Sci, 2021, 22(19): 10859.
[12]	Qiu W, Hutch CR, Wang Y, et al. Multiple NTS neuron populations cumulatively suppress food intake [J]. Elife, 2023, 12: e85640.
[13]	sang AH, Nuzzaci D, Darwish T, et al. Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons [J]. Mol Metab, 2020, 42: 101070.
[14]	Chen J, Cheng M, Wang L, et al. A Vagal-NTS Neural Pathway that Stimulates Feeding [J]. Curr Biol, 2020, 30(20): 3986-3998. e5.
[15]	Woodward ORM, Gribble FM, Reimann F, et al. Gut peptide regulation of food intake- evidence for the modulation of hedonic feeding [J]. J Physiol, 2022, 600(5): 1053-1078.
[16]	Marcos JL, Olivares-Barraza R, Ceballo K, et al. Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake [J]. Int J Mol Sci, 2023, 24(2): 1468.
[17]	Rossi MA, Stuber GD. Overlapping Brain Circuits for Homeostatic and Hedonic Feeding [J]. Cell Metab, 2018, 27(1): 42-56.
[18]	Tran LT, Park S, Kim SK, et al. Hypothalamic control of energy expenditure and thermogenesis [J]. Exp Mol Med, 2022, 54(4): 358-369.
[19]	Zink AN, Bunney PE, Holm AA, et al. Neuromodulation of orexin neurons reduces diet-induced adiposity [J]. Int J Obes (Lond), 2018, 42(4): 737-745.
[20]	Ruocco C, Malavazos AE, Ragni M, et al. Amino acids contribute to adaptive thermogenesis. New insights into the mechanisms of action of recent drugs for metabolic disorders are emerging [J]. Pharmacol Res, 2023, 195: 106892.
[21]	Liu J, Lin L. Small molecules for fat combustion: targeting thermosensory and satiety signals in the central nervous system [J]. Drug Discov Today, 2019, 24(1): 300-306.
[22]	Wachsmuth HR, Weninger SN, Duca FA. Role of the gut–brain axis in energy and glucose metabolism [J]. Experimental & Molecular Medicine, 2022, 54(4): 377.
[23]	Cui H, López M, Rahmouni K. The cellular and molecular bases of leptin and ghrelin resistance in obesity [J]. Nature Reviews. Endocrinology, 2017, 13(6): 338-351.
[24]	Al Massadi O, Nogueiras R, Dieguez C, et al. Ghrelin and food reward [J]. Neuropharmacology, 2019, 148: 131-138.
[25]	Trapp S, Brierley DI. Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment [J]. Br J Pharmacol. 2022, 179(4): 557-570.
[26]	Oertel M, Ziegler CG, Kohlhaas M, et al. GLP-1 and PYY for the treatment of obesity: a pilot study on the use of agonists and antagonists in diet-induced rats [J]. Endocrine Connections, 2024, 13(3): e230398.
[27]	Alonso AM, Cork SC, Phuah P, et al. The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake [J]. Molecular Metabolism, 2024, 81: 101895.
[28]	Gupta A, Osadchiy V, Mayer EA. Brain-gut-microbiome interactions in obesity and food addiction [J]. Nat Rev Gastroenterol Hepatol, 2020, 17(11): 655-672.
[29]	de Wouters d'Oplinter A, Rastelli M, Van Hul M, et al. Gut microbes participate in food preference alterations during obesity [J]. Gut Microbes, 2021, 13(1): 1959242.
[30]	Gao K, Mu CL, Farzi A, et al. Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain [J]. Adv Nutr, 2020, 11(3): 709-723.
[31]	刘金钢. 减重手术术式选择及对机体代谢的调节 [J]. 肠外与肠内营养, 2020, 27(1): 1-4.
[32]	Custers E, Franco A, Kiliaan AJ. Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation [J]. J Inflamm Res, 2023, 16: 5495-5514.
[33]	Gasmi A, Bjørklund G, Mujawdiya PK, et al. Gut microbiota in bariatric surgery [J]. Crit Rev Food Sci Nutr, 2023, 63(28): 9299-9314.

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