Abstract:

The relationship between obesity and the development of osteoarthritis is usually explained as the result of excessive joint strain caused by overweight. Previous studies put forward the hypothesis of metabolic osteoarthritis, and suggested that fat metabolism and intestinal microorganisms are important factors mediating the progress of osteoarthritis. Various inflammatory factors in patients with metabolic syndrome are up-regulated, including phospholipase A2, leptin, adiponectin, serum resistin, chemokine and serine protease inhibitor, which affect the progression of osteoarthritis by regulating various inflammatory pathways. The imbalance of enteric microorganisms can also affect the metabolism of articular cartilage and tissues around joints in many ways, thus affecting joint inflammation and cartilage changes and mediating the development of arthritis. This paper points out the research progress on the relationship between obesity fat metabolism, abnormal intestinal microflora and osteoarthritis, and provides new ideas and directions for the prevention and treatment of obesity-related osteoarthritis.

Key words: Obesity, Osteoarthritis, Fat factor, Microorganisms, Inflammation, Metabolism