Theresearch progress on the involvement of mitochondria in the occurrence and development of T2DM

doi:10.3877/cma.j.issn.2095-9605.2022.03.001

Abstract

Abstract:

Type 2 diabetes mellitus (T2DM) is the most prevalent type of diabetes. T2DM is predominantly caused by tissue insensitivity to insulin action (insulin resistance) accompanied by insufficient insulin secretion. Its pathophysiological mechanism is still unclear. The latest research shows that mitochondria, as the center of cellular energy metabolism, whose abnormal structure and function play an important role in the occurrence and development of T2DM. This review mainly reviews the signaling pathway mechanism of abnormal mitochondrial function involved in T2DM, and the effects of current first-line hypoglycemic drugs on mitochondrial morphology and function. This article aims to provide an important basis for elucidating the molecular mechanism of T2DM and developing new clinical strategies by targeting mitochondria.

Key words: Mitochondria, Type 2 diabetes mellitus, Antidiabetic drugs

Ze Li, Hui Liu, Xueyin Pu, Bozhi Liu, Feifei Wu, Yanling Yang, Yayun Wang. Theresearch progress on the involvement of mitochondria in the occurrence and development of T2DM[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(03): 147-153.

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References 54

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