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中华肥胖与代谢病电子杂志 ›› 2023, Vol. 09 ›› Issue (01) : 43 -49. doi: 10.3877/cma.j.issn.2095-9605.2023.01.009

综述

减重代谢手术后机体改变的脑–肠–菌轴机制研究进展
孙永兵, 周菁, 温东朋, 和俊雅, 林新贝, 乔琦, 李中林, 张诚, 王志凯, 张建成, 武肖玲, 邹智, 王勇, 李永丽()   
  1. 450003 郑州,郑州大学人民医院医学影像科
    河南省慢病健康管理重点实验室
    河南省人民医院胃肠外科
    河南大学人民医院医学影像科
    河南省人民医院核医学科
    河南省人民医院全科医学科
    河南省人民医院健康管理学科河南省慢病健康管理重点实验室
  • 收稿日期:2022-12-10 出版日期:2023-02-28
  • 通信作者: 李永丽
  • 基金资助:
    河南省中青年卫生健康科技创新人才项目(YXKC2020004); 国家自然科学基金项目资助(82071884); 河南省科技厅科技攻关项目(222102310198); 河南省医学科技攻关计划项目(LHGJ20200060)

Research progress of brain-enteric-bacterial axis mechanism in weight-loss metabolic surgery

Yongbing Sun, Jing Zhou, Dongpeng Wen, Junya He, Xinbei Lin, Qi Qiao, Zhonglin Li, Cheng Zhang, Zhikai Wang, Jiancheng Zhang, Xiaoling Wu, Zhi Zou, Yong Wang, Yongli Li()   

  1. Medical Imaging Department, People's Hospital of Zhengzhou University
    Henan Key Laboratory of Chronic Disease Health Management
    Department of Gastrointestinal Surgery, Henan Provincial People's Hospital
    Department of Medical Imaging, People's Hospital of Henan University
    Department of Nuclear Medicine, Henan Provincial People's Hospital
    Department of General Medicine, Henan Provincial People's Hospital
    Key Laboratory of Chronic Disease Health Management of Henan Province, Department of Health Management, Henan Provincial People's Hospital, Zhengzhou 450003, China
  • Received:2022-12-10 Published:2023-02-28
  • Corresponding author: Yongli Li
引用本文:

孙永兵, 周菁, 温东朋, 和俊雅, 林新贝, 乔琦, 李中林, 张诚, 王志凯, 张建成, 武肖玲, 邹智, 王勇, 李永丽. 减重代谢手术后机体改变的脑–肠–菌轴机制研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2023, 09(01): 43-49.

Yongbing Sun, Jing Zhou, Dongpeng Wen, Junya He, Xinbei Lin, Qi Qiao, Zhonglin Li, Cheng Zhang, Zhikai Wang, Jiancheng Zhang, Xiaoling Wu, Zhi Zou, Yong Wang, Yongli Li. Research progress of brain-enteric-bacterial axis mechanism in weight-loss metabolic surgery[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2023, 09(01): 43-49.

肥胖症是一种全球流行病并造成巨大的社会和经济负担。减重代谢手术(BMS)作为治疗肥胖症最有效的方法,其机制一直被探索。越来越多的临床研究证实脑−肠−菌轴在肥胖的病理生理学机制中发挥重要作用,但目前缺少该领域的综述。本文对肥胖患者BMS术后神经系统、代谢、内分泌、免疫系统和微生物群组改变的脑−肠−菌轴机制进行综述,以期阐明BMS治疗肥胖的机理并为肥胖症患者术后体重管理提供相关依据与参考。

Obesity is a global epidemic with enormous social and economic burdens. Bariatric metabolic surgery (BMS) is the most effective treatment for obesity, and its mechanism has been explored. More and more clinical studies have confirmed that the brain-enteric-bacterial axis plays an important role in the pathophysiological mechanism of obesity, but there is a lack of review in this field. In this paper, the brain-entero-bacterial axis mechanism of changes in the nervous system, metabolism, endocrine system, immune system and microbial group in patients with obesity after BMS was reviewed, in order to clarify the mechanism of BMS treatment for obesity and provide relevant basis and reference for postoperative weight management in patients with obesity.

图1 脑−肠−菌轴作用机制
图2 BMS术后机体改变
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