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中华肥胖与代谢病电子杂志 ›› 2024, Vol. 10 ›› Issue (02) : 88 -93. doi: 10.3877/cma.j.issn.2095-9605.2024.02.003

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GLP-1受体激动剂——司美格鲁肽的应用及安全性
颜宥彤1, 赵锐1, 万谦益1, 张贵祥1, 沈弘毅1, 程中1, 陈亿1,()   
  1. 1. 610041 成都,四川大学华西医院胃肠外科减重外科中心
  • 收稿日期:2024-03-07 出版日期:2024-05-30
  • 通信作者: 陈亿

GLP-1 receptor agonist—application and safety of semaglutide

Youtong Yan1, Rui Zhao1, Qianyi Wan1, Guixiang Zhang1, Hongyi Shen1, Zhong Cheng1, Yi Chen1,()   

  1. 1. Bariatic Surgery Center, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2024-03-07 Published:2024-05-30
  • Corresponding author: Yi Chen
引用本文:

颜宥彤, 赵锐, 万谦益, 张贵祥, 沈弘毅, 程中, 陈亿. GLP-1受体激动剂——司美格鲁肽的应用及安全性[J]. 中华肥胖与代谢病电子杂志, 2024, 10(02): 88-93.

Youtong Yan, Rui Zhao, Qianyi Wan, Guixiang Zhang, Hongyi Shen, Zhong Cheng, Yi Chen. GLP-1 receptor agonist—application and safety of semaglutide[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(02): 88-93.

目前肥胖症治疗方法包括生活方式干预、药物治疗和减重代谢手术,但非手术策略难以使大多数患者体重持续下降。新兴的GLP-1受体激动剂(GLP-1RAs)司美格鲁肽作为一种得到证实的对肥胖症以及糖尿病等疾病具有良好治疗效果的药物,通过激活下丘脑内的GLP-1受体,调节食欲并延迟肠胃排空。但其不良反应包括低血糖、胆石症、急性胰腺炎、自伤及自杀风险增高等,现已均有报道。未来研究应进一步涵盖更多元化的人群,并开展针对中国人群的大型随机对照试验以更好地完善临床应用。本文总结了司美格鲁肽在肥胖症慢性体重管理中的作用机制、体重减轻疗效及安全性。

Current treatments for obesity include lifestyle interventions, pharmacotherapy, and bariatric metabolic surgery. However, non-surgical strategies often fail to sustain weight loss for most patients. The emerging glucagon-like peptide 1 receptor agonists (GLP-1RAs), semaglutide, has been proven effective in treating obesity and diseases such as diabetes. It works by activating GLP-1 receptors in the hypothalamus, regulating appetite, and delaying gastric emptying. However, adverse effects such as hypoglycemia, cholelithiasis, acute pancreatitis, and increased risks of self-harm and suicide have been reported. Future research should include more diverse populations and conduct large-scale randomized controlled trials targeting the Chinese population to better refine clinical applications. This review summarizes the mechanisms, weight loss efficacy, and safety of semaglutide in chronic weight management for obesity.

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