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中华肥胖与代谢病电子杂志 ›› 2023, Vol. 09 ›› Issue (01) : 50 -54. doi: 10.3877/cma.j.issn.2095-9605.2023.01.010

综述

脂质运载蛋白2在肥胖症及相关疾病中的作用研究进展
张金娜, 盖家宁, 李影()   
  1. 225001 扬州,江苏省苏北人民医院内分泌科
  • 收稿日期:2023-02-03 出版日期:2023-02-28
  • 通信作者: 李影
  • 基金资助:
    江苏省苏北人民医院博士启动基金(BSQDJ0059)

Research progress of Lipocalin-2 in obesity and related diseases

Jinna Zhang, Jianing Gai, Ying Li()   

  1. Department of Endocrinology, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, China
  • Received:2023-02-03 Published:2023-02-28
  • Corresponding author: Ying Li
引用本文:

张金娜, 盖家宁, 李影. 脂质运载蛋白2在肥胖症及相关疾病中的作用研究进展[J]. 中华肥胖与代谢病电子杂志, 2023, 09(01): 50-54.

Jinna Zhang, Jianing Gai, Ying Li. Research progress of Lipocalin-2 in obesity and related diseases[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2023, 09(01): 50-54.

脂肪因子在肥胖、胰岛素抵抗、糖尿病等慢性代谢性炎症疾病中发挥着重要作用。脂质运载蛋白2(LCN2)也称为中性粒细胞明胶酶相关的脂蛋白,是一种25 kDa的分泌性糖蛋白,属于脂蛋白超家族一员,广泛表达于多种组织和细胞中,包括脂肪细胞、肝细胞、肾小管细胞和成骨细胞等。它具有维持铁稳态、促进上皮细胞分化、参与免疫反应调节等作用。揭示LCN2与肥胖、糖尿病及相关疾病之间的关系,将有助于为代谢性疾病的防治提供新的靶点和思路。

Adipokines play an important role in chronic metabolic and inflammatory diseases such as obesity, insulin resistance, and diabetes. Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin, is a 25-kDa secretory glycoprotein that belongs to the lipocalin superfamily. LCN2 is widely expressed invarioustissues and cells, including adipocytes, hepatocytes, renal tubular cells, and osteoblasts. LCN2 is involved in maintaining iron homeostasis, promoting epithelial cell differentiation, and regulating immune responses. Revealing the relationship between LCN2 and obesity, diabetes and related diseasesmay provide new targets and ideas for the prevention and treatment of metabolic diseases.

图1 LCN2对代谢性疾病的调控作用
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