Relationship between intrauterine growth retardation and neonatal blood glucose and lipid metabolism

doi:10.3877/cma.j.issn.2095-9605.2019.01.005

Abstract

Abstract:

Objective

To investigate the effects of intrauterine growth retardation on neonatal blood glucose and lipid metabolism.

Methods

A total of 113 neonates (IUGR group) diagnosed with IUGR at the Jieyang People's Hospital from March 2016 to February 2018 were retrospectively analyzed. A total of 80 non-IUGR neonates were selected as controls. To compare the postnatal physical development indicators, blood glucose and blood lipid indicators, and insulin sensitivity and resistance in the two groups of newborns. The ISI index of the IUGR group was significantly lower than that of the non-IUGR group, and the difference was statistically significant (t=4.317, P<0.001).

Results

The birth weight, length, head circumference, waist circumference, and weight/length of the newborns in the IUGR group were significantly lower than those in the non-IUGR group. There were no significant differences in FG, TG and TC levels between the IUGR group and the non-IUGR group (P>0.05). The ISI index of the IUGR group was significantly lower than that of the non-IUGR group, and the difference was statistically significant (t= 4.317, P<0.001). The HOMA-IR index of the IUGR group was significantly higher than that of the non-IUGR group (t=4.013, P<0.001). There was no significant correlation between the birth weight of newborns and FG, TG and TC levels (P>0.05), but a significant positive correlation with ISI index (r=0.479, P<0.001), and HOMA-IR. The number showed a significant negative correlation (r=-0.642, P<0.001).

Conclusions

IUGR neonates have decreased insulin sensitivity, increased insulin resistance, and their birth weight is closely related to insulin sensitivity and resistance.

Key words: Intrauterine growth restriction, Birth weight, Blood sugar, Blood lipids, Insulin

Chuangting Lin, Songyao Lu, Xiang Huang, Shaozhen Guo. Relationship between intrauterine growth retardation and neonatal blood glucose and lipid metabolism[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2019, 05(01): 26-30.

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Figures/Tables 5

References 15

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组别	n(例)	胎龄(周)	母亲年龄(岁)	性别(男/女)	剖宫产(%)
IUGR组	113	36.4±2.1	29.4±2.7	54/59	34(30.1)
非IUGR组	80	36.6±2.3	28.9±2.2	42/38	25(31.3)
χ²/t值	?	0.626	1.366	0.416	0.030
P值	?	0.532	0.174	0.519	0.863

组别	n(例)	胎龄(周)	母亲年龄(岁)	性别(男/女)	剖宫产(%)
IUGR组	113	36.4±2.1	29.4±2.7	54/59	34(30.1)
非IUGR组	80	36.6±2.3	28.9±2.2	42/38	25(31.3)
χ²/t值	?	0.626	1.366	0.416	0.030
P值	?	0.532	0.174	0.519	0.863

组别	n(例)	出生体重(g)	身长（cm）	头围（cm）	腹围（cm）	体重/身长(g/cm)
IUGR组	113	2126.7±184.6	45.3±2.1	30.7±1.4	31.5±2.3	46.9±3.6
非IUGR组	80	2608.4±225.3	46.2±2.5	31.4±1.2	32.6±2.1	60.8±5.8
t值	?	16.286	2.709	3.627	3.392	20.510
P值	?	<0.001	0.007	<0.001	0.001	<0.001

组别	n(例)	出生体重(g)	身长（cm）	头围（cm）	腹围（cm）	体重/身长(g/cm)
IUGR组	113	2126.7±184.6	45.3±2.1	30.7±1.4	31.5±2.3	46.9±3.6
非IUGR组	80	2608.4±225.3	46.2±2.5	31.4±1.2	32.6±2.1	60.8±5.8
t值	?	16.286	2.709	3.627	3.392	20.510
P值	?	<0.001	0.007	<0.001	0.001	<0.001

组别	n(例)	FG (mmol/L)	TG(mmol/L)	TC(mmol/L)
IUGR组	113	4.63±0.91	1.14±0.44	3.72±0.84
非IUGR组	80	4.47±1.22	1.22±0.51	3.83±0.52
t值	?	1.043	1.164	1.038
P值	?	0.298	0.246	0.300

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