肥胖与甲状腺癌之间存在显著相关性，目前针对肥胖合并甲状腺癌的治疗方案的研究和文献相对有限。本文报告了1例31岁女性患者，因体检发现胰岛素抵抗及甲状腺肿瘤3 d后入院。患者体质量110 kg，BMI 38.5 kg/m²，辅助检查显示抗甲状腺过氧化物酶抗体升高，甲状腺超声提示双叶甲状腺结节，结合穿刺结果考虑甲状腺癌可能。在上海交通大学医学院附属第六人民医院减重代谢外科的多学科团队协作下，患者成功接受了单孔腹腔镜袖状胃切除术联合经颏下前庭腔镜下甲状腺癌根治术的一期手术治疗。手术时间为205 min，患者术后恢复顺利，无明显并发症。此治疗方案展现了减少多次麻醉和住院需求的优势，同时满足患者对美观和快速康复的需求，为肥胖合并甲状腺癌患者的治疗提供了新的选择。

The incidence of both obesity and thyroid cancer is rising worldwide，and obesity has become an important risk factor for thyroid cancer.Studies have shown a significant correlation between obesity and thyroid cancer； however，treatment strategies for patients with both conditions are currently under-researched.This case report describes a 31-year-old female patient admitted to the hospital after a routine check-up detected insulin resistance and a thyroid tumor three days prior.The patient had a body weight of 110 kg and a body mass index （BMI） of 38.5 kg/m².Auxiliary examinations revealed elevated antithyroid peroxidase antibody （TPOAb） levels，and thyroid ultrasound showed bilateral thyroid nodules，with a suspicion of thyroid cancer based on fine-needle aspiration results.A multidisciplinary team at the Department of Bariatric and Metabolic Surgery，Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine successfully performed a single-port laparoscopic sleeve gastrectomy combined with a transoral endoscopic thyroidectomy vestibular approach for thyroid cancer in a single-stage procedure.The surgery lasted 205 minutes，and the patient had an uneventful recovery without significant complications.This combined approach effectively reduced the need for multiple anesthesia and hospital admissions while meeting the patient's needs for cosmetic outcomes and rapid recovery，offering a novel treatment option for patients with obesity and thyroid cancer.