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中华肥胖与代谢病电子杂志 ›› 2025, Vol. 11 ›› Issue (01) : 19 -25. doi: 10.3877/cma.j.issn.2095-9605.2025.01.003

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新型减重药物的研究进展
王文博1, 曹耀权1, 朱利勇1,()   
  1. 1. 410013 长沙,中南大学湘雅三医院减重与代谢外科
  • 收稿日期:2024-11-01 出版日期:2025-02-28
  • 通信作者: 朱利勇
  • 基金资助:
    国家自然科学基金面上项目(No.82370676)湖南省卫生健康委员会重点项目(No.202104010349)

Recent developments in novel anti-obesity medications

Wenbo Wang1, Yaoquan Cao1, Liyong Zhu1,()   

  1. 1. Department of Bariatric Metabolic Surgery,the Third Xiangya Hospital,Central South University,Changsha 410013,China
  • Received:2024-11-01 Published:2025-02-28
  • Corresponding author: Liyong Zhu
引用本文:

王文博, 曹耀权, 朱利勇. 新型减重药物的研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2025, 11(01): 19-25.

Wenbo Wang, Yaoquan Cao, Liyong Zhu. Recent developments in novel anti-obesity medications[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2025, 11(01): 19-25.

肥胖已成为全球重大公共卫生挑战,其患病率的不断上升,且并发症频发,给医疗系统带来沉重负担,亟需有效治疗策略。当前市场上获批的减重药物稀缺且疗效有限,多种新型减重药物,如多受体激动剂及针对新靶点的药物,正处于研发或临床试验阶段。本文综述了这些新型药物的分类、潜在作用机理、疗效评估及安全性考量,为临床减重治疗提供了重要参考,旨在开辟肥胖治疗的新途径与选择。

Obesity has emerged as a significant global public health challenge,with its increasing prevalence and frequent complications placing a heavy burden on healthcare systems.Effective treatment strategies are urgently needed.Currently approved weight-loss medications are scarce and have limited efficacy,while various novel weight-loss drugs,such as multi-receptor agonists and drugs targeting new pathways,are in various stages of research and clinical trials.This review categorizes these new drugs,discusses their potential mechanisms of action,evaluates their efficacy,and considers safety implications,providing crucial insights for clinical weight-loss treatments.The aim is to pave the way for new approaches and options in the treatment of obesity.

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