[1] |
世界肥胖联盟.2024年世界肥胖报告 [EB/OL].伦敦:世界肥胖联盟,2024.https://data.worldobesity.org/publications/?cat=22
|
[2] |
Peng W,Chen SQ,Chen XG,et al.Trends in major noncommunicable diseases and related risk factors in China 2002-2019:an analysis of nationally representative survey data [J].Lancet Reg Health West Pac,2024 ,43:100809.
|
[3] |
心洁,壹图.《中国居民营养与慢性病状况报告(2020年)》国务院新闻办公室2020年12月23日新闻发布会(摘要) [J].中老年保健,2021,31(02):14-21.
|
[4] |
Garvey WT,Mechanick JI,Brett EM,et al.American association of clinical endocrinologists and American college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity [J].Endocr Pract,2016,22(7):842-884.
|
[5] |
Evert AB,Dennison M,Gardner CD,et al.Nutrition therapy for adults with diabetes or prediabetes:a consensus report [J].Diabetes Care,2019,42(5):731-754.
|
[6] |
Wing RR,Lang W,Wadden TA,et al.Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes [J].Diabetes Care,2011,34(7):1481-1486.
|
[7] |
Look AHEAD Research Group,Gregg EW,Jakicic JM,Blackburn G,et al.Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes:a post-hoc analysis of the look AHEAD randomised clinical trial [J].Lancet Diabetes Endocrinol,2016,4(11):913-921.
|
[8] |
Hall KD,Kahan S.Maintenance of lost weight and long-term management of obesity [J].Med Clin North Am,2018,102(1):183-197.
|
[9] |
Horn DB,Almandoz JP,Look M.What is clinically relevant weight loss for your patients and how can it be achieved? A narrative review[J].Postgrad Med,2022,134(4):359-375.
|
[10] |
Gloy VL,Briel M,Bhatt DL,et al.Bariatric surgery versus nonsurgical treatment for obesity:a systematic review and meta-analysis of randomised controlled trials [J].BMJ,2013,125:461.
|
[11] |
中华医学会内分泌学会.肥胖患者的长期体重管理及药物临床应用指南(2024版) [J].中华内分泌代谢杂志,2024,40(7):545-560.
|
[12] |
Papamargaritis D,Le Roux CW.Do gut hormones contribute to weight loss and glycaemic outcomes after bariatric surgery?[J].Nutrients,2021,13(3):1-26.
|
[13] |
Cegla J,Troke RC,Jones B,et al.Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intake [J].Diabetes,2014,63(11):3711-3720.
|
[14] |
Salem V,Izzi-Engbeaya C,Coello C,et al.Glucagon increases energy expenditure independently of brown adipose tissue activation in humans [J].Diabetes Obes Metab,2016,18(1):72-81.
|
[15] |
Tan TM,Field BCT,McCullough KA,et al.Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyper-glycemia [J].Diabetes,2013,62(4):1131-1138.
|
[16] |
le Roux CW,Steen O,Lucas KJ,et al.Glucagon and GLP-1 receptor dual agonist survodutide for obesity:a randomised,double-blind,placebo-controlled,dose-finding phase 2 trial [J].Lancet Diabetes Endocrinol,2024,12(3):162-173.
|
[17] |
Blüher M,Rosenstock J,Hoefler J,et al.Dose-response effects on HbA1c and bodyweight reduction of survodutide,a dual glucagon/GLP-1 receptor agonist,compared with placebo and open-label semaglutide in people with type 2 diabetes:a randomised clinical trial[J].Diabetologia,2024,67(3):470-482.
|
[18] |
Ji LN,Jiang HW,Cheng ZF,et al.A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity[J].Nat Commun,2023,14(1):8289.
|
[19] |
Innovent.玛仕度肽(IBI362)高剂量9 mg在中国肥胖受试者中的II期临床研究达到24周主要终点 [EB/OL].苏州:Innovent,2023.https://cn.innoventbio.com/#/news/485
|
[20] |
Klein S,Nestor JJ,Harris MS,et al.Pemvidutide (ALT-801),a Balanced (1:1) GLP-1/Glucagon dual receptor agonist,induces rapid and marked weight loss without the need for dose titration in people with overweight/obesity[J].Diabetes,2022,71:334-OR.
|
[21] |
Melson E,Ashraf U,Papamargaritis D,et al.What is the pipeline for future medications for obesity? [J].Int J Obes (Lond),2024,Online ahead of print.
|
[22] |
Alba M,Yee J,Frustaci ME,et al.Efficacy and safety of glucagonlike peptide-1/glucagon receptor co-agonist JNJ-64565111 in individuals with obesity without type 2 diabetes mellitus:a randomized doseranging study [J].Clin Obes,2021,11(2):e12432.
|
[23] |
Lu SC,Chen M,Atangan L,et al.GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys [J].Cell Rep Med,2021,2(5):100263.
|
[24] |
Murielle M.Veniant,Shu-Chen Lu,Larissa Atangan,et al.A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings [J].Nat Merab,2024,6(2):290-303.
|
[25] |
Coskun T,Urva S,Roell WC,et al.LY3437943,a novel triple glucagon,GIP,and GLP-1 receptor agonist for glycemic control and weight loss:from discovery to clinical proof of concept [J].Cell Metab.2022,34(9):1234-1247.
|
[26] |
Jastreboff AM,Kaplan LM,Frías JP,et al.Triple-hormone-receptor agonist retatrutide for obesity — A phase 2 trial [J].N Engl J Med,2023,389(6):514-526.
|
[27] |
Rosenstock J,Frias J,Jastreboff AM,et al.Retatrutide,a GIP,GLP-1 and glucagon receptor agonist,for people with type 2 diabetes:a randomised,double-blind,placebo and active-controlled,parallelgroup,phase 2 trial conducted in the USA [J].Lancet,2023,402(10401):529-544.
|
[28] |
Knop FK,Aroda VR,do Vale RD,et al.OASIS 1 Investigators,Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1):a randomised,double-blind,placebo-controlled,phase 3 trial [J].Lancet,2023,402(10403):705-719.
|
[29] |
Aroda VR,Aberle J,Bardtrum L,et al.Efficacy and safety of oncedaily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS):a multicentre,randomised,phase 3b trial [J].Lancet,2023,402(10403):693-704.
|
[30] |
Wilding J,Batterham RL,Calanna S,et al.Once-weekly semaglutide in adults with overweight or obesity [J].N Engl J Med,2021,384(11):989-1002.
|
[31] |
Davies M,Faerch L,J eppesen OK,et al.Semaglutide 2.4 mg once a week in adults with overweight or obesity,and type 2 diabetes(STEP2):a randomised,double-blind,double-dummy,placebocontrolled,phase 3 trial [J].Lancet,2021,397(10278):971-984.
|
[32] |
Frias JP,Hsia S,Eyde S,et al.Efficacy and safety of oral orforglipron in patients with type 2 diabetes:a multicentre,randomised,doseresponse,phase 2 study [J].Lancet,2023,402(10400):472-483.
|
[33] |
Wharton S,Blevins T,Connery L,et al.Daily oral GLP-1 receptor agonist orforglipron for adults with obesity [J].N Engl J Med,2023,389(10):877-888.
|
[34] |
Griffith DA,Edmonds DJ,Fortin JP,et al.A small-molecule oral agonist of the human glucagon-like peptide-1 receptor [J].J Med Chem,2022,65(12):8208-8226.
|
[35] |
Saxena AR,Frias JP,Brown LS,et al.Efficacy and safety of oral small molecule glucagon-like peptide 1 receptor agonist danuglipron for glycemic control among patients with type 2 diabetes:a randomized clinical trial [J].JAMA Netw Open,2023,6(5):e2314493.
|
[36] |
Lucacchini A.Amylin,Another important neuroendocrine hormone for the treatment of diabesity [J].Int J Mol Sci,2024,25(3):1517.
|
[37] |
Dehestani B,Stratford NRS,le Roux CW.Amylin as a future obesity treatment [J].J Obes Metab Syndr,2021,30(4):320-325.
|
[38] |
Frias JP,Deenadayalan S,Erichsen L,et al.Efficacy and safety of co-administered once-weekly cagrilintide 2.4 mg with once-weekly semaglutide 2.4 mg in type 2 diabetes:a multicentre,randomised,double-blind,active-controlled,phase 2 trial [J].Lancet,2023,402(10403):720-730.
|
[39] |
Sanyal AJ,Bedossa P,Fraessdorf M,et al.A phase 2 randomized trial of survodutide in MASH and fibrosis [J].N Engl J Med,2024,391(4):311-319.
|
[40] |
Romero-Gómez M,Lawitz E,Shankar RR,et al.A phase IIa activecomparator-controlled study to evaluate the efficacy and safety of efinopegdutide in patients with non-alcoholic fatty liver disease [J].J Hepatol,2023,79(4):888-897.
|
[41] |
Innovent.信达生物玛仕度肽在减重临床III期临床研究GLORY-1中肝脏脂肪含量降幅高达80.2% [EB/OL].苏州:Innovent,2024.https://cn.innoventbio.com/#/news/564
|
[42] |
Arun JS,Lee MK,Juan PF,et al.Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease:a randomized phase 2a trial [J].Nat Med,2024,30(7):2037-2048.
|
[43] |
Garito T,Roubenoff R,Hompesch M,et al.Bimagrumab improves body composition and insulin sensitivity in insulin-resistant individuals [J].Diabetes Obes Metab,2018,20(1):94-102.
|
[44] |
Heymsfield SB,Coleman LA,Miller R,et al.Effect of bimagrumab vs.placebo on body fat mass among adults with type 2 diabetes and obesity:A phase 2 randomized clinical trial [J].JAMA Netw Open,2021,4(1):e2033457.
|
[45] |
Rooks D,Swan T,Goswami B,et al.Bimagrumab vs Optimized standard of care for treatment of sarcopenia in community-dwelling older adults:A randomized clinical trial [J].JAMA Netw Open,2020,3(10):e2020836.
|
[46] |
Rubino D,Abrahamsson N,Davies M,et al.Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance in adults with overweight or obesity:The STEP 4 randomized clinical trial [J].JAMA,2021,325(14):1414-1425.
|
[47] |
Aronne LJ,Sattar N,Horn DB,et al.surmount-4 investigators,continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity:The SURMOUNT-4 randomized clinical trial [J].JAMA,2024,331(1):38-48.
|
[48] |
Lingvay I,Agarwal S.A revolution in obesity treatment [J].Nat Med,2023,29(10):2406-2408.
|
[49] |
Zhang L,Chen J,Zhang J,et al.Regional disparities in obesity among a heterogeneous population of Chinese children and adolescents [J].JAMA Netw Open,2021,4(10):e2131040.
|
[50] |
Joe Eun Son.Genetics,pharmacotherapy,and dietary interventions in childhood obesity [J].J Pharm Pharm Sci,2024,27:12861.
|
[51] |
Lingvay I,Sumithran P,le Roux CW,et al.There is no magic bullet for obesity [J].Lancet Diabetes Endocrinol,2023,11(8):541.
|
[52] |
Verges B.Do anti-obesity medical treatment have a direct effect on adipose tissue? [J].Ann Endocrinol (Paris),2024,85(3):179-183.
|
[53] |
Miras AD,Pérez-Pevida B,Aldhwayan M,et al.Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS):a randomised,double-blind,placebo-controlled trial [J].Lancet Diabetes Endocrinol,2019,7(7):549-559.
|