The prevalence of gout in China is increasing year by year, and it shows a trend of youthfulness. Uric acid can not only be deposited in common joints, causing classic gout attacks, but also widely deposited in various parts of the body, showing atypical pathogenic manifestations. Many reasons, such as atypical clinical manifestations, special location, special population, lack of clinical understanding, and cover-up of comorbidity, have greatly increased the difficulty of clinical diagnosis and treatment, and the probability of clinical missed diagnosis and misdiagnosis is high, which deserves the attention of clinicians. Traditional imaging examination has limited diagnostic value. Dual-energy computed tomography (DECT) can specifically identify urate crystals, which is helpful for diagnosis. Through literature review, this paper summarizes the atypical clinical manifestations of uric acid deposition, and provides reference for clinical diagnosis and treatment.