Sleeve gastrectomy (SG), currently the most widely performed metabolic and bariatric surgery, demonstrates high safety and efficacy. However, the significant postoperative weight regain rate adversely affects patient prognosis. At present, the primary intervention for weight recurrence after SG is surgical revision, including procedures such as re-SG and Roux-en-Y gastric bypass (RYGB). Nevertheless, these surgical approaches are associated with considerable trauma, a higher incidence of complications, and the potential for recurrent weight regain. In contrast, minimally invasive non-surgical interventions offer distinct advantages in managing post-SG weight regain. Current non-surgical strategies include lifestyle modification, psychological intervention, pharmacotherapy, and endoscopic treatments. These methods exert their effects through multiple mechanisms, such as modulating metabolic adaptation, altering lifestyle behaviors, improving endocrine function, and maintaining gastric volume. Collectively, they provide safer and more effective options for postoperative weight management following SG.