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Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition) ›› 2025, Vol. 11 ›› Issue (01): 33-39. doi: 10.3877/cma.j.issn.2095-9605.2025.01.005

• Expert Forum • Previous Articles    

Clinical research status and progress of novel anti-obesity medications targeting nutrient-stimulatory hormone receptors

Yujia Song1, Hua Meng2,()   

  1. 1. Capital Medical University,Beijing,100069,China
    2. Obesity and Metabolic Disease Center,Department of General Surgery,China-Japan Friendship Hospital,Beijing,100029,China
  • Received:2024-11-20 Online:2025-02-28 Published:2025-04-22
  • Contact: Hua Meng

Abstract:

The global prevalence of obesity has escalated at an alarming rate,with China facing an increasingly critical obesity crisis.Recognized as a chronic,relapsing,and multifaceted disease,obesity significantly compromises both the health span and quality of life of those affected.New anti-obesity agents that target the nutrient-stimulated hormone (NuSH) receptor offer a promising alternative to bariatric surgery,serving as a vital adjunct to lifestyle interventions.Clinical trials have demonstrated that these novel therapies not only achieve substantial weight reduction but also improve outcomes in type 2 diabetes,cardiovascular disease,and other obesity-related comorbidities,with their safety profiles well-established.To date,four new weight-loss medications have received approval for weight management in China,and several others are advancing through Phase Ⅲ clinical trials.Nonetheless,there remain challenges to be addressed in the clinical evaluation and application of these therapies.Looking ahead,as these challenges are progressively overcome,the potential for enhanced weight-loss outcomes,more personalized treatment options,and diverse therapeutic applications will enable these novel weight-loss drugs to play an increasingly significant role in the management of obesity.

Key words: Anti-obesity agents, Nutrient-stimulatory hormone, Obesity, Type 2 diabetes mellitus, Cardiovascular disease, Glucagon-like peptide-1

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