Abstract:

Objective

To identify the factors that best predict the risk of atherosclerosis in male patients with type 2 diabetes mellitus（T2DM） from the parameters evaluated by the oral glucose tolerance test （OGTT）.

Methods

A total of 171 hospitalized male patients with T2DM in Tianjin Medical University Chu Hsien-I Memorial Hospital from October 2019 to October 2023 were divided into atherogenic phenotype group （group A， AIP≥0.06） and non-atherogenic phenotype group （group N， AIP＜0.06）.The patients were accepted OGTT.The homeostasis model insulin resistance index （HOMA-IR）， insulin secretion index（HOMA-β）， insulin action index （IAI）， quantitative insulin sensitivity check index （QUICKI）， C peptide insulin resistance index （HOMA IR-CP） and C-peptide islet function index suitable for diabetes patients（HOMA islet-CP DM） were calculated according to OGTT results.

Results

Fasting C-peptide， C-peptide values at 60 min and 120min after oral administration of 75g glucose， ln（HOMA-IR）， ln （HOMA-β）， ln（HOMA IR-CP） and ln （HOMA islet-CP DM） in Group A were higher than those in group N （P＜0.05），while IAI and QUICKI were lower than those in group N （P＜0.05）.AIP was positively correlated with C-peptide values at different times， ln（HOMA-IR）， ln （HOMA-β）， Ln（HOMA-IR-CP） and ln（HOMA islet CP-DM） （P＜0.001）， while negatively correlated with IAI and QUICKI （P＜0.001）.Multiple linear regression analysis showed that fasting C-peptide and QUICKI were independent influencing factors of AIP.

Conclusions

Fasting C-peptide and QUICKI are independent predictors of AIP in male patients with type 2 diabetes， which deserves clinicians' attention.

Key words: C peptide, Quantitative insulin sensitivity check index, Atherosclerosis, Male, Type 2 diabetes mellitus, Oral glucose tolerance test