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Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition) ›› 2025, Vol. 11 ›› Issue (02): 148-152. doi: 10.3877/cma.j.issn.2095-9605.2025.02.010

• Review • Previous Articles    

Research progress of bone morphogenetic proteins regulation on brown fat cells

Xiaoyan Gou1, Xiaoping Fan1, Ran Zou1, Yalian Sa2, Yong Li1,()   

  1. 1Department of Radiology, Suining Central Hospital of Sichuan Province, Suinin 629099, China
    2Clinical Research Center, The First People's Hospital of Yunnan Province, Kunming 650034, China
  • Received:2024-09-12 Online:2025-05-30 Published:2025-09-06
  • Contact: Yong Li

Abstract:

Bone morphogenetic proteins (BMPs) are members of the TGF-β family, which regulate key processes such as embryonic development and differentiation. The SMAD1/5/8 pathway is activated by type I receptors (activin receptor-like Kinase ALK 1, 2, 3 or 6) and type II receptors (2A or 2B). Brown adipose tissue is a unique thermogenic tissue that has emerged as a focal point in addressing obesity, diabetes, and other metabolic diseases in recent years. BMP2, 4, 6, 7, 8b, 14, and MB109 have been demonstrated to play an increasingly significant role in the development of brown adipose tissue and the metabolic regulation of mature adipocytes. This article summarizes the regulatory role of BMPs in brown adipose-related signaling pathways and their potential application in the treatment of metabolic diseases, thereby providing a reference for the clinical treatment of metabolic diseases with brown adipose-targeted approaches.

Key words: Brown fat, Bone morphogenetic proteins, uncoupling protein 1, Metabolic diseases

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