Research progress of brain-enteric-bacterial axis mechanism in weight-loss metabolic surgery

doi:10.3877/cma.j.issn.2095-9605.2023.01.009

Abstract

Abstract:

Obesity is a global epidemic with enormous social and economic burdens. Bariatric metabolic surgery (BMS) is the most effective treatment for obesity, and its mechanism has been explored. More and more clinical studies have confirmed that the brain-enteric-bacterial axis plays an important role in the pathophysiological mechanism of obesity, but there is a lack of review in this field. In this paper, the brain-entero-bacterial axis mechanism of changes in the nervous system, metabolism, endocrine system, immune system and microbial group in patients with obesity after BMS was reviewed, in order to clarify the mechanism of BMS treatment for obesity and provide relevant basis and reference for postoperative weight management in patients with obesity.

Key words: Bariatric metabolic surgery, Obesity, Brain-enteric-bacterial axis, Summary, Metabolic change, Weight management

Yongbing Sun, Jing Zhou, Dongpeng Wen, Junya He, Xinbei Lin, Qi Qiao, Zhonglin Li, Cheng Zhang, Zhikai Wang, Jiancheng Zhang, Xiaoling Wu, Zhi Zou, Yong Wang, Yongli Li. Research progress of brain-enteric-bacterial axis mechanism in weight-loss metabolic surgery[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2023, 09(01): 43-49.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhfpydxbdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-9605.2023.01.009

https://zhfpydxbdzzz.cma-cmc.com.cn/EN/Y2023/V09/I01/43

Figures/Tables 2

References 57

[1]	Wang Y, Zhao L, Gao L, et al. Health policy and public health implications of obesity in China [J]. Lancet Diabetes Endocrinol, 2021, 9(7): 446-461.
[2]	Gadelha Bezerra Silva B, Veras Oliveira A, Almeida de Sousa Jucá M, et al. Management of gastric ectopic pancreas identified in preoperative evaluation of bariatric surgery - A case report [J]. Int J Surg Case Rep, 2020, 77: 353-356.
[3]	Sjöström L, Narbro K, Sjöström CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects [J]. N Engl J Med, 2007, 357(8): 741-752.
[4]	Martin C R, Osadchiy V, Kalani A, et al. The Brain-Gut-Microbiome Axis [J]. Cell Mol Gastroenterol Hepatol, 2018, 6(2): 133-148.
[5]	Gupta A, Osadchiy V, Mayer E A. Brain-gut-microbiome interactions in obesity and food addiction [J]. Nat Rev Gastroenterol Hepatol, 2020, 17(11): 655-672.
[6]	曾钊, 刘娟. 中共中央国务院印发《"健康中国2030"规划纲要》 [J]. 中华人民共和国国务院公报, 2016, 32: 5-20.
[7]	Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 [J]. Nature, 2009, 461(7268): 1282-1286.
[8]	Nuzzo A, Czernichow S, Hertig A, et al. Prevention and treatment of nutritional complications after bariatric surgery [J]. Lancet Gastroenterol Hepatol, 2021, 6(3): 238-251.
[9]	Garruti G, De Fazio M, Capuano P, et al. Exercise and apulian hypocaloric diet affect adipokine changes and gastric banding-induced weight loss: A prospective study on severe obese subjects [J]. Ann Med Surg (Lond), 2020, 52:10-5.
[10]	Zafar A, Khatri IA. An overview of complications affecting the Central Nervous System following bariatric surgery [J]. Neurosciences (Riyadh), 2018, 23(1): 4-12.
[11]	Ochner C N, Gibson C, Shanik M, et al. Changes in neurohormonal gut peptides following bariatric surgery [J]. Int J Obes (Lond), 2011, 35(2): 153-166.
[12]	Guo Y, Huang ZP, Liu CQ, et al. Modulation of the gut microbiome: a systematic review of the effect of bariatric surgery [J]. Eur J Endocrinol, 2018, 178(1): 43-56.
[13]	Li G, Ji G, Hu Y, et al. Reduced plasma ghrelin concentrations are associated with decreased brain reactivity to food cues after laparoscopic sleeve gastrectomy [J]. Psychoneuroendocrinology, 2019, 100: 229-236.
[14]	Frank S, Wilms B, Veit R, et al. Altered brain activity in severely obese women may recover after Roux-en Y gastric bypass surgery [J]. Int J Obes (Lond), 2014, 38(3): 341-348.
[15]	Angelidi AM, Belanger MJ, Kokkinos A, et al. Novel Noninvasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy [J]. Endocr Rev, 2022, 43(3): 507-557.
[16]	Battineni G, Sagaro GG, Chintalapudi N, et al. Impact of Obesity-Induced Inflammation on Cardiovascular Diseases (CVD) [J]. Int J Mol Sci, 2021, 22(9):4798.
[17]	De Lima-Júnior JC, Velloso LA, Geloneze B. The Obese Brain--Effects of Bariatric Surgery on Energy Balance Neurocircuitry [J]. Curr Atheroscler Rep, 2015, 17(10): 57.
[18]	van de Sande-Lee S, Pereira FR, Cintra DE, et al. Partial reversibility of hypothalamic dysfunction and changes in brain activity after body mass reduction in obese subjects [J]. Diabetes, 2011, 60(6): 1699-1704.
[19]	Zeighami Y, Iceta S, Dadar M, et al. Spontaneous neural activity changes after bariatric surgery: A resting-state fMRI study [J]. Neuroimage, 2021, 241: 118419-118429.
[20]	Berthoud HR, Shin A C, Zheng H. Obesity surgery and gut-brain communication [J]. Physiol Behav, 2011, 105(1): 106-119.
[21]	Stefanidis A, Oldfield BJ. Neuroendocrine mechanisms underlying bariatric surgery: Insights from human studies and animal models [J]. J Neuroendocrinol, 2017, 29(10): 10.
[22]	Ionut V, Burch M, Youdim A, et al. Gastrointestinal hormones and bariatric surgery-induced weight loss [J]. Obesity (Silver Spring), 2013, 21(6): 1093-1103.
[23]	Almeida P P, Valdetaro L, Thomasi B B M, et al. High-fat diets on the enteric nervous system: Possible interactions and mechanisms underlying dysmotility [J]. Obes Rev, 2022, 23(4): e13404.
[24]	Bravo J A, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve [J]. Proc Natl Acad Sci USA, 2011, 108(38): 16050-16055.
[25]	Bercik P, Denou E, Collins J, et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice [J]. Gastroenterology, 2011, 141(2): 599-609, e1-3.
[26]	Fried S, Wemelle E, Cani PD, et al. Interactions between the microbiota and enteric nervous system during gut-brain disorders [J]. Neuropharmacology, 2021, 197: 108721.
[27]	刘金钢. 减重手术术式选择及对机体代谢的调节 [J]. 肠外与肠内营养, 2020, 27(1): 1-4.
[28]	Yu H, Li Q, Zhang M, et al. Decreased Leptin Is Associated with Alterations in Thyroid-Stimulating Hormone Levels after Roux-en-Y Gastric Bypass Surgery in Obese Euthyroid Patients with Type 2 Diabetes [J]. Obes Facts, 2019, 12(3): 272-280.
[29]	Hu J, Wang M, Zhou Y, et al. Bariatric Surgery in Rats Upregulates FSP27 Expression in Fat Tissue to Affect Fat Hydrolysis and Metabolism [J]. Biomed Res Int, 2019, 2019(8):1-11.
[30]	Dadson P, Hannukainen JC, Din MU, et al. Brown adipose tissue lipid metabolism in morbid obesity: Effect of bariatric surgery-induced weight loss [J]. Diabetes Obes Metab, 2018, 20(5): 1280-1288.
[31]	Chen Y, Yang J, Nie X, et al. Effects of Bariatric Surgery on Change of Brown Adipocyte Tissue and Energy Metabolism in Obese Mice [J]. Obes Surg, 2018, 28(3): 820-830.
[32]	刘娟, 郑喜兰. 肥胖病人减重代谢手术后微量营养素缺乏症的研究进展 [J]. 全科护理, 2022, 20(03): 345-350.
[33]	Bauer PV, Hamr SC, Duca FA. Regulation of energy balance by a gut-brain axis and involvement of the gut microbiota [J]. Cell Mol Life Sci, 2016, 73(4): 737-755.
[34]	Namgung U, Kim KJ, Jo BG, et al. Vagus nerve stimulation modulates hippocampal inflammation caused by continuous stress in rats [J]. J Neuroinflammation, 2022, 19(1): 33.
[35]	Hatoum IJ, Stylopoulos N, Vanhoose AM, et al. Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery [J]. J Clin Endocrinol Metab, 2012, 97(6): E1023-1031.
[36]	Mumphrey MB, Patterson LM, Zheng H, et al. Roux-en-Y gastric bypass surgery increases number but not density of CCK-, GLP-1-, 5-HT-, and neurotensin-expressing enteroendocrine cells in rats [J]. Neurogastroenterol Motil, 2013, 25(1): e70-79.
[37]	Valenzano A, Tartaglia N, Ambrosi A, et al. The Metabolic Rearrangements of Bariatric Surgery: Focus on Orexin-A and the Adiponectin System [J]. J Clin Med, 2020, 9(10):3327-3337.
[38]	Gupta A, Miegueu P, Lapointe M, et al. Acute post-bariatric surgery increase in orexin levels associates with preferential lipid profile improvement [J]. PLoS One, 2014, 9(1): e84803.
[39]	Cigdem Arica P, Kocael A, Tabak O, et al. Plasma ghrelin, leptin, and orexin-A levels and insulin resistance after laparoscopic gastric band applications in morbidly obese patients [J]. Minerva Med, 2013, 104(3): 309-316.
[40]	Egeberg A, Sørensen JA, Gislason GH, et al. Incidence and Prognosis of Psoriasis and Psoriatic Arthritis in Patients Undergoing Bariatric Surgery [J]. JAMA Surg, 2017, 152(4): 344-349.
[41]	Frasca D, Diaz A, Romero M, et al. Secretion of autoimmune antibodies in the human subcutaneous adipose tissue [J]. PLoS One, 2018, 13(5): e0197472.
[42]	Cuellar-Tamez RX, Villarreal-Calderon J R, Rubio-Infante N, et al. Bariatric surgery-induced weight loss reduces B cell activating cytokines and IgG immunoglobulins related to autoimmunity [J]. Surg Endosc, 2021, 35(9): 5147-5158.
[43]	李淑婷, 尹星琪, 赵冬, 等. 减重代谢手术的减重机制研究进展 [J]. 中国临床医生杂志, 2021, 49(3): 273-275.
[44]	Chen J, Haase N, Haange SB, et al. Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk [J]. Mol Metab, 2021, 48: 101214.
[45]	Guo Y, Liu CQ, Liu GP, et al. Roux-en-Y gastric bypass decreases endotoxemia and inflammatory stress in association with improvements in gut permeability in obese diabetic rats [J]. J Diabetes, 2019, 11(10): 786-793.
[46]	Chen H, Qian L, Lv Q, et al. Change in gut microbiota is correlated with alterations in the surface molecule expression of monocytes after Roux-en-Y gastric bypass surgery in obese type 2 diabetic patients [J]. Am J Transl Res, 2017, 9(3): 1243-1254.
[47]	Sanchez M, Darimont C, Panahi S, et al. Effects of a Diet-Based Weight-Reducing Program with Probiotic Supplementation on Satiety Efficiency, Eating Behaviour Traits, and Psychosocial Behaviours in Obese Individuals [J]. Nutrients, 2017, 9(3): 284-300.
[48]	Roth W, Zadeh K, Vekariya R, et al. Tryptophan Metabolism and Gut-Brain Homeostasis [J]. Int J Mol Sci, 2021, 22(6): 2973-2994.
[49]	Kessler RM, Hutson PH, Herman BK, et al. The neurobiological basis of binge-eating disorder [J]. Neurosci Biobehav Rev, 2016, 63: 223-238.
[50]	Dalmas E, Rouault C, Abdennour M, et al. Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction [J]. Am J Clin Nutr, 2011, 94(2): 450-458.
[51]	Palleja A, Kashani A, Allin KH, et al. Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota [J]. Genome Med, 2016, 8(1): 67-69.
[52]	Frost G, Sleeth ML, Sahuri-Arisoylu M, et al. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism [J]. Nat Commun, 2014, 5(1): 3611-3621.
[53]	Dong TS, Mayer EA, Osadchiy V, et al. A Distinct Brain-Gut-Microbiome Profile Exists for Females with Obesity and Food Addiction [J]. Obesity (Silver Spring), 2020, 28(8): 1477-1486.
[54]	Hong J, Bo T, Xi L, et al. Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity [J]. J Clin Endocrinol Metab, 2021, 106(9): e3619-e3633.
[55]	Jennis M, Cavanaugh CR, Leo GC, et al. Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo [J]. Neurogastroenterol Motil, 2018, 30(2): 13178.
[56]	Yano JM, Yu K, Donaldson GP, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis [J]. Cell, 2015, 161(2): 264-276.
[57]	Altieri MS, Irish W, Pories WJ, et al. Examining the Rates of Obesity and Bariatric Surgery in the United States [J]. Obes Surg, 2021, 31(11): 4754-4760.

Please choose a citation manager

Content to export