The role of exosomalmiRNA in the occurrence and development of obesity and obesity-related disease

doi:10.3877/cma.j.issn.2095-9605.2022.02.009

Abstract

Abstract:

Exosomes are a type of extracellular vesicles (EVs) with phospholipid bilayer membrane structure and contain a variety of biologically active substances. Exosomes may play a role in obesity by regulating adipose tissue function, formation, and transformation. The miRNA profile of exosomes changes in obesity, which can regulate obesity-related insulin resistance, liver and pancreas function. In addition, adipose-derived stem cells (ADSC-Exos) regulate the phenotype of ATMs to improve obesity-related inflammation. This paper reviews the role of exosomes in the occurrence and development of obesity and obesity-related disease.

Key words: Obesity, Exosomes, miRNA, Adipose tissue

Aili Aikebaier·, Tusuntuoheti Yusujiang·, Maimaitiming Maimaiti aili·, Jianyu Cui, Xin Li, Abudureyimu Kelimu·. The role of exosomalmiRNA in the occurrence and development of obesity and obesity-related disease[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(02): 123-129.

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