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中华肥胖与代谢病电子杂志 ›› 2024, Vol. 10 ›› Issue (02) : 108 -112. doi: 10.3877/cma.j.issn.2095-9605.2024.02.006

青年专家论坛

肥胖与中枢神经系统调控的研究进展
王婉杰1, 宋文超1, 王键1, 倪良晨1, 洪健1, 朱孝成1, 姚立彬1,()   
  1. 1. 221006 江苏省徐州市,徐州医科大学附属医院减重代谢外科
  • 收稿日期:2024-03-10 出版日期:2024-05-30
  • 通信作者: 姚立彬

Research progress on obesity and central nervous system regulation

Wanjie Wang1, Wenchao Song1, Jian Wang1, Liangchen Ni1, Jian Hong1, Xiaocheng Zhu1, Libin Yao1,()   

  1. 1. Department of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, China
  • Received:2024-03-10 Published:2024-05-30
  • Corresponding author: Libin Yao
引用本文:

王婉杰, 宋文超, 王键, 倪良晨, 洪健, 朱孝成, 姚立彬. 肥胖与中枢神经系统调控的研究进展[J]. 中华肥胖与代谢病电子杂志, 2024, 10(02): 108-112.

Wanjie Wang, Wenchao Song, Jian Wang, Liangchen Ni, Jian Hong, Xiaocheng Zhu, Libin Yao. Research progress on obesity and central nervous system regulation[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(02): 108-112.

肥胖是长期能量失衡导致的病理状态,已成为全球公共卫生的重大问题。中枢神经系统在维持能量平衡中发挥重要作用,它通过调节食物摄入和能量消耗来直接影响体重。近年来,脑-肠轴机制在肥胖研究中的重要性日益显著,肠道肽与下丘脑中的受体结合,影响中枢神经系统的功能。本文综述了中枢神经系统中的稳态系统和享乐系统对摄食的调节,探讨了下丘脑在调节能量消耗中的作用。同时阐述了脑-肠轴中肠道肽和肠道微生物对中枢神经系统调节摄食的影响以及减重术后脑肠轴的改变,为肥胖的预防和治疗提供了新的研究思路。

Obesity is a pathological state caused by long-term energy imbalance and has become a major global public health issue. The central nervous system (CNS) plays a crucial role in maintaining energy balance, directly influencing body weight by regulating food intake and energy expenditure. In recent years, the significance of the brain-gut axis in obesity research has become increasingly prominent. Gut peptides interact with receptors in the brain, affecting CNS function. This article reviews the homeostatic and hedonic systems in the CNS that regulate eating, discusses the role of the hypothalamus in regulating energy expenditure, and describes how gut peptides and microbiota in the brain-gut axis influence CNS regulation of food intake and the changes in the brain-gut axis after weight loss surgery, offering new research perspectives for the prevention and treatment of obesity.

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