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中华肥胖与代谢病电子杂志 ›› 2024, Vol. 10 ›› Issue (04) : 255 -260. doi: 10.3877/cma.j.issn.2095-9605.2024.04.005

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肥胖与抑郁症相关性的研究进展
张鑫1, 刘志芬2, 郭云童3,()   
  1. 1.030001 太原,山西医科大学第一临床医学院
    2.山西医学大学第一医院精神卫生
    3.山西医学大学第一医院胃肠外科
  • 收稿日期:2024-03-22 出版日期:2024-11-30
  • 通信作者: 郭云童

Research progress on the correlation between obesity and depression

Xin Zhang1,2, Zhifen Liu3, Yuntong Guo4,()   

  1. 1.The First Clinical College of Medicine, Shanxi Medical University, Taiyuan 030001,
    2.China
    3.Department of Mental Health, Taiyuan 030001,China
    4.Department of gastrointestinal surgery, the First Hospital of Shanxi Medical University, Taiyuan 030001,China
  • Received:2024-03-22 Published:2024-11-30
  • Corresponding author: Yuntong Guo
引用本文:

张鑫, 刘志芬, 郭云童. 肥胖与抑郁症相关性的研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(04): 255-260.

Xin Zhang, Zhifen Liu, Yuntong Guo. Research progress on the correlation between obesity and depression[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(04): 255-260.

肥胖和抑郁是两种常见的健康问题,二者之间存在着共同的发病机制,相互关联,即肥胖可以增加抑郁的发病风险,反过来,抑郁也会增加患肥胖的风险。其中,激素水平、神经递质的改变、炎症反应、遗传等因素被认为是两者之间关系的重要介导因素。此外,环境因素如饮食习惯、运动行为以及社会心理因素如自尊、社会支持等也对肥胖与抑郁之间的关系产生影响。本文就肥胖与抑郁之间的病因及关联机制进行全面总结及综述,倡导科学有效减重,旨在为这类患者的早期预防和临床治疗提供更多可靠依据。

Obesity and depression are two common health problems, and there are common pathogenesis and correlation between them.That is, obesity can increase the risk of depression, which in turn can increase the risk of developing obesity.Among them, hormone levels, neurotransmitter changes,inflammatory response, inheritance, and other factors are important mediators of the relationship between the two.In addition, environmental factors such as eating habits and exercise behavior, and psychosocial factors such as self-esteem and social support also have an impact on the relationship between obesity and depression.In this paper, the etiology and related mechanisms between obesity and depression are comprehensively summarized and summarized, and scientific and effective weight loss is advocated, aiming to provide more reliable evidence for early prevention and clinical treatment of these patients.

[1]
GBD 2016 DALYs and HALE Collaborators.Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 [J].Lancet, 2017, 390(10100): 1260-1344.
[2]
Milano W, Ambrosio P, Carizzone F, et al.depression and obesity:analysis of common biomarkers [J].Diseases, 2020, 8(2): 23.
[3]
Rosas LG, Xiao L, Lv N, et al.Understanding mechanisms of integrated behavioral therapy for co-occurring obesity and depression in primary care: a mediation analysis in the RAINBOW trial [J].Transl Behav Med, 2021, 11(2): 382-392.
[4]
Lores T, Musker M, Collins K, et al.Pilot trial of a group cognitive behavioural therapy program for comorbid depression and obesity [J].BMC Psychol, 2020, 8(1): 34.
[5]
Borgland SL.Can treatment of obesity reduce depression or vice versa? [J].J Psychiatry Neurosci, 2021, 46(2): E313-E318.
[6]
Murton LM, Plank LD, Cutfield R, et al.Bariatric Surgery and psychological health: a randomised clinical trial in patients with obesity and type 2 diabetes [J].Obes Surg, 2023, 33(5): 1536-1544.
[7]
Moreira FP, Jansen K, Cardoso TA, et al.Metabolic syndrome,depression and anhedonia among young adults [J].Psychiatry Res,2019, 271: 306-310.
[8]
LIhua M, Tao Z, Hongbin M, et al.Metabolic syndrome risk in relation to posttraumatic stress disorder among trauma-exposed civilians in Gansu Province, China [J].Medicine (Baltimore), 2020,99(1): e18614.
[9]
Villarreal-Zegarra D, Bernabe-Ortiz A.Association between arterial hypertension and depressive symptoms: Results from populationbased surveys in Peru [J].Asia Pac Psychiatry, 2020, 12(2): e12385.
[10]
Rotter I, Wiatrak A, Rył A, et al.The relationship between the concentration of magnesium and the presence of depressive symptoms and selected metabolic disorders among men over 50 years of age [J].Life (Basel), 2021, 11(3): 196.
[11]
Xu L, Wang K, Wang S, et al.Sex differences in the association between serum lipids and depressive symptoms: A longitudinal population-based study [J].J Affect Disord, 2021, 291: 154-162.
[12]
Hitij JB.Association of depressive symptoms and hypertension prevalence, awareness, treatment [J].J Hypertens, 2022, 40(9): 1655-1657.
[13]
Qiu W, Cai X, Zheng C, et al.Update on the Relationship Between Depression and Neuroendocrine Metabolism [J].Front Neurosci,2021, 15: 728810.
[14]
Ji S, Chen Y, Zhou Y, et al.Association between anxiety and metabolic syndrome: An updated systematic review and meta-analysis [J].Front Psychiatry, 2023, 14: 1118836.
[15]
de Wit L, Luppino F, van Straten A, et al.Depression and obesity: a meta-analysis of community-based studies [J].Psychiatry Res, 2010,178(2): 230-235.
[16]
Plackett B.The vicious cycle of depression and obesity [J].Nature,2022, 608(7924): S42-S43.
[17]
Choy WC, López-León S, Aulchenko YS, et al.Role of shared genetic and environmental factors in symptoms of depression and body composition [J].Psychiatr Genet, 2009, 19(1): 32-38.
[18]
Habib S, Sangaraju SL, Yepez D, et al.The nexus between diabetes and depression: A Narrative Review [J].Cureus, 2022, 14(6): e25611.
[19]
Preiss K, Brennan L, Clarke D.A systematic review of variables associated with the relationship between obesity and depression [J].Obes Rev, 2013, 14(11): 906-918.
[20]
Syeda JN, Rutkofsky IH, Muhammad AS, et al.The psycho-cardiac coupling, myocardial remodeling, and neuroendocrine factor levels:The psychosomatics of major depressive disorder [J].Cureus, 2018,10(4): e2464.
[21]
Milano W, Ambrosio P, Carizzone F, et al.Depression and obesity:analysis of common biomarkers [J].Diseases, 2020, 8(2): 23.
[22]
Ye Z, Zhu L, Li XJ, et al.PC6 electroacupuncture reduces stressinduced autonomic and neuroendocrine responses in rats [J].Heliyon,2023, 9(4): e15291.
[23]
Vignjević PS, Milošević MS, Marković D, et al.Interplay between stress and cancer—A focus on inflammation [J].Front Physiol, 2023,14: 1119095.
[24]
Guo H, Zheng L, Xu H, et al.neurobiological links between stress,brain injury, and disease [J].Oxid Med Cell Longev, 2022, 2022:8111022.
[25]
Zeyen L, Seternes OM, Mikkola I.Crosstalk between p38 MAPK and GR Signaling [J].Int J Mol Sci, 2022, 23(6): 3322.
[26]
Soczynska JK, Kennedy SH, Woldeyohannes HO, et al.Mood disorders and obesity: understanding inflammation as a pathophysiological nexus [J].Neuromolecular Med, 2011, 13(2): 93-116.
[27]
Taylor VH, Macqueen GM.The role of adipokines in understanding the associations between obesity and depression [J].J Obes, 2010,2010: 748048.
[28]
Ugur M, Kanit L, Koylu EO, et al.Cocaine- and amphetamineregulated transcript promoter regulated by nicotine in nerve growth factor-treated PC12 cells [J].Physiol Int, 2019, 106(3): 272-282.
[29]
Scheen A.Obesity, type 2 diabetes, metabolic syndrome and depression: a two-way relationship [J].Rev Med Liege, 2023, 78(4):199-203.
[30]
Afari N, Noonan C, Goldberg J, et al.Depression and obesity: do shared genes explain the relationship? [J].Depress Anxiety, 2010,27(9): 799-806.
[31]
Jokela M, Elovainio M, Keltikangas-Järvinen L, et al.Body mass index and depressive symptoms: instrumental-variables regression with genetic risk score [J].Genes Brain Behav, 2012, 11(8): 942-948.
[32]
Han S, Cui Q, Wang X, et al.Resting state functional network switching rate is differently altered in bipolar disorder and major depressive disorder [J].Hum Brain Mapp, 2020, 41(12): 3295-3304.
[33]
Sahafnejad Z, Ramazi S, Allahverdi A.An Update of Epigenetic Drugs for the Treatment of Cancers and Brain Diseases: A Comprehensive Review [J].Genes (Basel), 2023, 14(4): 873.
[34]
Panariello F, Fanelli G, Fabbri C, et al.Epigenetic basis of psychiatric disorders: A narrative review [J].CNS Neurol Disord Drug Targets,2022, 21(4): 302-315.
[35]
Gharipour M, Barekatain M, Sung J, et al.the epigenetic overlap between obesity and mood disorders: A systematic review [J].Int J Mol Sci, 2020, 21(18): 6758.
[36]
Bray GA.Obesity: a 100 year perspective [J].Int J Obes (Lond),Published online May 7, 2024.
[37]
Nogrady B.Habit-linked brain circuits light up in people with eating disorders [J].Nature, Published online April 4, 2023.
[38]
van Dijk SJ, Molloy PL, Varinli H, et al.Epigenetics and human obesity [J].Int J Obes (Lond), 2015, 39(1): 85-97.
[39]
El Ghoch M, Calugi S, Dalle Grave R.The effects of lowcarbohydrate diets on psychosocial outcomes in obesity/overweight:a systematic review of randomized, controlled studies [J].Nutrients,2016, 8(7): 402-402.
[40]
Fabricatore AN, Wadden TA, Higginbotham AJ, et al.Intentional weight loss and changes in symptoms of depression: a systematic review and meta-analysis [J].Int J Obes (Lond), 2011, 35(11): 1363-1376.
[41]
Grilo CM, White MA.Orlistat with behavioral weight loss for obesity with versus without binge eating disorder: randomized placebo-controlled trial at a community mental health center serving educationally and economically disadvantaged Latino/as [J].Behav Res Ther, 2013, 51(3): 167-175.
[42]
Weghuber D, Barrett T, Barrientos-Pérez M, et al.Once-weekly semaglutide in adolescents with obesity [J].N Engl J Med, 2022,387(24): 2245-2257.
[43]
Ben Othman R, Ben Amor N, Mahjoub F, et al.A clinical trial about effects of prebiotic and probiotic supplementation on weight loss,psychological profile and metabolic parameters in obese subjects [J].Endocrinol Diabetes Metab, 2023, 6(2): e402.
[44]
CourcoulasAP, Gallagher JW, Neiberg RH, et al.Bariatric surgery vs lifestyle intervention for diabetes treatment: 5-year outcomes from a randomized trial [J].Journal Of Clinical Endocrinology &Metabolism, 2020, 105(3): 866-876.
[45]
Kotackova L, Marecek R, Mouraviev A, et al.Bariatric surgery and its impact on depressive symptoms, cognition, brain and inflammation[J].Front Endocrinol (Lausanne), 2023, 14: 1171244.
[46]
Aylward L, Lilly C, Konsor M, et al.How soon do depression and anxiety symptoms improve after bariatric surgery? [J].Healthcare(Basel), 2023, 11(6): 862-862.
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