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中华肥胖与代谢病电子杂志

中华肥胖与代谢病电子杂志 ›› 2018, Vol. 04 ›› Issue (04) : 218 -225. doi: 10.3877/cma.j.issn.2095-9605.2018.04.006

所属专题： 文献；

综述

代谢手术相关的组学研究方法及进展
沈奇伟1, 刘思颖1, 花荣1, 许博1, 邵怡凯1, 姚琪远1,†()   
  1. 1. 200040　上海，复旦大学附属华山医院普外科
  • 收稿日期:2018-09-10 出版日期:2018-11-30
  • 通信作者: 姚琪远
  • 基金资助:
    国家自然科学基金（青年项目）(81800751)

Methodology and progress of histology related to metabolic surgery

Qiwei Shen1, Siying Liu1, Rong Hua1   

  • Received:2018-09-10 Published:2018-11-30
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引用本文：

沈奇伟, 刘思颖, 花荣, 许博, 邵怡凯, 姚琪远. 代谢手术相关的组学研究方法及进展[J]. 中华肥胖与代谢病电子杂志, 2018, 04(04): 218-225.

Qiwei Shen, Siying Liu, Rong Hua. Methodology and progress of histology related to metabolic surgery[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2018, 04(04): 218-225.

表1 83种代谢产物在代谢手术前后的变化趋势及统计学差异
变化趋势 代谢物 功能组 校正后的统计学差异 趋势的统计学意义
T3 vs T0 T6 vs T0 T6 vs T3
ABC型 p-Cresol sulfate 对甲酚硫酸盐 氨基酸及相关 YES YES ? YES
Phosphatidylcholine No 02 磷脂酰胆碱 复合脂质及相关 ? YES ? ?
Choline plasmalogen(C18, C20:4) 缩醛磷脂胆碱 复合脂质及相关 ? YES ? ?
CBA型 Alanine 丙氨酸 氨基酸及相关 YES YES ? YES
BAB型 Taurine 牛磺酸 氨基酸及相关 YES ? YES YES
Asparagine 天冬氨酸 氨基酸及相关 YES ? YES YES
Citruline 瓜氨酸 氨基酸及相关 ? ? ? ?
myo-lnositol 肌醇 碳水化合物及相关 ? ? ? ?
Ribose 核糖 碳水化合物及相关 ? ? ? ?
Phophate (inorganic and from organic phosphates) 磷酸盐 混合 ? ? YES ?
Hypoxanthine (minor: Inosine) 次黄嘌呤 嘌呤，嘧啶及相关 YES ? ? ?
Histamine 组胺 儿茶酚胺及相关 ? ? YES ?
Lysophosphatidylcholine (C18:2) 溶血卵磷脂 复合脂质及相关 ? ? ? ?
Phosphatidylcholine (C18:1, C18:2) 磷脂酰胆碱 复合脂质及相关 YES ? ? ?
ABB型 Indole-3-acelic acid 吲哚乙酸 氨基酸及相关 ? ? ? ?
beta-Aminoisobutyrate β氨基丁酸 氨基酸及相关 ? YES ? ?
3-Hydroxyindole (minor: 3-Indoxylsulfuric acid) 3-羟基吲哚 氨基酸及相关 YES ? ? ?
Cystine 胱氨酸 氨基酸及相关 ? ? ? ?
3-Indoxylsulfuric acid 3-吲哚酚硫酸 氨基酸及相关 YES ? ? ?
Glycine 甘氨酸 氨基酸及相关 ? ? ? ?
Citrate (minor: Isocitrate) 柠檬酸盐 能量代谢及有机酸 YES ? ? ?
3-hydroxybutyrate 3-羟基丁酸 能量代谢及有机酸 YES ? ? ?
Docosahexaenoic acid (C22: cis[4,7,10,13,16,19]6) 二十二碳六烯酸 脂肪酸 ? ? ? ?
Nervonic acid (C24: cis[15]1) 神经酸 脂肪酸 YES ? ? ?
Elaidic acid (C18:trans[9]1) 异油酸 脂肪酸 ? ? ? ?
Arachidonic acid (C20:cis[5,8,11,14]4)] 花生四烯酸 脂肪酸 ? YES ? ?
DAG (C18:1, C18:2) 甘油二酯 复合脂质及相关 YES YES ? YES
Galactose, lipid fraction 半乳糖 复合脂质及相关 YES YES ? YES
N-Acelyneuraminic acid, lipid frction N-乙酰神经胺酸 复合脂质及相关 ? ? ? ?
Pseudouridine 假尿嘧啶核苷 嘌呤，嘧啶及相关 ? ? ? ?
Thyroxine (T4) 甲状腺素 混合 ? ? ? ?
Phosphaidylcholine (C18:2, C20:4) 磷脂酰胆碱 复合脂质及相关 YES YES ? YES
Phosphaidylcholine No 03 磷脂酰胆碱 复合脂质及相关 ? ? ? ?
Phosphaidylcholine (C16:0, C20:4) 磷脂酰胆碱 复合脂质及相关 ? ? ? ?
Phosphaidylcholine (C16:0, C16:0) 磷脂酰胆碱 复合脂质及相关 ? ? ? ?
Phosphaidylcholine (C18:0, C22:6) 磷脂酰胆碱 复合脂质及相关 YES YES ? YES
Phosphaidylcholine (C18:0, C18:2) 磷脂酰胆碱 复合脂质及相关 YES YES ? YES
3-O-Methylsphingosine (minor:Sphingolipids, erythro-Sphingosine, Threo-Sphingosine) 3-O-甲基鞘氨醇 复合脂质及相关 ? ? ? ?
Threo-Sphingosine (minor: Sphingolipids) 苏式-鞘氨醇 复合脂质及相关 ? ? ? ?
ABB型 5-O-Methylsphingosine (minor:Sphingolipids, erythro-Sphingosine, Threo-Sphingosine) 5-O-甲基鞘氨醇 复合脂质及相关 ? ? ? ?
Erythro-Sphingosine (minor: Sphingolipids) 赤式-鞘氨醇 复合脂质及相关 ? ? ? ?
erythro-Dihydrosphingosine 赤式-二氢鞘氨醇 复合脂质及相关 YES ? ? ?
ABA型 Mannose 甘露糖 碳水化合物及相关 ? ? ? ?
4-Hydroxy-3-methoxymandelic acid 4-羟基-3-甲氧基扁桃酸 儿茶酚胺及相关 ? ? ? ?
BAA型 Arginine 精氨酸 氨基酸及相关 ? YES ? ?
Phenylalanine 苯丙氨酸 氨基酸及相关 ? ? ? ?
Tyrosine 酪氨酸 氨基酸及相关 YES YES ? YES
Tryptophan 色氨酸 氨基酸及相关 ? ? ? ?
Kynurenic acid 犬尿酸 氨基酸及相关 YES YES ? YES
Threonine 苏氨酸 氨基酸及相关 YES YES ? YES
Lysine 赖氨酸 氨基酸及相关 YES YES ? YES
Serine 丝氨酸 氨基酸及相关 ? ? ? ?
Valine 缬氨酸 氨基酸及相关 YES YES ? YES
Isoleucine 异亮氨酸 氨基酸及相关 YES YES ? YES
Leucine 亮氨酸 氨基酸及相关 YES YES ? YES
Proline 脯氨酸 氨基酸及相关 ? ? ? ?
Indole-3-lactic acid 吲哚乙酸 氨基酸及相关 YES ? ? ?
Pentadecanol 十五烷醇 复合脂质及相关 YES YES ? YES
Lactate 乳酸盐 能量代谢及有机酸 YES ? ? ?
Palmitoleic acid (C16: cis[9]1) 棕榈油酸 脂肪酸 ? ? ? ?
Stearic acid (C18:0) 硬脂酸 脂肪酸 YES YES ? YES
Tricosanoic acid (C23:0) 二十三酸 脂肪酸 YES YES ? YES
Myristic acid (C14:0) 肉豆蔻酸 脂肪酸 YES ? ? ?
Behenic acid (C22:0) 二十二烷酸 脂肪酸 YES YES ? YES
gamma-Linolenic acid (C18: cis[6,9,12]3) γ-亚麻酸 脂肪酸 YES YES ? YES
TAG (C16:0, C16:1) 甘油三酯 复合脂质及相关 ? ? ? ?
beta-Sitosterol β-谷甾醇 混合 ? ? ? ?
Creatine 肌酸 混合 YES YES ? YES
Campesterol 菜油甾醇 混合 YES YES ? YES
Xanthine 黄嘌呤 嘌呤，嘧啶及相关 YES ? ? ?
Phosphatidylcholine (C16:1, C18:2) 磷脂酰胆碱 复合脂质及相关 ? ? ? ?
Phosphatidylcholine (C18:0, C18:1) 磷脂酰胆碱 复合脂质及相关 YES ? ? ?
Ceramide (d18:1/C24:0) 神经酰胺 复合脂质及相关 YES YES ? YES
erythro-C16-Sphingosine 赤式-C16-鞘氨醇 复合脂质及相关 YES YES ? YES
Coenzyme Q9 辅酶Q9 维生素、辅酶因子及相关 YES ? ? ?
AAB型 Canthaxanthin 角黄素 混合 ? YES ? ?
Lycopene 番茄红素 混合 ? ? ? ?
beta-Carotene β-胡萝卜素 维生素、辅酶因子及相关 ? YES ? ?
Threonic acid 苏糖酸 维生素、辅酶因子及相关 ? ? ? ?
Coenzyme Q10 辅酶Q10 维生素、辅酶因子及相关 ? ? ? ?
BBA型 Glutamate 谷氨酸盐 氨基酸及相关 ? YES ? ?
Glucose 葡萄糖 碳水化合物及相关 ? ? ? ?
Ascorbic acid 抗坏血酸（维生素C） 维生素、辅酶因子及相关 ? ? ? ?
表2 代谢手术前后外泌体micro RNA变化及相关通路
? Seed P fold-change No. targets in insulin signaling 相关胰岛素信号通路
miR-1227-3p GUGCCAC 0.02 2.23±0.35 2 PRKC1, SOCS3
miR-4691-5p UCCUCCA 0.03 1.98±0.09 2 PIK3C3, PRKAG1
miR-219a-5p GAUUGUC 0.02 1.80±0.19 8 GSK3B, OCRL, PIK3C3G, PPP1R114B, PRKCI, RAPGEF1, RHOQ, SHC1
miR-4728-3p AUGCUGA 0.02 1.64±0.20 2 EIF4E, MAPK1
miR-103-3p GCAGCAU 0.02 1.59±0.25 8 CRKL, IRS2, JAK1, PDE3B, PIK3R1, PRCKI, SOS1, SYNJ1
miR-3622a-3p CACCUGA 0.04 1.54±0.21 1 PIK3R6
miR-4749-3p GCCCCUC 0.03 1.53±0.31 2 PRKACA, RAPGEF1
miR-125b-5p CCCUGAG 0.01 1.50±0.28 10 ASIC1, EIF2B2, EIF4EBP1, GRB10, PIK3C2B, PIK3CD, PIK3R5, PPP1CA, RAF1, RHOQ
miR-3926 GGCCAAA 0.01 -1.52±0.31 1 PRKAR2B
miR-224-5p AAGUCAC 0.01 -1.53±0.12 5 CBL, CRKL, GSK3B, IRS2, PIK3R3
miR-4723-5p GGGGGAG 0.01 -1.58±0.08 6 AKT1, FOXO4, PIK3R2, PRKACA, RRAS, VAMP2
miR-16-5p AGCAGCA 0.02 -1.59±0.11 27 AKT3, CRKL, EIF2B5, EIF4E, FOXO1, GRB10, INSR, IRS1, IRS2, KRAS, LIPE, MAP2L1, MAPK3, MRAS, OCRL, PIK2C3A, PIK3R1, PPP1R11, PRKAR2A, RAF1, RAPGEF1, SGK1, SOS1, SOS2, SYNJ1, TRIP10, TSC1
miR-3690 CCUGGAC 0.01 -1.73±0.08 2 PIK3R5, SCNN1G
miR-208a-3p UAAGACG 0.01 -1.82±0.10 3 IRS2, PRKAR1A, SOS2
miR-4716-3p AGGGGGA 0.04 -1.87±0.12 3 AKT2 PRKACA, STBP4
miR-4525 GGGGGAU 0.04 -1.91±0.07 2 PRKACA, VAMP2
miR-2355-5p UCCCCAG 0.02 -1.93±0.12 4 CBL, FOXO4, PIK3CD, PPP1R3C
miR-4782-5p UCUGGAU 0.02 -2.29±0.16 1 GYS1
表3 相关数据库及其地址
? 名称 URL
一般基因表达数据 ArrayExpress http://www.ebi.ac.uk/arrayexpress/
GEO http://www.ncbi.nlm.nih.gov/geo/
caArray https://cabig.nci.nih.gov/tools/caArray
Gene Expression Database (GXD) http://www.informatics.jax.org/mgihome/ GXD/aboutGXD.shtml
Stanford Microarray Database (SMD) http://smd.stanford.edu/about.shtml
RNA Abundance Database (RAD) http://www.cbil.upenn.edu/RAD/
Genomics Portals http://www.genomicsportals.org
蛋白和蛋白组学 PRoteomics IDEntifications (PRIDE) http://www.ebi.ac.uk/pride/
Uniprot http://www.ebi.ac.uk/uniprot/
Human Protein Atlas http://www.proteinatlas.org/
Entrez Protein http://www.ncbi.nlm.nih.gov/protein
Secreted Protein Database http://spd.cbi.pku.edu.cn/
Lipid MAPS http://www.lipidmaps.org/
Lipase Engineering Database http://www.led.uni-stuttgart.de/
代谢组学 The Human Metabolome Database (HMDB) http://www.hmdb.ca/
Madison-Qingdao Metabolomics Consortium Database http://mmcd.nmrfam.wisc.edu/
Clinical Trials.gov http://www.clinicaltrials.gov/
Clinical Study Results http://www.clinicalstudyresults.org/home/
基因 Entrez Gene http://www.ncbi.nlm.nih.gov/gene
UCSC Genome Browser http://genome.ucsc.edu/
代谢通路、网络、基因功能 Gene Ontology http://geneontology.org/
BioCarta http://www.biocarta.com/ genes/allPathways.asp
BioCyc http://biocyc.org/
Genomics of Lipid-associated Disorders (GOLD.db) https://gold.tugraz.at/
KEGG http://www.genome.jp/kegg/
MetaCyc http://metacyc.org/
EndoNet http://endonet.bioinf.med. uni-goettingen.de/
Reactome http://www.reactome.org
GeneRIF http://www.ncbi.nlm.nih.gov/ gene/about-generif
基因关联 dbSNP http://www.ncbi.nlm.nih.gov/SNP/
MGD http://www.informatics.jax.org/
Mouse Phenome database http://phenome.jax.org/
Online Mendelian Inheritance in Man (OMIM) http://www.ncbi.nlm.nih.gov/omim
PhenomicDB http://www.phenomicdb.de/
Catalog of Published Genome-Wide Association Studies http://genome.gov/gwastudies/
NIH Genetic Association Database http://geneticassociationdb.nih.gov/
HuGE Navigator http://hugenavigator.net/
NCBI database of Genotypes and Phenotypes (dbGaP) http://www.ncbi.nlm.nih.gov/gap
药效基因组学 PharmGKB http://www.pharmgkb.org/
DrugBank: GenoBrowse http://www.drugbank.ca/ genobrowse/snp-adr
Drug interaction database http://www.druginteractioninfo.org/
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