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Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition) ›› 2025, Vol. 11 ›› Issue (01): 53-61. doi: 10.3877/cma.j.issn.2095-9605.2025.01.008

• Articles • Previous Articles    

Association of BMI,type 2 diabetes,lifestyle factors with gastroesophageal reflux disease:A twosample Mendelian randomization study

Jianing Gu1, Guoda Han2, Haoran Yan1, Zhengqi Li3, Liang Wang2,()   

  1. 1. Cangzhou Central Hospital,Hebei Medical University,Cangzhou 061000,China
    2. Department of Gastrointestinal Surgery I,Cangzhou Central Hospital,Cangzhou 061000,China
    3. Caiyi Community Health Service Center of Huabei Oilfield,Renqiu 062550,China
  • Received:2024-10-15 Online:2025-02-28 Published:2025-04-22
  • Contact: Liang Wang

Abstract:

Objective

The purpose of this study was to investigate the potential causal relationship between gastroesophageal reflux disease (GERD) and BMI,type 2 diabetes,lifestyle factors.

Methods

We extracted single nucleotide polymorphisms (SNPs) associated with various exposure factors and GERD from the GWAS database by two-sample Mendelian randomization analysis (MR),and selected appropriate instrumental variables (IVs).The phenotypic data of IVs were searched through the Ensemble website to exclude SNPs associated with confounding factors.In this study,five statistical methods such as inverse variance weighting (IVW),weighted median (MW),MR Egger method were used for data analysis,and heterogeneity,level multi-effect test and sensitivity analysis were carried out.Odds ratio (OR) and 95 %confidence interval (CI) were used to assess the causal association between GERD and BMI,type 2 diabetes,lifestyle factors.

Results

There was a positive causal relationship between between GERD and BMI,type 2 diabetes,lifestyle factors:1.66 (95%CI:1.39~1.97),1.05 (95%CI:1.02~1.09),3.03 (95%CI:2.36~3.89),1.78(95%CI:1.57~2.03),1.22 (95%CI:1.03~1.44),respectively.

Conclusions

BMI,type 2 diabetes,smoking,drinking,and coffee intake had genetic evidence associated with GERD risk.

Key words: Body mass index, lifestyle factors, Gastroesophageal reflux disease, Mendel randomization

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