The eating duration was reduced by intestinal electrical stimulation in obese rats

doi:10.3877/cma.j.issn.2095-9605.2022.02.004

Abstract

Abstract:

Objective

Investigating the mechanism of intestinal electrical stimulation (IES) induced weight loss in obese rats by observing the changes of meal pattern.

Methods

Sixteen diet-induced obese rats (DIO) were used in the experiment. The BioDAQ system was used to record events of food intake. And the changes of meal pattern of obese rats with different stimulation duration (0 h, 1 h, 6 h and 12 h) were compared. Lastly, the levels of serum glucagon-like peptide-1 (GLP-1) and Leptin were tested by enzyme-linked immunosorbent assay (ELISA).

Results

The average daily food intake with four different stimulation duration were (22.3±2.9) g, (21.9±3.7) g, (19.6±4.3) g and (17.5±5.1) g, respectively. This was a stimulation time-dependent downward trend. There was no significant difference in the average daily feeding times of rats, but the eating duration were significantly shortened, and the average eating duration of 12hours stimulation (IES-12h) was significantly shorter than that of IES-0h, (112.8±50.3) min vs.(147.9±52.1) min. When DIO rats received one hour stimulation, the level of postprandial serum GLP-1 was significantly higher than that of sham-IES, but there was no difference on the level of Leptin between the two groups.

Conclusions

IES caused the weight loss of obese rats by reducing the eating duration, and GLP-1 may play a role in it.

Key words: Intestinal electrical stimulation, Obesity, Glucagon-like peptide-1, Mechanism

Xiaoling Ye, Yu Zhang, Xinyue Wan. The eating duration was reduced by intestinal electrical stimulation in obese rats[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(02): 93-96.

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References 16

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进食模式	分组
进食模式	IES-0h	IES-1h	IES-6h	IES-12h
平均进食次数	4.5±0.9	4.4±1.1	4.4±0.8	4.2±1.1
平均进食时间（min）	147.9±52.1	151.1±50.5	123.7±57.4^*	112.8±50.3^*
平均进食量（g）	22.3 ± 2.9	21.9 ± 3.7	19.6 ± 4.3^*	17.5 ± 5.1^*

进食模式	分组
进食模式	IES-0h	IES-1h	IES-6h	IES-12h
平均进食次数	4.5±0.9	4.4±1.1	4.4±0.8	4.2±1.1
平均进食时间（min）	147.9±52.1	151.1±50.5	123.7±57.4^*	112.8±50.3^*
平均进食量（g）	22.3 ± 2.9	21.9 ± 3.7	19.6 ± 4.3^*	17.5 ± 5.1^*

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