Correlation analysis between fructosamine and postprandial blood glucose and glycemic variability

doi:10.3877/cma.j.issn.2095-9605.2017.02.005

Abstract

Abstract:

Objective

To investigate the correlation between fructosamine (FA) and postprandial hyperglycemia and glycemic variability.

Methods

Clinical data of 30 type 2 diabetes mellitus (T2DM) patients (the patient group) treated in the Endocrinology Department and 30 healthy subjects (the control group) undergoing physical examination in the Outpatient Clinic of the Second People’s Hospital of Liaocheng from June 2012 to June 2014 were retrospectively studied. The informed consents of all the subjects were obtained and the local ethical committee approval had been received. In the patient group, 14 were males and 16 were females with an average age of (55±9) years old; and in the control group, 13 were males and 17 were females with an average age of (56±10) years old. The indexes of glycosylated hemoglobin A1c (HbA1c), FA, serum creatinine and serum albumin in the fasting state and urinary albumin excretion rate were compared between the two groups. In the meanwhile, the indexes of postprandial blood glucose, mean postprandial maximum glucose (MPMG), standard deviation of blood glucose (SDBG), area under the curve of level above 10 mmol/L (AUC-10) and mean amplitude of glycemic excursions (MAGE) showed by arterial glucometer were also compared. The comparisons between the two groups were conducted using t test or χ² test, and the correlation analyses between FA and 24-hour average blood glucose, SDBG, MPMG, AUC-10 and MAGE were conducted using Pearson Correlation Analysis.

Results

The levels of FA, SDBG, MPMG and MAGE in the patient group were (3.1±1.2) (1.8±0.6) (10.4±1.4) and (4.2±1.5) mmol/L respectively, which were significantly higher than (2.2±0.5) (1.2±0.3) (7.4±1.2) and (3.1±1.4) mmol/L of those subjects in the control group (P<0.05). FA and HbA1c of subjects in the control group were positively correlated with the 24-hour average blood glucose, SDBG, MPMG, AUC-10 and MAGE (P<0.05). FA of the subjects in the patient group was positively correlated with the 24-hour average blood glucose, MPMG, AUC-10 and MAGE (P<0.05), but HbA1c was only positively correlated with the 24-hour average blood glucose (P<0.05).

Conclusion

For T2DM patients with HbA1c at the normal level, FA is positively correlated with the indexes reflecting postprandial hyperglycemia and glycemic variability, so it is an efficient feature to predict postprandial hyperglycemia and glycemic variability.

Key words: Diabetes mellitus, Type 2, Fructosamine, Glycemic variability, Postprandial hyperglycemia

Baoqiang Guo, Xiuli Xu, Tao Liu, Shan Yu. Correlation analysis between fructosamine and postprandial blood glucose and glycemic variability[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2017, 03(02): 78-81.

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References 9

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组别	例数	性别（例）		年龄（岁，±s）	BMI （kg/m²，±s）	HbA1c （%，±s）	肌酐（umol /L，±s）	血清白蛋白（g/L，±s）
组别	例数	男	女	年龄（岁，±s）	BMI （kg/m²，±s）	HbA1c （%，±s）	肌酐（umol /L，±s）	血清白蛋白（g/L，±s）
病例组	30	14	16	55±9	26±6	5.9±0.8	76±12	42±5
对照组	30	13	17	56±10	25±5	5.5±0.7	71±12	40±5
统计值	?	χ²=0.067		t=0.37	t=0.62	t=0.58	t=0.44	t=0.52
P值	?	>0.05		>0.05	>0.05	>0.05	>0.05	>0.05
组别	例数	尿白蛋白排泄率（ug/min，±s）	FA （mmol/L，±s）	SDBG （mmol/L，±s）	MPMG （mmol/L，±s）	MAGE （mmol/L，±s）
病例组	30	6.9±1.8	3.1±1.2	1.8±0.6	10.4±1.4	4.2±1.5
对照组	30	5.8±2.0	2.2±0.5	1.2±0.3	7.4±1.2	3.1±1.4
统计值	?	t=0.49	t=3.15	t=2.152	t=2.95	t=2.42
P值	?	>0.05	<0.05	<0.05	<0.05	<0.05

组别	例数	性别（例）		年龄（岁，±s）	BMI （kg/m²，±s）	HbA1c （%，±s）	肌酐（umol /L，±s）	血清白蛋白（g/L，±s）
组别	例数	男	女	年龄（岁，±s）	BMI （kg/m²，±s）	HbA1c （%，±s）	肌酐（umol /L，±s）	血清白蛋白（g/L，±s）
病例组	30	14	16	55±9	26±6	5.9±0.8	76±12	42±5
对照组	30	13	17	56±10	25±5	5.5±0.7	71±12	40±5
统计值	?	χ²=0.067		t=0.37	t=0.62	t=0.58	t=0.44	t=0.52
P值	?	>0.05		>0.05	>0.05	>0.05	>0.05	>0.05
组别	例数	尿白蛋白排泄率（ug/min，±s）	FA （mmol/L，±s）	SDBG （mmol/L，±s）	MPMG （mmol/L，±s）	MAGE （mmol/L，±s）
病例组	30	6.9±1.8	3.1±1.2	1.8±0.6	10.4±1.4	4.2±1.5
对照组	30	5.8±2.0	2.2±0.5	1.2±0.3	7.4±1.2	3.1±1.4
统计值	?	t=0.49	t=3.15	t=2.152	t=2.95	t=2.42
P值	?	>0.05	<0.05	<0.05	<0.05	<0.05

组别	例数	与FA的相关系数r					与HbA1c的相关系数r
组别	例数	24 h平均血糖	MPMG	AUC-10	SDBG	MAGE	24 h平均血糖	MPMG	AUC-10	SDBG	MAGE
病例组	30	0.485^*	0.321^*	0.410^*	0.096	0.671^*	0.718^*	0.138	0.089	0.175	0.092
对照组	30	0.504^*	0.372^*	0.489^*	0.210^*	0.634^*	0.812^*	0.516^*	0.498^*	0.387^*	0.512^*

组别	例数	与FA的相关系数r					与HbA1c的相关系数r
组别	例数	24 h平均血糖	MPMG	AUC-10	SDBG	MAGE	24 h平均血糖	MPMG	AUC-10	SDBG	MAGE
病例组	30	0.485^*	0.321^*	0.410^*	0.096	0.671^*	0.718^*	0.138	0.089	0.175	0.092
对照组	30	0.504^*	0.372^*	0.489^*	0.210^*	0.634^*	0.812^*	0.516^*	0.498^*	0.387^*	0.512^*

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