Research progress on molecular mechanism of obesity complicated with gastroesophageal reflux disease

doi:10.3877/cma.j.issn.2095-9605.2025.04.012

Abstract

Abstract:

Obesity is an established independent risk factor for gastroesophageal reflux disease (GERD) and hiatal hernia. Although the relationship between obesity and these conditions has been clarified from anatomical and physiological perspectives, the underlying molecular mechanisms require further elucidation. This review aims to systematically summarize current research progress on the molecular mechanisms driving obesity-induced GERD, with a focus on the interplay among inflammatory microenvironments, metabolic reprogramming, intestinal flora dysbiosis, and related signaling pathways. This integrated perspective seeks to enhance understanding of the pathophysiology and thereby inform novel clinical prevention and treatment strategies.

Key words: Obesity, BMI, Gastroesophageal reflux disease, Hiatal hernia, Cytokines, Molecular mechanism

Jiaxin Wen, Aili Aikebaier·. Research progress on molecular mechanism of obesity complicated with gastroesophageal reflux disease[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2025, 11(04): 337-343.

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