The pan-vascular disease has become a major public health problem that needs to be solved urgently, with the atherosclerotic cardiovascular disease has become a major cause of death and disability worldwide. Systematic prevention and treatment and targeted intervention are the key points in the diagnosis and treatment concept of pan-vascular diseases. High body weight variability is an important risk factor for the risk of pan-vascular disease and all-cause mortality and is independent of baseline weight levels. High body weight variability increases the occurrence and development of adverse vascular events such as cardiac and cerebrovascular events and type diabetic vascular disease, and predicts the poor prognosis of patients. In patient-centered comprehensive health management, it is important to pay attention to the long-term stability of weight control while paying attention to weight, which is of great significance to further reduce the occurrence and development of pan-vascular diseases.