Comparative analysis of serum metabolic hormone profiles in obese and non-obese populations

doi:10.3877/cma.j.issn.2095-9605.2025.02.003

Abstract

Abstract:

Objective

To investigate the differences in the serum metabolic hormone profiles between obese and non-obese individuals and their correlations with other basic indicators.

Methods

A total of 67 obese patients (BMI≥28 kg/m²) and 24 healthy controls (BMI 18~27 kg/m²) who received medical care between September 2023 and June 2024 were enrolled in this study. Serum hormone levels were measured using enzyme-linked immunosorbent assay (ELISA). Differences between obese and non-obese individuals were evaluated using independent samples t-tests, and Pearson correlation analysis was performed to assess the relationships between various hormones and baseline clinical parameters.

Results

Obese individuals exhibited characteristic hormonal imbalances, with significantly elevated levels of adiponectin, obestatin, and advanced oxidation protein products (AOPPs) (P<0.05), while levels of visfatin and glucagon-like peptide-1 (GLP-1) were markedly reduced in the obese group (P<0.05). No significant differences were observed in the remaining hormones between obese and non-obese individuals. Pearson correlation analysis revealed negative correlations between visfatin and ghrelin levels and transaminase levels (P<0.05).

Conclusions

Compared with non-obese individuals, obese individuals exhibit abnormal hormone secretion profiles, which may underlie the metabolic dysregulation associated with obesity.

Key words: Hormones, Obesity, Metabolic syndrome, Metabolic dysregulation, Biomarkers

Ruibin Zheng, Xiangwen Zhao. Comparative analysis of serum metabolic hormone profiles in obese and non-obese populations[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2025, 11(02): 100-103.

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Figures/Tables 2

References 16

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项目	非肥胖组（n=24）	肥胖组（n=67）	t值	P值
年龄（岁）	38.63±9.77	34.25±9.61	1.904	0.060
BMI（kg/m²）	23.35±2.45	39.47±7.19	-15.951	<0.001
空腹血糖（mmol/L）	5.14±1.52	5.43±1.79	-0.713	0.477
白细胞（×10⁹/L）	7.98±4.12	8.25±2.06	-0.310	0.759
中性粒细胞计数（×10⁹/L）	5.58±4.00	5.15±1.73	0.513	0.612
淋巴细胞计数（×10⁹/L）	1.79±0.53	2.39±0.67	-3.945	<0.001
血小板计数（×10⁹/L）	270.75±75.59	280.70±77.04	-0.544	0.588
单核细胞计数（×10⁹/L）	0.46±0.24	0.49±0.15	-0.493	0.626
ALT（U/L）	17.32±10.53	43.37±50.92	-3.931	<0.001
AST（U/L）	20.10±11.78	31.18±28.36	-1.851	0.067
ADP（mmol/L）	446.56±163.30	590.00±299.66	-2.897	0.005
AOPP（mmol/L）	13.34±5.73	18.33±11.48	-2.615	0.011
AP（mmol/L）	2159.12±749.93	1765.63±673.40	2.383	0.019
CHE（mmol/L）	6.25±4.22	7.43±4.71	-1.086	0.280
GLP-1（mmol/L）	2.85±0.94	2.43±0.82	2.048	0.044
GH（mmol/L）	532.55±130.38	500.98±229.90	0.636	0.527
LEP（mmol/L）	3.43±1.12	3.22±1.57	0.594	0.554
INH（mmol/L）	347.82±83.62	401.19±158.00	-2.071	0.042
OM-1（mmol/L）	179.29±74.92	162.19±70.20	1.006	0.317

项目	非肥胖组（n=24）	肥胖组（n=67）	t值	P值
年龄（岁）	38.63±9.77	34.25±9.61	1.904	0.060
BMI（kg/m²）	23.35±2.45	39.47±7.19	-15.951	<0.001
空腹血糖（mmol/L）	5.14±1.52	5.43±1.79	-0.713	0.477
白细胞（×10⁹/L）	7.98±4.12	8.25±2.06	-0.310	0.759
中性粒细胞计数（×10⁹/L）	5.58±4.00	5.15±1.73	0.513	0.612
淋巴细胞计数（×10⁹/L）	1.79±0.53	2.39±0.67	-3.945	<0.001
血小板计数（×10⁹/L）	270.75±75.59	280.70±77.04	-0.544	0.588
单核细胞计数（×10⁹/L）	0.46±0.24	0.49±0.15	-0.493	0.626
ALT（U/L）	17.32±10.53	43.37±50.92	-3.931	<0.001
AST（U/L）	20.10±11.78	31.18±28.36	-1.851	0.067
ADP（mmol/L）	446.56±163.30	590.00±299.66	-2.897	0.005
AOPP（mmol/L）	13.34±5.73	18.33±11.48	-2.615	0.011
AP（mmol/L）	2159.12±749.93	1765.63±673.40	2.383	0.019
CHE（mmol/L）	6.25±4.22	7.43±4.71	-1.086	0.280
GLP-1（mmol/L）	2.85±0.94	2.43±0.82	2.048	0.044
GH（mmol/L）	532.55±130.38	500.98±229.90	0.636	0.527
LEP（mmol/L）	3.43±1.12	3.22±1.57	0.594	0.554
INH（mmol/L）	347.82±83.62	401.19±158.00	-2.071	0.042
OM-1（mmol/L）	179.29±74.92	162.19±70.20	1.006	0.317

项目	ADP		AOPP		AP		CHE		GLP-1		GH		LEP		INH		OM-1
项目	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值
年龄（岁）	0.013	0.906	0.058	0.597	-0.028	0.792	-0.03	0.777	-0.089	0.404	0.045	0.671	0.042	0.691	-0.024	0.821	0.040	0.704
BMI（kg/m²）	0.039	0.715	0.047	0.670	-0.217	0.038	-0.004	0.973	-0.144	0.178	-0.142	0.178	-0.168	0.111	0.018	0.868	-0.121	0.254
空腹血糖（mmol/L）	0.104	0.328	0.076	0.489	0.048	0.651	0.098	0.354	-0.130	0.223	0.090	0.394	0.103	0.330	0.131	0.217	0.052	0.625
白细胞（×10⁹/L）	0.072	0.502	-0.032	0.772	0.126	0.236	0.029	0.788	0.169	0.115	0.069	0.515	0.075	0.482	0.072	0.499	0.048	0.656
中性粒细胞计数（×10⁹/L）	0.026	0.806	-0.073	0.506	0.112	0.294	-0.038	0.722	0.148	0.169	0.047	0.660	0.054	0.614	0.032	0.765	0.025	0.814
淋巴细胞计数（×10⁹/L）	0.106	0.319	0.073	0.507	0.027	0.801	0.185	0.082	0.056	0.603	0.054	0.616	0.044	0.681	0.116	0.277	0.028	0.795
血小板计数（×10⁹/L）	0.054	0.616	-0.023	0.835	0.089	0.403	0.069	0.519	0.162	0.132	0.136	0.202	0.017	0.874	0.035	0.741	0.083	0.437
单核细胞计数（×10⁹/L）	0.041	0.704	-0.008	0.939	0.019	0.856	-0.047	0.661	0.012	0.910	-0.023	0.829	0.040	0.705	0.010	0.928	0.017	0.870
ALT（U/L）	-0.161	0.129	-0.147	0.178	-0.220	0.037	-0.136	0.200	-0.204	0.057	-0.234	0.026	-0.205	0.053	-0.139	0.192	-0.173	0.104
AST（U/L）	-0.171	0.108	-0.179	0.102	-0.209	0.049	-0.145	0.172	-0.163	0.128	-0.257	0.019	-0.203	0.055	-0.169	0.111	-0.163	0.124

项目	ADP		AOPP		AP		CHE		GLP-1		GH		LEP		INH		OM-1
项目	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值	Pearson系数	P值
年龄（岁）	0.013	0.906	0.058	0.597	-0.028	0.792	-0.03	0.777	-0.089	0.404	0.045	0.671	0.042	0.691	-0.024	0.821	0.040	0.704
BMI（kg/m²）	0.039	0.715	0.047	0.670	-0.217	0.038	-0.004	0.973	-0.144	0.178	-0.142	0.178	-0.168	0.111	0.018	0.868	-0.121	0.254
空腹血糖（mmol/L）	0.104	0.328	0.076	0.489	0.048	0.651	0.098	0.354	-0.130	0.223	0.090	0.394	0.103	0.330	0.131	0.217	0.052	0.625
白细胞（×10⁹/L）	0.072	0.502	-0.032	0.772	0.126	0.236	0.029	0.788	0.169	0.115	0.069	0.515	0.075	0.482	0.072	0.499	0.048	0.656
中性粒细胞计数（×10⁹/L）	0.026	0.806	-0.073	0.506	0.112	0.294	-0.038	0.722	0.148	0.169	0.047	0.660	0.054	0.614	0.032	0.765	0.025	0.814
淋巴细胞计数（×10⁹/L）	0.106	0.319	0.073	0.507	0.027	0.801	0.185	0.082	0.056	0.603	0.054	0.616	0.044	0.681	0.116	0.277	0.028	0.795
血小板计数（×10⁹/L）	0.054	0.616	-0.023	0.835	0.089	0.403	0.069	0.519	0.162	0.132	0.136	0.202	0.017	0.874	0.035	0.741	0.083	0.437
单核细胞计数（×10⁹/L）	0.041	0.704	-0.008	0.939	0.019	0.856	-0.047	0.661	0.012	0.910	-0.023	0.829	0.040	0.705	0.010	0.928	0.017	0.870
ALT（U/L）	-0.161	0.129	-0.147	0.178	-0.220	0.037	-0.136	0.200	-0.204	0.057	-0.234	0.026	-0.205	0.053	-0.139	0.192	-0.173	0.104
AST（U/L）	-0.171	0.108	-0.179	0.102	-0.209	0.049	-0.145	0.172	-0.163	0.128	-0.257	0.019	-0.203	0.055	-0.169	0.111	-0.163	0.124

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