Research progress on the relationship between obesity and osteoporosis

doi:10.3877/cma.j.issn.2095-9605.2022.04.010

Abstract

Abstract:

With the aging of the population and changes in lifestyle, the incidence of chronic diseases such as obesity and osteoporosis continues to rise, which has become a major public health problem that threatens the health of residents. Studies have reported a close relationship between obesity and osteoporosis, and the underlying regulatory mechanisms are complex. This article will review the relationship between obesity and osteoporosis from two levels of epidemiological investigation and cellular and molecular mechanisms, further clarify the important factors that obesity affects bone health (Figure 1), and preliminarily explore the mutual influence of adipose tissue and skeletal system (Figure 2), providing a theoretical basis for health management and clinical research of comorbid populations.

Key words: Obesity, Overweight, Osteoporosis, Fractures

Feilong He, Jiajie Zang, Chunfeng Wu. Research progress on the relationship between obesity and osteoporosis[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(04): 277-282.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhfpydxbdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-9605.2022.04.010

https://zhfpydxbdzzz.cma-cmc.com.cn/EN/Y2022/V08/I04/277

Figures/Tables 2

References 61

[1]	WHO. Obesity and overweight [EB/OL]. (2021-06-30) [2022/08/16]. URL
[2]	中国疾病预防控制中心营养数据年鉴. 超重肥胖 [EB/OL]. [2022/08/16]. URL
[3]	Aspray TJ, Hill TR. Osteoporosis and the Ageing Skeleton [J]. Subcell Biochem, 2019, 91: 453-476.
[4]	国家卫生健康委员会. 首次中国居民骨质疏松症流行病学调查结果 [EB/OL]. (2018-10-19) [2022/8/16]. URL
[5]	Yu F, Xia W. The epidemiology of osteoporosis, associated fragility fractures, and management gap in China [J]. Arch Osteoporos, 2019, 14(1): 32.
[6]	Gkastaris K, Goulis DG, Potoupnis M, et al. Obesity, osteoporosis and bone metabolism [J]. J Musculoskelet Neuronal Interact, 2020, 20(3): 372-381.
[7]	Premaor MO, Comim FV, Compston JE. Obesity and fractures [J]. Arquivos Brasileiros de Endocrinologia & Metabologia, 2014, 5(58): 470-477.
[8]	Curtis EM, Moon RJ, Harvey NC, et al. The impact of fragility fracture and approaches to osteoporosis risk assessment worldwide [J]. Bone, 2017, 104: 29-38.
[9]	Fassio A, Idolazzi L, Rossini M, et al. The obesity paradox and osteoporosis [J]. Eat Weight Disord, 2018, 23(3): 293-302.
[10]	Rinonapoli G, Pace V, Ruggiero C, et al. Obesity and bone: a complex relationship [J]. Int J Mol Sci, 2021, 22(24): 13662.
[11]	Proietto J. Obesity and Bone [J]. F1000Res, 2020, 9: 1111.
[12]	[Walsh JS, Vilaca T. Obesity, type 2 diabetes and bone in adults [J]. Calcif Tissue Int, 2017, 100(5): 528-535.
[13]	Evans AL, Paggiosi MA, Eastell R, et al. Bone density, microstructure and strength in obese and normal weight men and women in younger and older adulthood [J]. J Bone Miner Res, 2015, 30(5): 920-928.
[14]	Jose A, Cherian KE, Nandyal MB, et al. Trabecular bone score and bone mineral density in postmenopausal women with morbid obesity-a clinical paradox [J]. Med Sci (Basel), 2021, 9(4): 69.
[15]	Li Y. Association between obesity and bone mineral density in middle-aged adults [J]. J Orthop Surg Res, 2022, 17(1): 268.
[16]	Hajihosseinali M, Arjmand N, Shirazi-Adl A. Effect of body weight on spinal loads in various activities: a personalized biomechanical modeling approach [J]. J Biomech, 2015, 48(2): 276-282.
[17]	Ghezelbash F, Shirazi-Adl A, Plamondon A, et al. Obesity and obesity shape markedly influence spine biomechanics: a subject-specific risk assessment model [J]. Ann Biomed Eng, 2017, 45(10): 2373-2382.
[18]	Turcotte AF, O'Connor S, Morin SN, et al. Association between obesity and risk of fracture, bone mineral density and bone quality in adults: a systematic review and meta-analysis [J]. PLoS One, 2021, 16(6): e252487.
[19]	Yi SW, Bae JH, Kim YM, et al. Relationship between body mass index and fracture risk at different skeletal sites: a nationwide cohort study [J]. Arch Osteoporos, 2022, 17(1): 99.
[20]	Hjelle AM, Apalset EM, Gjertsen JE, et al. Associations of overweight, obesity and osteoporosis with ankle fractures [J]. BMC Musculoskelet Disord, 2021, 22(1): 723.
[21]	Li X, Gong X, Jiang W. Abdominal obesity and risk of hip fracture: a meta-analysis of prospective studies [J]. Osteoporos Int, 2017, 28(10): 2747-2757.
[22]	Benedick A, Audet MA, Vallier HA. The effect of obesity on post-operative complications and functional outcomes after surgical treatment of torsional ankle fracture: A matched cohort study [J]. Injury, 2020, 51(8): 1893-1898.
[23]	Chaudhry YP, Rao SS, Puvanesarajah V, et al. Complications and 30-day mortality rate after hip fracture surgery in superobese patients [J]. J Orthop Trauma, 2021, 35(6): 322-328.
[24]	Chaves PDHN, de Lima CI, Chaves DHLC, et al. Fracture risk after bariatric surgery: a systematic literature review and meta-analysis [J]. Endocr Pract, 2022, 28(1): 58-69.
[25]	Mele C, Caputo M, Ferrero A, et al. Bone response to weight loss following bariatric surgery [J]. Front Endocrinol (Lausanne), 2022, 13: 921353.
[26]	Paccou J, Caiazzo R, Lespessailles E, et al. Bariatric surgery and osteoporosis [J]. Calcif Tissue Int, 2022, 110(5): 576-591.
[27]	Zouhal H, Berro AJ, Kazwini S, et al. Effects of exercise training on bone health parameters in individuals with obesity: a systematic review and meta-analysis [J]. Front Physiol, 2021, 12: 807110.
[28]	Molina J, Morgan EL. Obesity and Orthopedic Issues [J]. 2022.
[29]	Himes C L, Reynolds S L. Effect of obesity on falls, injury, and disability [J]. J Am Geriatr Soc, 2012, 60(1): 124-129.
[30]	Neri GR, Oliveira Silvia S, Dario Juliana B, et al. Does obesity increase the risk and severity of falls in people aged 60 years and older? A systematic review and meta-analysis of observational studies [J]. J Gerontol A Biol Sci Med Sci, 2020, 75(5): 952-960.
[31]	Mitchell R J, Lord S R, Harvey L A, et al. Obesity and falls in older people: mediating effects of disease, sedentary behavior, mood, pain and medication use [J]. Arch Gerontol Geriatr, 2015, 60(1): 52-58.
[32]	Garcia PA, Queiroz LL, Caetano M, et al. Obesity is associated with postural balance on unstable surfaces but not with fear of falling in older adults [J]. Braz J Phys Ther, 2021, 25(3): 311-318.
[33]	Blain H, Miot S, Bernard PL. How can we prevent falls? [J]. 2021: 273-290.
[34]	Ilich JZ, Kelly OJ, Inglis JE, et al. Interrelationship among muscle, fat, and bone: connecting the dots on cellular, hormonal, and whole body levels [J]. Ageing Res Rev, 2014, 15: 51-60.
[35]	Szlejf C, Parra-Rodriguez L, Rosas-Carrasco O. Osteosarcopenic obesity: Prevalence and relation with frailty and physical performance in middle-aged and older women [J]. J Am Med Dir Assoc, 2017, 18(8): 731-733.
[36]	Ilich JZ, Inglis JE, Kelly OJ, et al. Osteosarcopenic obesity is associated with reduced handgrip strength, walking abilities, and balance in postmenopausal women [J]. Osteoporos Int, 2015, 26(11): 2587-2595.
[37]	Scott D, Seibel M, Cumming R, et al. Does combined osteopenia/osteoporosis and sarcopenia confer greater risk of falls and fracture than either condition alone in older men? the concord health and ageing in men project [J]. J Gerontol A Biol Sci Med Sci, 2019, 74(6): 827-834.
[38]	Nie YZ, Yan ZQ, Yin H, et al. Osteosarcopenic obesity and its components-osteoporosis, sarcopenia, and obesity-are associated with blood cell count-derived inflammation indices in older Chinese people [J]. BMC Geriatr, 2022, 22(1): 532.
[39]	Kelly OJ, Gilman JC, Boschiero D, et al. Osteosarcopenic obesity: current knowledge, revised identification criteria and treatment principles [J]. Nutrients, 2019, 11(4).
[40]	Cheung YM, Joham A, Marks S, et al. The obesity paradox: an endocrine perspective [J]. Intern Med J, 2017, 47(7): 727-733.
[41]	Obradovic M, Sudar-Milovanovic E, Soskic S, et al. Leptin and Obesity: Role and Clinical Implication [J]. Front Endocrinol (Lausanne), 2021, 12: 585887.
[42]	Chen XX, Yang T. Roles of leptin in bone metabolism and bone diseases [J]. J Bone Miner Metab, 2015, 33(5): 474-485.
[43]	Bao D, Ma Y, Zhang X, et al. Preliminary characterization of a leptin receptor knockout rat created by CRISPR/Cas9 System [J]. Sci Rep, 2015, 5: 15942.
[44]	Lee NJ, Qi Y, Enriquez RF, et al. Energy partitioning between fat and bone mass is controlled via a hypothalamic leptin/NPY relay [J]. Int J Obes (Lond), 2020, 44(10): 2149-2164.
[45]	Kirk B, Feehan J, Lombardi G, et al. Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines [J]. Curr Osteoporos Rep, 2020, 18(4): 388-400.
[46]	Choi HM, Doss HM, Kim KS. Multifaceted physiological roles of adiponectin in inflammation and diseases [J]. Int J Mol Sci, 2020, 21(4).
[47]	Yang J, Park OJ, Kim J, et al. Adiponectin deficiency triggers bone loss by up-regulation of osteoclastogenesis and down-regulation of osteoblastogenesis [J]. Front Endocrinol (Lausanne), 2019, 10: 815.
[48]	Leeners B, Geary N, Tobler PN, et al. Ovarian hormones and obesity [J]. Hum Reprod Update, 2017, 23(3): 300-321.
[49]	Walsh JS, Evans AL, Bowles S, et al. Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health [J]. Am J Clin Nutr, 2016, 103(6): 1465-1471.
[50]	Samuel L, Borrell LN. The effect of body mass index on optimal vitamin D status in U.S. adults: the National Health and Nutrition Examination Survey 2001-2006 [J]. Ann Epidemiol, 2013, 23(7): 409-414.
[51]	Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity [J]. Am J Physiol Cell Physiol, 2021, 320(3): C375-C391.
[52]	Oliveira MC, Vullings J, van de Loo F. Osteoporosis and osteoarthritis are two sides of the same coin paid for obesity [J]. Nutrition, 2020, 70: 110486.
[53]	Kitaura H, Marahleh A, Ohori F, et al. Osteocyte-related cytokines regulate osteoclast formation and bone resorption [J]. Int J Mol Sci, 2020, 21(14).
[54]	Roy B, Curtis ME, Fears LS, et al. Molecular mechanisms of obesity-induced osteoporosis and muscle atrophy [J]. Front Physiol, 2016, 7: 439.
[55]	Lin H, Sohn J, Shen H, et al. Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing [J]. Biomaterials, 2019, 203: 96-110.
[56]	Tencerova M, Frost M, Figeac F, et al. Obesity-associated hypermetabolism and accelerated senescence of bone marrow stromal stem cells suggest a potential mechanism for bone fragility [J]. Cell Rep, 2019, 27(7): 2050-2062.
[57]	Bredella MA, Torriani M, Ghomi RH, et al. Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women [J]. Obesity (Silver Spring), 2011, 19(1): 49-53.
[58]	Schwartz AV, Sigurdsson S, Hue TF, et al. Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults [J]. J Clin Endocrinol Metab, 2013, 98(6): 2294-2300.
[59]	Sheu Y, Amati F, Schwartz AV, et al. Vertebral bone marrow fat, bone mineral density and diabetes: The Osteoporotic Fractures in Men (MrOS) study [J]. Bone, 2017, 97: 299-305.
[60]	Usategui-Martin R, Perez-Castrillon JL, Briongos-Figuero L, et al. Genetic variants in obesity-related genes and the risk of osteoporotic fracture. The Hortega Follow-up Study [J]. Front Biosci (Landmark Ed), 2022, 27(1): 32.
[61]	Zhang Q, Riddle RC, Yang Q, et al. The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage [J]. Proc Natl Acad Sci U S A, 2019, 116(36): 17980-17989.

Please choose a citation manager

Content to export