Correlation analysis of physical development indexes and salivary sex hormones in obese children

doi:10.3877/cma.j.issn.2095-9605.2022.01.006

Abstract

Abstract:

Objective

To investigate the correlation and clinical significance of physical development indicators and salivary sex hormones in obese children.

Methods

40 obese children (obesity group) and normal body mass index (BMI) children (normal group) who underwent physical examinations in our hospital from May 2018 to May 2021 were selected, and we recorded the height, weight, waist circumference, and waist circumference of all children, as well as developmental indicators such as hip circumference and abdominal skinfold thickness. Enzyme-linked immunoassay (ELISA) was used to determine the concentration of testosterone and estradiol in saliva samples of all children, and to analyze the correlation between various developmental indicators and testosterone and estradiol.

Results

Compared with the control group, the level of salivary testosterone in obese children is significantly lower, while the level of salivary estradiol is significantly higher (P<0.05). The salivary estradiol levels of female children in the obese group were significantly higher than those in the control group (P<0.05). Salivary testosterone levels of all children were significantly positively correlated with height (P<0.05), and significantly negatively correlated with BMI, waist-to-hip ratio, waist circumference and abdominal skinfold thickness (P<0.05); while male children's saliva estradiol levels was a significant negative correlation with height (P<0.05), and a significant positive correlation with BMI and abdominal skinfold thickness (P<0.05). The salivary estradiol level of female children has a significant negative correlation with height (P<0.05), a significant positive correlation with BMI and waist circumference (P<0.05), and no significant correlation with waist-to-hip ratio and abdominal skinfold thickness (P>0.05).

Conclusions

The secretion of testosterone in saliva of obese children decreased, while the secretion of estradiol in saliva increased obviously. The level of salivary hormones was closely related to the degree of obesity and physical development of obese children.

Key words: Obese children, Saliva, Sex hormones, Development, Estradiol

Yusheng Hu, Haihui Liu, Yuguo Qiu. Correlation analysis of physical development indexes and salivary sex hormones in obese children[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(01): 36-40.

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References 20

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项目	肥胖组（n=40）		对照组（n=40）
项目	男（n=22）	女（n=18）	男（n=21）	女（n=19）
年龄（岁）	11.52±0.57	11.56±0.63	11.49±0.72	11.50±0.65
身高（cm）	141.4±3.4*	140.2±2.6*	147.5±3.7	145.7±2.8
体重（kg）	49.4±2.8*	47.8±3.0*	46.1±2.6	44.4±2.9
腰围（cm）	87.2±3.8*	88.4±4.2*	66.8±3.5	65.1±3.2
臀围（cm）	96.1±3.9*	95.4±3.6*	81.5±3.2	80.3±3.5
腰臀比	0.91±0.05*	0.93±0.06*	0.82±0.05	0.81±0.07
腹部皮褶厚度（mm）	44.2±5.2*	45.1±6.1*	22.4±3.9	24.3±4.5
BMI（kg/m²）	24.7±0.45*	24.3±0.47*	21.2±0.64	20.9±0.59

项目	肥胖组（n=40）		对照组（n=40）
项目	男（n=22）	女（n=18）	男（n=21）	女（n=19）
年龄（岁）	11.52±0.57	11.56±0.63	11.49±0.72	11.50±0.65
身高（cm）	141.4±3.4*	140.2±2.6*	147.5±3.7	145.7±2.8
体重（kg）	49.4±2.8*	47.8±3.0*	46.1±2.6	44.4±2.9
腰围（cm）	87.2±3.8*	88.4±4.2*	66.8±3.5	65.1±3.2
臀围（cm）	96.1±3.9*	95.4±3.6*	81.5±3.2	80.3±3.5
腰臀比	0.91±0.05*	0.93±0.06*	0.82±0.05	0.81±0.07
腹部皮褶厚度（mm）	44.2±5.2*	45.1±6.1*	22.4±3.9	24.3±4.5
BMI（kg/m²）	24.7±0.45*	24.3±0.47*	21.2±0.64	20.9±0.59

组别	n	睾酮（noml/L）	雌二醇（pg/mL）
肥胖组	22	2.34±0.35	3.53±0.41
对照组	21	3.42±0.44	2.86±0.38
t值		8.929	5.551
P值		<0.001	<0.001

组别	n	睾酮（noml/L）	雌二醇（pg/mL）
肥胖组	22	2.34±0.35	3.53±0.41
对照组	21	3.42±0.44	2.86±0.38
t值		8.929	5.551
P值		<0.001	<0.001

组别	n	睾酮（noml/L）	雌二醇（pg/mL）
肥胖组	18	2.17±0.27	4.21±0.32
对照组	19	2.21±0.26	3.43±0.28
t值		0.459	7.902
P值		0.648	<0.001

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