Effect of low radiation dose mode on serum miR-133a and miR-208a expression and long-term prognosis in obese patients with coronary heart disease after PCI

doi:10.3877/cma.j.issn.2095-9605.2021.03.004

Abstract

Abstract:

Objective

To explore the effect of low radiation dose mode on serum miR-133a and miR-208a expression and long-term prognosis in obese patients with coronary heart disease after PCI.

Methods

Eighty-two patients with a clear diagnosis of coronary heart disease and undergoing PCI in Huazhou People's Hospital were randomly divided into a study group and a control group, with 41 patients in each group. All patients were treated with PCI, and the study group was treated with low-dose radiation mode, while the control group was treated with regular dose mode. The expression levels of hs-CRP, miR-133a and miR-208a in the serum of the two groups, the changes of cardiac function indexes before and after treatment, the short-term recovery and long-term prognosis after PCI were compared.

Results

Compared with the control group, the expression levels of hs-CRP, miR-133a, and miR-208a in the serum of the study group were significantly reduced (P<0.05), and the postoperative bedtime and hospital stay were significantly shortened (P<0.05); Compared with before surgery, the patients in the study group had significantly improved LVEF, LVESD, LVEDD and other cardiac function indicators at 3 months after PCI (P<0.05), and the angina score at 1 year after surgery (P<0.01). There was no statistically significant difference in the surgical success rate and the total incidence of major adverse vascular events during the 1-year follow-up period between the two groups (P>0.05).

Conclusions

The low radiation dose mode can ensure the clinical efficacy of PCI surgery for obese patients, reduce radiation damage, and help improve the prognosis of patients with coronary heart disease.

Key words: Low radiation dose mode, Coronary heart disease, Percutaneous coronary intervention, Prognosis, miRNA-133a, miR-208a

Hangyu He, Nating Lai, Mingyu Yang. Effect of low radiation dose mode on serum miR-133a and miR-208a expression and long-term prognosis in obese patients with coronary heart disease after PCI[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2021, 07(03): 159-164.

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References 13

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名称	引物序列
miR-133a	上游引物：5'-CGCCGGTTACTGAGACACATTC-3'
	下游引物：5'-TGCAGATCGAATATTCCAGCATAC-3'
miR-208a	上游引物：5'-GTCCTTCAAGCAGACCGATGT-3'
	下游引物：5'-CAGCACTCAGTCAACGTCTCA-3'
U6	上游引物：5'-ATTGGAACGATACAGAGAAGATT-3'
	下游引物：5'-GGAACGCTTCACGAATTTG-3'

名称	引物序列
miR-133a	上游引物：5'-CGCCGGTTACTGAGACACATTC-3'
	下游引物：5'-TGCAGATCGAATATTCCAGCATAC-3'
miR-208a	上游引物：5'-GTCCTTCAAGCAGACCGATGT-3'
	下游引物：5'-CAGCACTCAGTCAACGTCTCA-3'
U6	上游引物：5'-ATTGGAACGATACAGAGAAGATT-3'
	下游引物：5'-GGAACGCTTCACGAATTTG-3'

组别	例数（n）	hs-CRP（mg/L）	miR-133a	miR-208a
研究组	41	3.19±1.38	1.46±0.92	0.79±0.25
对照组	41	4.42±1.90	2.01±1.27	1.07±0.64
t值		3.354	2.246	2.609
P值		<0.01	<0.05	<0.05

组别	例数（n）	hs-CRP（mg/L）	miR-133a	miR-208a
研究组	41	3.19±1.38	1.46±0.92	0.79±0.25
对照组	41	4.42±1.90	2.01±1.27	1.07±0.64
t值		3.354	2.246	2.609
P值		<0.01	<0.05	<0.05

组别	例数（n）	LVEF（%）		LVESD（mm）		LVEDD（mm）
组别	例数（n）	手术前	3月后	手术前	3月后	手术前	3月后
研究组	41	48.25±9.83	65.04±11.67^*	40.33±9.66	36.09±7.03^*	59.52±9.41	50.36±8.12^*
对照组	41	48.74±6.90	64.30±11.71^*	40.79±8.56	36.86±8.96^*	59.61±9.94	51.06±7.49^*
t值		0.261	0.287	0.228	0.433	0.042	0.406
P值		>0.05	>0.05	>0.05	>0.05	>0.05	>0.05

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