To compare the analgesic effect of different analgesic methods on patients with morbid obesity after weight reduction operation.

72 morbidly obese patients undergoing laparoscopic bariatric surgery under general anesthesia in the First Affiliated Hospital of Jinan University from September 2018 to March 2019 were included. The patients were randomly divided into non-steroidal anti-inflammatory analgesia group (SN), opioid combined NSAIDS analgesia group (OAN) and opioid analgesia group (SO), with 24 persons in each group. Before the end of the operation, 80 mg of paracyclob sodium combined with 60 mg of dizoxine intravenously in the SN group, 80 mg of paracyclob sodium combined with 10-15 mg of dizoxine intravenously in the OAN group, and 10~15 mg of dizoxine intravenously in the SO group. The pain VAS score and PONV score of patients returning safely to the ward after surgery (T1), 6 h (T2), 12 h (T3) and 24 h (T4) were recorded. The occurrence of adverse reactions such as dizziness, chest tightness and pruritus were recorded, and the satisfaction degree of the patients with analgesia treatment 48 hours after the operation was recorded.

Compared with SO group, VAS scores of SN group and OAN group were significantly reduced at different time points (P<0.05). VAS scores at different time points of SN and OAN showed no statistical significance (P>0.05). Compared with SN group, PONV score of OAN group was significantly increased at the time of returning to the ward and 6h after operation (P<0.05). Compared with SN group, PONV score of SO group was significantly increased at T1 (P<0.05). There was no statistical significance in the three groups or in the satisfaction survey of adverse reactions and analgesia treatment (P>0.05).

Only using non-steroidal anti-inflammatory drugs after bariatric surgery in patients with morbid obesity has significant analgesic effect, and postoperative nausea and vomiting are mild, which may be an ideal analgesic option.