Correlation analysis of the relationship between the changes of pulmonary function and inflammatory mediators and adipokines in obese patients after LSG.

doi:10.3877/cma.j.issn.2095-9605.2020.04.002

Abstract

Abstract:

Objective

To explore the changes of pulmonary function in obese patients 6 months after treatment with laparoscopic sleeve gastrectomy (LSG), and to evaluate its correlation with adipokines and inflammatory factors.

Methods

A retrospective analysis was made on 116 obese patients who underwent LSG surgery in the second affiliated Hospital of Anhui Medical University from January 2019 to May 2020. The changes of body weight, BMI, pulmonary function, adipose factors and inflammatory mediators were compared before and 6 months after operation, and the correlation between the changes of pulmonary function and inflammatory mediators and adipose factors was further analyzed. A total of 116 obese patients undergoing LSG were included in this study, including 53 males and 63 females, with an average age of (32.52±6.08) years and BMI of (43.35±7.20) kg/m².

Results

Weight, BMI, neck circumference, waist circumference, and abdominal circumference were significantly lower at 6 months after surgery (P<0.05), and pulmonary function indexes such as FVC, FEV1, FEV1/FVC (%), and MMEF75/25 were significantly lower after surgery (P<0.05). The levels of leptin, TNF-a, IL-6, and CRP were significantly reduced at 6 months after surgery (P<0.05); IL -10 and adiponectin were significantly increased at 6 months after surgery (P<0.05). Before surgery, TNF-a, IL-6, CRP and Leptin were negatively correlated with FEV1, adiponectin was positively correlated with FVC, while TNF-a and leptin was negatively correlated with FVC; and at 6 months after surgery, IL-6 is negatively correlated with FEV1; adiponectin is significantly positively correlated with FVC; and TNF-a is negatively correlated with FVC.

Conclusions

LSG can significantly improve the lung function of obese patients. The improvement of lung function may be related to the changes of postoperative adipose factors and inflammatory mediators.

Key words: Obesity, Pulmonary function, Inflammatory mediators, Adipokines, Laparoscopic sleeve gastrectomy

Yanwei Liu, Yanyan Xu, Yong Wang. Correlation analysis of the relationship between the changes of pulmonary function and inflammatory mediators and adipokines in obese patients after LSG.[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2020, 06(04): 218-222.

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References 19

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变量	术前	术后6月	t值	P值
性别			/	/
男（人）	53	53
女（人）	63	63
年龄（岁）	32.52±6.08	32.52±6.08	/	/
体重（kg）	117.40±14.79	90.88±6.85	17.524	<0.001*
BMI（kg/m²）	43.35±7.20	28.13±4.15	19.724	<0.001*
颈围（cm）	125.46±15.7	102.27±6.95	14.538	<0.001*
腹围（cm）	130.59±10.13	118.53±11.06	8.660	<0.001*
腰围（cm）	128.94±11.61	114.96±14.11	8.237	<0.001*
肺功能指标
FVC	3.05±0.46	3.48±0.45	-7.216	<0.001*
FEV1	2.58±0.39	3.27±0.58	-10.585	<0.001*
FEV1/FVC（%）	80.54±6.00	85.38±4.21	-7.115	<0.001*
PEF（L/S）	5.23±1.12	5.17±1.01	-6.850	0.707
MMEF75/25	2.90±0.32	3.39±0.71	0.376	<0.001*

变量	术前	术后6月	t值	P值
性别			/	/
男（人）	53	53
女（人）	63	63
年龄（岁）	32.52±6.08	32.52±6.08	/	/
体重（kg）	117.40±14.79	90.88±6.85	17.524	<0.001*
BMI（kg/m²）	43.35±7.20	28.13±4.15	19.724	<0.001*
颈围（cm）	125.46±15.7	102.27±6.95	14.538	<0.001*
腹围（cm）	130.59±10.13	118.53±11.06	8.660	<0.001*
腰围（cm）	128.94±11.61	114.96±14.11	8.237	<0.001*
肺功能指标
FVC	3.05±0.46	3.48±0.45	-7.216	<0.001*
FEV1	2.58±0.39	3.27±0.58	-10.585	<0.001*
FEV1/FVC（%）	80.54±6.00	85.38±4.21	-7.115	<0.001*
PEF（L/S）	5.23±1.12	5.17±1.01	-6.850	0.707
MMEF75/25	2.90±0.32	3.39±0.71	0.376	<0.001*

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