Relationship between serum Omentin-1 expression and obesity and insulin resistance in children

doi:10.3877/cma.j.issn.2095-9605.2020.01.007

Abstract

Abstract:

Objective

To explore the relationship between the expression level of Omentin-1 in children and obesity and insulin resistance.

Methods

A total of 86 children who underwent physical examination Maternal and Child Health Hospital of Yangchun, Guangdong from February 2018 to December 2019 were selected, including 43 obese and normal children each. The serum Omentin-1 expression levels of all children were detected and analyzed. The waist-hip ratio, muscle mass, fat-free weight, body fat percentage, visceral fat area and basal metabolic rate, fasting blood glucose and insulin levels were detected and analyzed, and the relationship between serum Omentin-1 and body mass index and insulin resistance was analyzed.

Results

The serum Omentin-1 level in the obese group was significantly lower than that in the normal group, the difference was statistically significant (P<0.001). The waist-hip ratio, muscle mass, fat-free weight, body fat percentage, visceral fat area and basal metabolic rate in the obese group were significantly higher than those in the normal group (P<0.001). Serum Omentin-1 level was significantly negatively correlated with waist-hip ratio, body fat percentage, visceral fat area, fasting insulin and HOMA-IR (P<0.001).

Conclusions

Compared with normal weight children, serum Omentin-1 is significantly lower in obese children. Serum Omentin-1 levels are significantly negatively correlated with waist-hip ratio, body fat percentage, visceral fat area, fasting insulin and HOMA-IR.

Key words: Omentin-1, Children, Obesity, Insulin resistance, Relationship

Qiongke Ke, Ying Qiu, Xiaodan Gan, Yinghui Lin. Relationship between serum Omentin-1 expression and obesity and insulin resistance in children[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2020, 06(01): 33-36.

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References 15

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组别	N（例）	年龄（岁）	性别（男/女）	BMI（kg/m²）
正常组	43	10.2±1.51	24/19	17.52±1.40
肥胖组	43	9.8±1.70	22/21	22.71±1.92
t/χ²值	?	1.157	0.187	14.448
P值	?	0.251	0.665	<0.001

组别	N（例）	年龄（岁）	性别（男/女）	BMI（kg/m²）
正常组	43	10.2±1.51	24/19	17.52±1.40
肥胖组	43	9.8±1.70	22/21	22.71±1.92
t/χ²值	?	1.157	0.187	14.448
P值	?	0.251	0.665	<0.001

组别	n（例）	Omentin-1（ng/ml）	腰臀比	肌肉量（kg）	去脂体重（kg）	体脂百分比（%）	内脏脂肪面积（cm³）	基础代谢率（kcal）
正常组	43	309.2±57.3	0.69±0.05	27.12±2.43	29.12±2.55	28.08±3.41	46.15±8.42	984.21±87.32
肥胖组	43	228.6±47.2	0.81±0.09	30.67±3.04	33.08±3.32	35.27±3.16	89.28±16.41	1083.22±89.36
t值	?	7.119	7.643	5.981	6.203	10.141	11.119	5.197
P值	?	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别	n（例）	Omentin-1（ng/ml）	腰臀比	肌肉量（kg）	去脂体重（kg）	体脂百分比（%）	内脏脂肪面积（cm³）	基础代谢率（kcal）
正常组	43	309.2±57.3	0.69±0.05	27.12±2.43	29.12±2.55	28.08±3.41	46.15±8.42	984.21±87.32
肥胖组	43	228.6±47.2	0.81±0.09	30.67±3.04	33.08±3.32	35.27±3.16	89.28±16.41	1083.22±89.36
t值	?	7.119	7.643	5.981	6.203	10.141	11.119	5.197
P值	?	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别	n（例）	空腹血糖（mmol/L）	空腹胰岛素（mIU/L）	HOMA-IR
正常组	43	5.02±0.81	5.62±1.36	1.25±0.23
肥胖组	43	4.98±0.59	14.31±2.24	3.16±0.69
t值	?	0.262	21.745	17.220
P值	?	0.794	<0.001	<0.001

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