Influence of bariatric surgery on subclinical hypothyroidism in obese patients: a Meta-analysis

doi:10.3877/cma.j.issn.2095-9605.2019.02.005

Abstract

Abstract:

Objective

To conduct a meta-analysis regarding the impact of bariatric surgery on obesity-related subclinical hypothyroidism (SH).

Methods

A literature search was conducted on the databases which included the PubMed, Embase, Cochrane library, Wanfang and CNKI about the effect of bariatric surgery on obesity with SH. The retrieval time was from inception to April 2019. The quality of the included trials was assessed by methodological index for non-randomized studies (MINORS). Meta analysis was performed using RevMan 5.3.

Results

Five articles were included into meta-analysis, which indicated that bariatric surgery was associated with a reduction in TSH (SMD =1.94, 95%CI: 1.59~2.30, P<0.00001), but no change in FT4 (SMD=0.15, 95%CI: -0.77~1.08, P=0.74). In addition, bariatric surgery was expected to benefit obese patients with SH (OR=49.75, 95%CI: 15.08~164.15, P<0.00001).

Conclusions

The significant improvement of SH in obese patients can be an additional benefit of bariatric surgery.

Key words: Bariatric surgery, Subclinical hypothyroidism, Obesity, Meta-analysis

Wen Zeng, Peicai Qiu, Zhiguang Gao. Influence of bariatric surgery on subclinical hypothyroidism in obese patients: a Meta-analysis[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2019, 05(02): 90-95.

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References 22

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作者	年份	国家	文献类型	手术方式	总人数	SH人数	年龄（年）	随访时间（月）	结局指标
2014 Ruiz-Tovar^[3]	2014年	西班牙	回顾性分析	SG	60	10	43.3±10.4	12	SH改变
2005 Moulin^[6]	2005年	巴西	前瞻性研究	RYGB	72	18	40.3±10.5	12	TSH, FT4, T3
2015 Janssen^[7]	2015年	荷兰	回顾性分析	RYGB	503	61	42±13	12	TSH, FT4, SH改变
2007 Chikunguwo^[8]	2007年	美国	回顾性分析	RYGB/AGB	86	9	33-68	12	SH改变
2017杨^[9]	2017年	中国	回顾性分析	SG	69	14	29.4±6.8	12	TSH, SH改变
Total	?	?	?	?	790	112	?	?	?

作者	年份	国家	文献类型	手术方式	总人数	SH人数	年龄（年）	随访时间（月）	结局指标
2014 Ruiz-Tovar^[3]	2014年	西班牙	回顾性分析	SG	60	10	43.3±10.4	12	SH改变
2005 Moulin^[6]	2005年	巴西	前瞻性研究	RYGB	72	18	40.3±10.5	12	TSH, FT4, T3
2015 Janssen^[7]	2015年	荷兰	回顾性分析	RYGB	503	61	42±13	12	TSH, FT4, SH改变
2007 Chikunguwo^[8]	2007年	美国	回顾性分析	RYGB/AGB	86	9	33-68	12	SH改变
2017杨^[9]	2017年	中国	回顾性分析	SG	69	14	29.4±6.8	12	TSH, SH改变
Total	?	?	?	?	790	112	?	?	?

作者	手术前				手术后
作者	SH人数	TSH	FT4	T3	SH人数	TSH	FT4	T3
Ruiz-Tovar^[3]	10	-	-	-	1	-	-	-
Moulin^[6]	18	5.27 ± 1.22	1.04± 0.13	129.1 ± 22.1	-	2.68 ± 0.89	1.09 ± 0.14	104.3 ± 16.7
Janssen^[7]	61	5.82 ± 2.05	15.2 ± 2.1	-	8	2.78 ± 1.31	13.9 ± 2.3	-
Chikunguwo^[8]	9	-	-	-	0	-	-	-
杨^[9]	14	6.07 ± 1.68	-	-	0	2.88 ±0.56	-	-
Total	112	?	?	?	9	?	?	?

作者	手术前				手术后
作者	SH人数	TSH	FT4	T3	SH人数	TSH	FT4	T3
Ruiz-Tovar^[3]	10	-	-	-	1	-	-	-
Moulin^[6]	18	5.27 ± 1.22	1.04± 0.13	129.1 ± 22.1	-	2.68 ± 0.89	1.09 ± 0.14	104.3 ± 16.7
Janssen^[7]	61	5.82 ± 2.05	15.2 ± 2.1	-	8	2.78 ± 1.31	13.9 ± 2.3	-
Chikunguwo^[8]	9	-	-	-	0	-	-	-
杨^[9]	14	6.07 ± 1.68	-	-	0	2.88 ±0.56	-	-
Total	112	?	?	?	9	?	?	?

文献	明确的研究目的	患者纳入的连贯性	预期数据的收集	终点指标能否反映研究目的	终点指标评价的客观性	随访时间是否充足	失访率低于5%	总分
Ruiz-Tovar等^[3]	2	2	2	2	2	2	2	14
Moulin等^[6]	2	2	2	2	2	2	1	13
Janssen等^[7]	2	2	2	2	2	2	1	13
Chikunguwo等^[8]	2	2	2	2	2	2	2	14
杨等^[9]	2	2	2	2	2	2	2	14

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