Clinical study for compostion of urinary calculi and metabolic abnormality

doi:10.3877/cma.j.issn.2095-9605.2018.01.008

Abstract

Abstract:

Objective

To explore the relationship between calculus composition and metabolic abnormality in patients with urinary calculi.

Methods

200 cases of urinary calculi were collected with samples of calculi, serum and urine samples, the composition of calculus and blood /urine metabolism were measured.

Results

86 (43%) of the patients were analyzed with calculus of calcium oxalate. Metabolic abnormalities were found in 90.5% of the patients, most frequently with hyperoxalic acid (64.5%), followed by hypercalciuria, hypercalcemia, hypocitric acid and hyperuricemia. High oxalic acid urine induced calcium oxalate stone, the mixed composition stone of calcium oxalate/calcium phosphate and calcium oxalate/uric acid ;low citric acid urine induced calcium oxalate and calcium phosphate stones; Hypernatremia and hyperuricemia are all induce calcium oxalate calculi; Homocysteine only induced cysteine calculi.

Conclusions

Metabolic abnormalities are common in patients with urinary calculus, most of which are high oxalate, hypercalciuria, hypercalcemia, low citrate, hyperuricemia. Metabolic abnormalities can induce calculi, calculus composition and metabolic analysis can help to choose appropriate medical treatment and adjust dietary habits which can prevent the recurrence of stones.

Key words: Urinary, Calculus composition, Metabolic abnormality

Wei Du, Dong Li, Xiaosong Song, Zhaoying Fan, Qiangguo Yu. Clinical study for compostion of urinary calculi and metabolic abnormality[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2018, 04(01): 35-39.

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References 19

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岁数	男性		女性		总计
岁数	病人数	百分比（%）	病人数	百分比（%）	病人数	百分比（%）
10~20	15	7.5	8	4	23	11.5
21~30	22	11	13	6.5	35	17.5
31~40	52	26	27	13.5	79	39.5
41~50	46	23	17	8.5	63	31.5
总计	135	67.5	65	32.5	200	100

岁数	男性		女性		总计
岁数	病人数	百分比（%）	病人数	百分比（%）	病人数	百分比（%）
10~20	15	7.5	8	4	23	11.5
21~30	22	11	13	6.5	35	17.5
31~40	52	26	27	13.5	79	39.5
41~50	46	23	17	8.5	63	31.5
总计	135	67.5	65	32.5	200	100

参数	病人数（例）	百分比（%）
草酸钙	86	43
草酸钙+磷酸钙	50	25
草酸钙+尿酸	40	20
磷酸钙	5	2.5
尿酸	10	5
磷酸铵镁	5	2.5
胱氨酸	4	2

参数	病人数（例）	百分比（%）
草酸钙	86	43
草酸钙+磷酸钙	50	25
草酸钙+尿酸	40	20
磷酸钙	5	2.5
尿酸	10	5
磷酸铵镁	5	2.5
胱氨酸	4	2

代谢异常	病人数（例）	百分比（%）
高草酸尿症	129	64.5
高钙尿症	87	43.5
低枸橼酸尿症	81	40.5
高钠血症	59	29.5
高尿酸尿症	43	21.5
低镁血症	27	13.5
高磷血症	23	11.5
高钙血症	93	46.5
高尿酸血症	59	29.5

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