Influence of the changes of serum copper and zinc ions on the attack of bipolar disorder

doi:10.3877/cma.j.issn.2095-9605.2016.04.009

Abstract

Abstract:

Objective

To explore the influence of changes of serum copper and zinc ions on the attack of bipolar disorder.

Methods

Clinical data of 64 bipolar disorder patients being diagnosed and treated and 30 healthy volunteers in the First Affiliated Hospital of Jinan University from August 2013 to February 2015 were retrospectively analyzed. Among the 94 subjects, 43 were males and 51 were females with an average age of (28±10) years old. The informed consents were obtained from all of the subjects and the local ethical committee approval had been received. According to the mood states, all the subjects were divided into 3 groups: 32 patients in the acute episode of bipolar disorder, 32 patients in the remission episode of bipolar disorder and 30 subjects in the control group. Copper ion, zinc ion and ceruloplasmin were tested by collecting every subject’s venous blood in fasting state in the morning. The comparisons of clinical and experimental data among the 3 groups were conducted using ANOVA analysis, with LSD-t test for pairwise comparison; and comparisons between two sexes were conducted using χ² test.

Results

The concentrations of copper ion and ceruloplasmin and copper/zinc ratio of the patients in acute episode of bipolar disorder were significantly lower than those of the control group (LSD-t=–2.32, –0.11, –0.74, P<0.05), but the concentration of zinc ion was higher than that of the control group (LSD-t=3.28, P<0.05). The concentrations of copper and ceruloplasmin and copper/zinc ratio of the patients in remission episode of bipolar disorder were higher than those of patients in acute episode (LSD-t=–3.94, –0.05, –0.79, P<0.05), but the concentration of zinc ion was lower than that of patients in acute episode (LSD-t=2.51, P<0.05). The concentration of ceruloplasmin of the patients in remission episode of bipolar disorder was lower than that of the control group (LSD-t=–0.06, P<0.05), but the concentrations of copper and zinc ions and copper/zinc ratio had no statistical difference with those of the control group (P>0.05).

Conclusions

The patients with bipolar disorder can encounter abnormal concentrations of copper and zinc in both acute and remission episodes. The concentration changes of copper and zinc ions may become one of the characteristic performances to monitor trace element for bipolar disorder; however, the changing mechanism remains to be investigated.

Key words: Bipolar disorder, Trace element, Copper, Zinc

Shunkai Lai, Shuming Zhong, Hui Zhao, Zhinan Li, Yanbin Jia. Influence of the changes of serum copper and zinc ions on the attack of bipolar disorder[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2016, 02(04): 225-229.

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References 20

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组别	例数	性别（例）		年龄（岁，±s）
组别	例数	男	女	年龄（岁，±s）
双相障碍抑郁期组	32	17	15	25±8
双相障碍缓解期组	32	11	21	29±11
正常对照组	30	15	15	30±10
统计值	?	χ²=0.681		F=2.092
P值	?	>0.05		>0.05

组别	例数	性别（例）		年龄（岁，±s）
组别	例数	男	女	年龄（岁，±s）
双相障碍抑郁期组	32	17	15	25±8
双相障碍缓解期组	32	11	21	29±11
正常对照组	30	15	15	30±10
统计值	?	χ²=0.681		F=2.092
P值	?	>0.05		>0.05

组别	例数	铜离子（μmol/L）	铜蓝蛋白（μmol/L）	锌离子（μmol/L）	铜/锌比值
双相障碍抑郁期组	32	14.0±4.1^a，b	0.34±0.07^a，b	12.6±2.1^a，b	1.1±0.5^a，b
双相障碍缓解期组	32	17.9±5.2	0.39±0.11^c	10.1±2.8	1.9±1.0
正常对照组	30	16.3±2.5	0.46±0.07	9.3±2.5	1.9±0.6
F值	?	7.50	14.24	15.19	11.51
P值	?	<0.05	<0.05	<0.05	<0.05

组别	例数	铜离子（μmol/L）	铜蓝蛋白（μmol/L）	锌离子（μmol/L）	铜/锌比值
双相障碍抑郁期组	32	14.0±4.1^a，b	0.34±0.07^a，b	12.6±2.1^a，b	1.1±0.5^a，b
双相障碍缓解期组	32	17.9±5.2	0.39±0.11^c	10.1±2.8	1.9±1.0
正常对照组	30	16.3±2.5	0.46±0.07	9.3±2.5	1.9±0.6
F值	?	7.50	14.24	15.19	11.51
P值	?	<0.05	<0.05	<0.05	<0.05

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