The analysis of changing about serum adiponectin in obese patients with type 2 diabetes after laparoscopic gastric bypass

doi:10.3877/cma.j.issn.2095-9605.2015.01.009

Abstract

Abstract:

Objective

To investigate the changing of serum adiponectin in obese patients with T2DM who underwent laparoscopic Roux-en-Y gastric bypass (LRYGB).

Methods

From March 2011 to February 2012,52 obese patients with T2DM were admitted to Armed Police General Hospital and underwent LRYGB. The follow-up time is one year. Adiponectin, HbA1c, triglycerides, cholesterol, OGTT and insulin release test were detected in postoperative time of 1 week and 1, 3, 6, 12 months.

Results

The follow-up rate is 100% with no loss; During the one-year follow-up, the cure rate of T2DM was 86.5% (45/52) and the cure rate of obesity was 67.3% (35/52); Comparing with the mean level of 4.3 ug/ml of adiponectin pre-operatively, adiponectin decreased to 2.93 ug/ml slightly within 3 months follow-up, then increased gradually to 7.36 ug/ml, the level of 12 months after procedures had a statistical difference comparing to the preoperative level (P＜0.05); the levels of FPG, HbA1c and HOMA-IR decreased continuously, and had statistical differences comparing to the preoperative levels (P＜0.05).

Conclusions

LRYGB has exact treating effectiveness for obese patients with T2DM,and the increased level of adiponectin after procedures may be related to the mechanism of improvement of glucose metabolism.

Key words: Laparoscopic Roux-en-Y gastric bypass, Diabetes mellitus, Type 2, Obesity, Adiponectin

Hui Han, Guoju Fan, Hongkai Gao, Xiaoli Yang, Jing Guo, Deyong Zou, Liping Zhang, Ye Zhang. The analysis of changing about serum adiponectin in obese patients with type 2 diabetes after laparoscopic gastric bypass[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2015, 01(01): 34-38.

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References 13

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观察时间	体重（kg）	BMI（kg/m²）	HbA1c（%）	FPG（mmol/L）	2hPG（mmol/L）	FIns（pmol/L）
术前	88±13	31.8±2.3	8.0±1.5	10.0±3.5	18.6±4.8	24.8±9.8
术后1周	86±14	30.1±4.4	7.2±1.4	7.3±1.7	16.1±4.8	18.6±6.9
术后1个月	84±12	28.4±3.3	6.7±0.9	7.8±1.9	14.3±5.0	15.9±5.9
术后3个月	79±13	27.4±3.5	6.7±1.0	7.6±2.3	11.4±4.4	12.7±4.5
术后6个月	64±7	23.8±1.1	7.1±1.4	6.1±0.8	10.2±2.8	10.1±2.7
术后12个月	72±11*	24.3±1.9*	6.5±0.9*	6.5±0.5*	10.5±3.2*	6.9±2.0*
观察时间	FCp（μg/L）	HOMA-IR	FAPN（mg/L）	2hAPN（mg/L）	TG（mmol/L）	CH（mmol/L）
术前	2.9±0.9	10.3±5.0	4.4±2.2	3.2±2.0	3.5±1.5	5.1±1.2
术后1周	2.0±0.8	9.5±7.3	3.1±1.3	3.0±1.4	3.2±1.2	5.0±1.0
术后1个月	2.8±0.9	8.6±5.6	3.2±1.7	2.7±1.1	2.7±1.1	4.5±1.0
术后3个月	2.7±0.9	6.7±7.3	2.9±1.4	3.7±2.3	1.7±0.4	4.0±1.2
术后6个月	2.1±0.5	2.1±2.7	5.4±2.4	2.7±0.9	1.7±0.7	3.7±0.9
术后12个月	2.3±0.9	2.6±1.0*	7.4±3.7*	6.9±2.7*	1.1±0.4*	4.0±0.5*

观察时间	体重（kg）	BMI（kg/m²）	HbA1c（%）	FPG（mmol/L）	2hPG（mmol/L）	FIns（pmol/L）
术前	88±13	31.8±2.3	8.0±1.5	10.0±3.5	18.6±4.8	24.8±9.8
术后1周	86±14	30.1±4.4	7.2±1.4	7.3±1.7	16.1±4.8	18.6±6.9
术后1个月	84±12	28.4±3.3	6.7±0.9	7.8±1.9	14.3±5.0	15.9±5.9
术后3个月	79±13	27.4±3.5	6.7±1.0	7.6±2.3	11.4±4.4	12.7±4.5
术后6个月	64±7	23.8±1.1	7.1±1.4	6.1±0.8	10.2±2.8	10.1±2.7
术后12个月	72±11*	24.3±1.9*	6.5±0.9*	6.5±0.5*	10.5±3.2*	6.9±2.0*
观察时间	FCp（μg/L）	HOMA-IR	FAPN（mg/L）	2hAPN（mg/L）	TG（mmol/L）	CH（mmol/L）
术前	2.9±0.9	10.3±5.0	4.4±2.2	3.2±2.0	3.5±1.5	5.1±1.2
术后1周	2.0±0.8	9.5±7.3	3.1±1.3	3.0±1.4	3.2±1.2	5.0±1.0
术后1个月	2.8±0.9	8.6±5.6	3.2±1.7	2.7±1.1	2.7±1.1	4.5±1.0
术后3个月	2.7±0.9	6.7±7.3	2.9±1.4	3.7±2.3	1.7±0.4	4.0±1.2
术后6个月	2.1±0.5	2.1±2.7	5.4±2.4	2.7±0.9	1.7±0.7	3.7±0.9
术后12个月	2.3±0.9	2.6±1.0*	7.4±3.7*	6.9±2.7*	1.1±0.4*	4.0±0.5*

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