随着动脉粥样硬化性心血管疾病日益成为全球主要死亡和致残原因，泛血管疾病已成为一个亟待解决的重大公共卫生问题。系统性防治和针对性干预是泛血管疾病诊疗理念的重点。体重变异性升高是泛血管疾病发生风险和全因死亡的一个重要独立危险因素。体重变异性升高增加心、脑血管事件、糖尿病性血管病变等不良血管事件的发生和发展，并预测患者不良预后。在以患者为中心的综合健康管理中，关注体重健康的同时，还需关注体重控制的长期稳定性，对于进一步降低泛血管疾病的发生、发展有重要意义。

The pan-vascular disease has become a major public health problem that needs to be solved urgently, with the atherosclerotic cardiovascular disease has become a major cause of death and disability worldwide. Systematic prevention and treatment and targeted intervention are the key points in the diagnosis and treatment concept of pan-vascular diseases. High body weight variability is an important risk factor for the risk of pan-vascular disease and all-cause mortality and is independent of baseline weight levels. High body weight variability increases the occurrence and development of adverse vascular events such as cardiac and cerebrovascular events and type diabetic vascular disease, and predicts the poor prognosis of patients. In patient-centered comprehensive health management, it is important to pay attention to the long-term stability of weight control while paying attention to weight, which is of great significance to further reduce the occurrence and development of pan-vascular diseases.