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中华肥胖与代谢病电子杂志 ›› 2024, Vol. 10 ›› Issue (03) : 206 -212. doi: 10.3877/cma.j.issn.2095-9605.2024.03.008

综述

减重手术治疗肥胖症相关认知障碍的研究进展
高昊雯, 王桂琦, 庞利云, 张新昕, 谷敬锋()   
  1. 050000 石家庄,河北医科大学第一医院胃肠病诊疗一科(减重与代谢性疾病)
  • 收稿日期:2023-10-07 出版日期:2024-08-30
  • 通信作者: 谷敬锋

Research progress of bariatric surgery for the treatment of obesity-related cognitive impairment

Haowen Gao, Guiqi Wang, Liyun Pang, Xinxin Zhang, Jingfeng Gu()   

  1. Department of Gastroenterology (Weight Loss and Metabolic Diseases), The First Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2023-10-07 Published:2024-08-30
  • Corresponding author: Jingfeng Gu
引用本文:

高昊雯, 王桂琦, 庞利云, 张新昕, 谷敬锋. 减重手术治疗肥胖症相关认知障碍的研究进展[J]. 中华肥胖与代谢病电子杂志, 2024, 10(03): 206-212.

Haowen Gao, Guiqi Wang, Liyun Pang, Xinxin Zhang, Jingfeng Gu. Research progress of bariatric surgery for the treatment of obesity-related cognitive impairment[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(03): 206-212.

肥胖不仅增加高血压、2型糖尿病、心血管疾病等多种疾病的患病风险,也与认知功能障碍的发生密切相关。目前,减重手术已被证实为治疗肥胖的有效手段,其对认知功能的影响也备受关注。越来越多的研究显示减重手术对改善肥胖相关认知功能障碍具有积极作用。然而肥胖、减重手术与肥胖相关认知障碍之间的关系复杂,关联机制及改善情况尚未得到充分而准确的阐述。本文根据近年来的相关研究,阐述肥胖相关认知障碍的发生机制,描述现有治疗方法,综述减重手术改善肥胖相关认知障碍的研究进展,旨在为治疗肥胖相关认知障碍提供更多依据,为改善肥胖患者认知功能提供合适的治疗方案。

Obesity not only increases the risk of a variety of diseases such as hypertension, type 2 diabetes, and cardiovascular disease but is also strongly associated with the development of cognitive dysfunction. Currently, bariatric surgery has been proven to be an effective treatment for obesity, and its impact on cognitive function is of great concern. A growing body of research is showing the positive effects of bariatric surgery in improving obesity-related cognitive dysfunction. However, the relationship between obesity, bariatric surgery and cognitive impairment is complex and the mechanisms and improvements have not been fully and accurately described. Based on the relevant studies in recent years, this paper describes the occurrence mechanism of obesity-related cognitive impairment, describes the existing treatment methods, and reviews the research progress of bariatric surgery to improve obesity-related cognitive impairment, aiming to provide more bases for the treatment of obesity-related cognitive impairment, and provide more appropriate treatment programs to improve the cognitive function of patients with obesity.

图1 肥胖引起相关认知功能障碍的可能机制、减重手术改善肥胖相关认知障碍的可能机制及目前针对肥胖相关认知障碍的治疗方法
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