胃漏是腹腔镜袖状胃切除术（LSG）联合胃底折叠术后最主要及最严重的并发症。本文报道1例内镜负压治疗LSG联合胃底折叠术后发生胃漏的病例。患者术前诊断为代谢综合征合并胃食管反流病（GERD），行LSG联合胃底折叠术，术后第10天因胃漏再次入院，行折叠瓣及漏口切除术。术后第5天再次发生胃漏，行内镜下负压装置及鼻-空肠营养管置入，术后予以肠内肠外营养，治疗过程中多次腹腔脓肿穿刺引流。术后2个月复查上腹部CT及上消化道造影，提示治愈。本病例提示我们对于有GERD的肥胖患者，LSG联合胃底折叠术的安全性需要进一步评估。对于术后发生胃漏的患者，内镜负压治疗操作简单安全，值得临床借鉴。

Gastric leakage is the most critical and severe complication after laparoscopic sleeve gastrectomy (LSG) combined with fundoplication. We aimed to report a case treated with endoscopic negative pressure therapy for gastric leakage after LSG combined with fundoplication. The patient was diagnosed with metabolic syndrome and gastroesophageal reflux disease (GERD) before surgery. The patient underwent LSG combined with fundoplication. The patient was readmitted to the hospital due to gastric leakage on postoperative day 10 and underwent fundoplication flap resection and leakage site resection. The patient was complicated with gastric leakage on postoperative day 5. Endoscopic negative pressure therapy and a nasojejunal feeding tube were inserted and given enteral and parenteral nutrition. Multiple abdominal punctures and drainage were performed during the whole treatment process. CT of the upper abdomen and gastric radiography identified a cure for the leakage 2 months after surgery. For obese patients with GERD, the safety of LSG combined with fundoplication needs to be further evaluated. For patients with postoperative gastric leakage, endoscopic negative pressure therapy is effective and safe, which is worthy of clinical reference.