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中华肥胖与代谢病电子杂志 ›› 2024, Vol. 10 ›› Issue (01) : 58 -65. doi: 10.3877/cma.j.issn.2095-9605.2024.01.009

综述

肥胖对肺功能影响的研究进展
周泽恺1, 刘宝胤2, 聂云韬2,(), 孟化2,()   
  1. 1. 100038 北京,首都医科大学第八临床医学院
    2. 100029 北京,中日友好医院普外科·代谢减重中心
  • 收稿日期:2024-01-05 出版日期:2024-02-29
  • 通信作者: 聂云韬, 孟化
  • 基金资助:
    中央高水平医院临床科研业务费资助(NO.ZRJY2023-QM15); 中日友好医院"菁英计划"人才培育工程资助(NO.ZRJY2023-QM15); 中日友好医院中央高水平医院临床科研业务费资助(2023-NHLHCRF-YYPP-TS-02,2023-NHLHCRF-YS-0103); 北京市研究型病房建设临床研究项目(2022-YJXBF-03-02); 中日友好医院人才引进项目(NO.2018-RC-1); 青海省"昆仑英才·高端创新创业人才"项目(202308210043)

Research progress in the effects of obesity on lung function

Zekai Zhou1, Baoyin Liu2, Yuntao Nie2,(), Hua Meng2,()   

  1. 1. The Eighth Clinical Medical College of Capital Medical University, 100038 Beijing
    2. Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2024-01-05 Published:2024-02-29
  • Corresponding author: Yuntao Nie, Hua Meng
引用本文:

周泽恺, 刘宝胤, 聂云韬, 孟化. 肥胖对肺功能影响的研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(01): 58-65.

Zekai Zhou, Baoyin Liu, Yuntao Nie, Hua Meng. Research progress in the effects of obesity on lung function[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(01): 58-65.

肥胖的患病率不断增加,作为多种呼吸系统疾病的危险因素,肥胖患者呼吸系统的结构发生了显著改变,肺功能多项指标异常。本文综述了肥胖对呼吸系统正常结构以及对肺功能常用参数的影响,并讨论了其病理生理学机制。

The prevalence of obesity is increasing. As a risk factor for a variety of respiratory diseases, the structure and physiology of the respiratory system in patients with obesity is significantly altered. This article focuses on the effects of adult obesity on the lung function, and discusses its pathophysiologic mechanisms.

[1]
Kivimäki M, Strandberg T, Pentti J, et al. Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study [J]. The Lancet Diabetes & Endocrinology, 2022, 10(4): 253-263.
[2]
Chen K, Shen Z, Gu W, et al. Prevalence of obesity and associated complications in China: A cross‐sectional, real‐world study in 15.8 million adults [J]. Diabetes, Obesity and Metabolism, 2023, 25(11): 3390-3399.
[3]
Machluf Y, Farkash R, Fink D, et al. Asthma severity and heterogeneity: Insights from prevalence trends and associated demographic variables and anthropometric indices among Israeli adolescents [J]. Journal of Asthma, 2018, 55(8): 826-836.
[4]
Gomez-Llorente M, Romero R, Chueca N, et al. Obesity and Asthma: A Missing Link[J]. International Journal of Molecular Sciences, 2017, 18(7): 1490.
[5]
刘斌, 梁彦超, 刘双柏, 等. 肥胖和支气管哮喘之间的因果关联:一项双向孟德尔随机化研究 [J]. 国际呼吸杂志, 2023, 43(12):1421-1427.
[6]
Li J, Zhu L, Wei Y, et al. Association between adiposity measures and COPD risk in Chinese adults [J]. European Respiratory Journal, 2020,55(4): 1901899.
[7]
Huang T, Lin BM, Markt SC, et al. Sex differences in the associations of obstructive sleep apnoea with epidemiological factors [J]. European Respiratory Journal, 2018, 51(3): 1702421.
[8]
Balachandran JS, Masa JF, Mokhlesi B. Obesity Hypoventilation Syndrome [J]. Sleep Medicine Clinics, 2014, 9(3): 341-347.
[9]
Hedenstierna G, Santesson J. Breathing mechanics, dead space and gas exchange in the extremely obese, breathing spontaneously and during anaesthesia with intermittent positive pressure ventilation [J]. Acta Anaesthesiologica Scandinavica, 1976, 20(3): 248-254.
[10]
Pelosi P, Croci M, Ravagnan I, et al. Total Respiratory System, Lung, and Chest Wall Mechanics in Sedated-Paralyzed Postoperative Morbidly Obese Patients [J]. Chest, 1996, 109(1): 144-151.
[11]
Pelosi P, Croci M, Ravagnan I, et al. The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia [J]. Anesthesia & Analgesia, 1998, 87(3): 654-660.
[12]
Farkas GA, Schlenker EH. Pulmonary ventilation and mechanics in morbidly obese Zucker rats. [J]. American Journal of Respiratory and Critical Care Medicine, 1994, 150(2): 356-362.
[13]
Inselman LS, Chander A, Spitzer AR. Diminished Lung Compliance and Elevated Surfactant Lipids and Proteins in Nutritionally Obese Young Rats [J]. Lung, 2004,182(2): 101-117.
[14]
Shanmugasundaram K, Bade G, Sampath M, et al. Effect of obesity on airway mechanics [J]. Indian Journal of Endocrinology and Metabolism, 2023, 27(2): 161.
[15]
Peters U, Subramanian M, Chapman DG, et al. BMI but not central obesity predisposes to airway closure during bronchoconstriction [J]. Respirology, 2019, 24(6): 543-550.
[16]
Dixon AE, Poynter ME, Garrow OJ, et al. Peripheral Airway Dysfunction in Obesity and Obese Asthma [J]. Chest, 2023, 163(4): 753-762.
[17]
Elliot JG, Donovan GM, Wang KCW, et al. Fatty airways: implications for obstructive disease [J]. European Respiratory Journal, 2019, 54(6): 1900857.
[18]
Bhatawadekar SA, Peters U, Walsh RR, et al. Central airway collapse is related to obesity independent of asthma phenotype [J]. Respirology, 2021, 26(4): 334-341.
[19]
De Soomer K, Vaerenberg H, Weyler J, et al. Effects of Weight Change and Weight Cycling on Lung Function in Overweight and Obese Adults [J]. Annals of the American Thoracic Society, 2024, 21(1): 47-55.
[20]
Hegewald MJ. Impact of obesity on pulmonary function: current understanding and knowledge gaps [J]. Current Opinion in Pulmonary Medicine, 2021, 27(2): 132-140.
[21]
Jones RL, Nzekwu MU. The Effects of Body Mass Index on Lung Volumes [J]. Chest, 2006, 130(3): 827-833.
[22]
Zeng X, Liu D, An Z, et al. Obesity parameters in relation to lung function levels in a large Chinese rural adult population [J]. Epidemiology and Health, 2021, 43: e2021047.
[23]
Forno E, Han Y, Mullen J, et al. Overweight, obesity, and lung function in children and adults—a meta-analysis [J]. The Journal of Allergy and Clinical Immunology: In Practice, 2018, 6(2): 570-581.
[24]
Marillier M, Bernard A, Reimao G, et al. Breathing at Extremes [J]. Chest, 2020, 158(4): 1576-1585.
[25]
McNeill JN, Lau ES, Zern EK, et al. Association of obesity-related inflammatory pathways with lung function and exercise capacity [J]. Respiratory Medicine, 2021, 183: 106434.
[26]
Park Y, Kim J, Kim YS, et al. Longitudinal association between adiposity changes and lung function deterioration [J]. Respiratory Research, 2023, 24(1).
[27]
Alqarni AA, Aldhahir AM, Alqahtani JS, et al. Spirometry profiles of overweight and obese individuals with unexplained dyspnea in Saudi Arabia [J]. Heliyon, 2024, 10(3): e24935.
[28]
Hou P, Pi Y, Jiao Z, et al. Association of Body Composition with Pulmonary Function in Ningxia: The China Northwest Cohort [J]. Diabetes Metab Syndr Obes, 2022, 15: 3243-3254.
[29]
Zhang R, Zhou J, Cai Y, et al. Non-linear association of anthropometric measurements and pulmonary function [J]. Scientific Reports, 2021, 11(1): 14596.
[30]
Wang Y, Li Z, Li F. Nonlinear relationship between visceral adiposity index and lung function: a population-based study [J]. Respiratory Research, 2021, 22(1):161.
[31]
Liu J, Xu H, Cupples LA, et al. The impact of obesity on lung function measurements and respiratory disease: A Mendelian randomization study [J]. Annals of Human Genetics, 2023, 87(4): 174-183.
[32]
Skaaby T, Taylor AE, Thuesen BH, et al. Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization [J]. Allergy, 2018, 73(1): 153-164.
[33]
Wielscher M, Amaral AFS, van der Plaat D, et al. Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment [J]. Genome Medicine, 2021, 13(1): 104.
[34]
Backman H, Blomberg A, Lundquist A, et al. Lung Function Trajectories and Associated Mortality among Adults with and without Airway Obstruction [J]. American Journal of Respiratory and Critical Care Medicine, 2023, 208(10): 1063-1074.
[35]
Zhang X, Gray AR, Hancox RJ. Distinct trajectories of lung function from childhood to mid-adulthood [J]. Thorax, 2024, 2023-220436.
[36]
Carsin A, Garcia-Aymerich J, Accordini S, et al. Spirometric patterns in young and middle-aged adults: a 20-year European study [J]. Thorax, 2024, 79(2): 153-162.
[37]
Dharmage SC, Bui DS, Walters EH, et al. Lifetime spirometry patterns of obstruction and restriction, and their risk factors and outcomes: a prospective cohort study [J]. The Lancet Respiratory Medicine, 2023, 11(3): 273-282.
[38]
Lee J, Park HK, Kwon M, et al. The effect of metabolic health and obesity on lung function: A cross sectional study of 114,143 participants from Kangbuk Samsung Health Study [J]. PLOS ONE, 2022, 17(4): e266885.
[39]
朱蕾, 陈荣昌. 成人肺功能诊断规范中国专家共识 [J]. 临床肺科杂志, 2022, 27(7): 973-981.
[40]
Holley AB, Carbone T, Holtzclaw AW, et al. Obesity-related Changes in Diffusing Capacity and Transfer Coefficient of the Lung for Carbon Monoxide and Resulting Patterns of Abnormality across Reference Equations [J]. Annals of the American Thoracic Society, 2023, 20(7): 969-975.
[41]
Enache I, Oswald-Mammosser M, Scarfone S, et al. Impact of Altered Alveolar Volume on the Diffusing Capacity of the Lung for Carbon Monoxide in Obesity [J]. Respiration, 2011, 81(3): 217-222.
[42]
Holley HS, Milic-Emili J, Becklake MR, et al. Regional Distribution of Pulmonary Ventilation and Perfusion in Obesity [J]. Journal of Clinical Investigation, 1967, 46(4): 475-481.
[43]
Rivas E, Arismendi E, Agustí A, et al. Ventilation/Perfusion Distribution Abnormalities In Morbidly Obese Subjects Before and After Bariatric Surgery [J]. Chest, 2015, 147(4): 1127-1134.
[44]
Shore SA. Obesity, airway hyperresponsiveness, and inflammation [J]. Journal of Applied Physiology, 2010, 108(3): 735-743.
[45]
Celedón JC, Palmer LJ, Litonjua AA, et al. Body Mass Index and Asthma in Adults in Families of Subjects with Asthma in Anqing, China [J]. American Journal of Respiratory and Critical Care Medicine, 2001, 164(10): 1835-1840.
[46]
Chinn S. Relation of bronchial responsiveness to body mass index in the ECRHS [J]. Thorax, 2002, 57(12): 1028-1033.
[47]
Kim M, Cho S, Jung J, et al. Association between obesity and lung function changes by sex and age in adults with asthma [J]. Journal of Asthma, 2022, 59(1): 59-69.
[48]
Behazin N, Jones SB, Cohen RI, et al. Respiratory restriction and elevated pleural and esophageal pressures in morbid obesity [J]. Journal of Applied Physiology, 2010, 108(1): 212-218.
[49]
Steier J, Lunt A, Hart N, et al. Observational study of the effect of obesity on lung volumes [J]. Thorax, 2014, 69(8): 752-759.
[50]
Lo Mauro A, Tringali G, Codecasa F, et al. Pulmonary and chest wall function in obese adults [J]. Scientific Reports, 2023, 13(1): 17753.
[51]
Molani Gol R, Rafraf M. Association between abdominal obesity and pulmonary function in apparently healthy adults: A systematic review [J]. Obesity Research & Clinical Practice, 2021, 15(5): 415-424.
[52]
Svartengren M, Cai G, Malinovschi A, et al. The impact of body mass index, central obesity and physical activity on lung function: results of the EpiHealth study [J]. ERJ Open Research, 2020, 6(4): 214-2020.
[53]
Buras ED, Converso-Baran K, Davis CS, et al. Fibro-Adipogenic Remodeling of the Diaphragm in Obesity-Associated Respiratory Dysfunction [J]. Diabetes, 2019, 68(1): 45-56.
[54]
Yu X, Huang Y, Feng Y, et al. Association of Muscle Fat Content and Muscle Mass With Impaired Lung Function in Young Adults With Obesity: Evaluation With MRI [J]. Academic Radiology, 2024, 31(1): 9-18.
[55]
Park HK, Lee SH, Lee SY, et al. Relationships between lung function decline and skeletal muscle and fat mass changes: a longitudinal study in healthy individuals [J]. Journal of Cachexia, Sarcopenia and Muscle, 2021, 12(6): 2145-2153.
[56]
龚凤英, 胡雯婧. 脂肪组织:一个具有高度异质性和可塑性的内分泌和免疫器官 [J]. 中华糖尿病杂志, 2022, 14(12): 1469-1474.
[57]
Peters MC, Schiebler ML, Cardet JC, et al. The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma [J]. American Journal of Respiratory and Critical Care Medicine, 2022, 206(9): 1096-1106.
[58]
Scott HA, Ng SH, McLoughlin RF, et al. Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis [J]. Thorax, 2023, 78(10): 957-965.
[59]
Baltieri L, Cazzo E, Oliveira Modena DA, et al. Correlation between levels of adipokines and inflammatory mediators with spirometric parameters in individuals with obesity and symptoms of asthma: Cross-sectional study [J]. Pulmonology, 2022, 28(2): 105-112.
[60]
Palma G, Sorice GP, Genchi VA, et al. Adipose Tissue Inflammation and Pulmonary Dysfunction in Obesity [J]. International Journal of Molecular Sciences, 2022, 23(13): 7349.
[61]
Umetsu DT. Mechanisms by which obesity impacts upon asthma [J]. Thorax, 2017, 72(2): 174-177.
[62]
Park YH, Oh EY, Han H, et al. Insulin resistance mediates high-fat diet-induced pulmonary fibrosis and airway hyperresponsiveness through the TGF-β1 pathway [J]. Experimental & Molecular Medicine, 2019, 51(5): 1-12.
[63]
Han H, Chung SI, Park HJ, et al. Obesity-induced Vitamin D Deficiency Contributes to Lung Fibrosis and Airway Hyperresponsiveness [J]. American Journal of Respiratory Cell and Molecular Biology, 2021, 64(3): 357-367.
[64]
Mair KM, Harvey KY, Henry AD, et al. Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension [J]. European Respiratory Journal, 2019, 53(6): 1801524
[65]
Pu S, Yin L, Wen B, et al. The Association of Body Mass Index With the Risk of Pulmonary Hypertension in Adults: A Systematic Review and Meta-Analysis of Observational Studies [J]. Frontiers in Medicine, 2022, 8: 680223.
[66]
Frank RC, Min J, Abdelghany M, et al. Obesity Is Associated With Pulmonary Hypertension and Modifies Outcomes [J]. Journal of the American Heart Association, 2020, 9(5): e014195.
[67]
Reddy YNV, Anantha-Narayanan M, Obokata M, et al. Hemodynamic Effects of Weight Loss in Obesity [J]. JACC: Heart Failure, 2019, 7(8): 678-687.
[68]
Naeije R, Richter MJ, Rubin LJ. The physiological basis of pulmonary arterial hypertension [J]. European Respiratory Journal, 2022, 59(6): 2102334.
[69]
Thayer TE, Levinson RT, Huang S, et al. BMI Is Causally Associated With Pulmonary Artery Pressure But Not Hemodynamic Evidence of Pulmonary Vascular Remodeling [J]. Chest, 2021, 159(1): 302-310.
[70]
Low AT, Medford ARL, Millar AB, et al. Lung function in pulmonary hypertension [J]. Respiratory Medicine, 2015, 109(10): 1244-1249.
[71]
Shrine N, Guyatt AL, Erzurumluoglu AM, et al. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries [J]. Nature Genetics, 2019, 51(3): 481-493.
[72]
Zhao X, Qiao D, Yang C, et al. Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants [J]. Nature Communications, 2020, 11(1): 5182.
[73]
Zhu Z, Li J, Si J, et al. A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity [J]. European Respiratory Journal, 2021, 58(4): 2100199.
[74]
Peralta GP, Marcon A, Carsin A, et al. Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study [J]. Thorax, 2020, 75(4): 313-320.
[75]
Copley SJ, Jones LC, Soneji ND, et al. Lung parenchymal and tracheal ct morphology: evaluation before and after bariatric surgery [J]. Radiology, 2020, 294(3): 669-675.
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