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中华肥胖与代谢病电子杂志 ›› 2020, Vol. 06 ›› Issue (01) : 33 -36. doi: 10.3877/cma.j.issn.2095-9605.2020.01.007

所属专题: 文献

论著

儿童血清Omentin-1表达水平与肥胖及胰岛素抵抗的关系研究
柯琼可1,(), 邱莹1, 甘晓丹1, 林英慧1   
  1. 1. 529600 阳春,广东省阳春市妇幼保健院
  • 收稿日期:2020-01-05 出版日期:2020-02-28
  • 通信作者: 柯琼可

Relationship between serum Omentin-1 expression and obesity and insulin resistance in children

Qiongke Ke1,(), Ying Qiu1, Xiaodan Gan1, Yinghui Lin1   

  1. 1. Maternal and Child Health Hospital of Yangchun, Guangdong, Yangchun 529600, China
  • Received:2020-01-05 Published:2020-02-28
  • Corresponding author: Qiongke Ke
  • About author:
    Corresponding author: Ke Qiongke, Email:
引用本文:

柯琼可, 邱莹, 甘晓丹, 林英慧. 儿童血清Omentin-1表达水平与肥胖及胰岛素抵抗的关系研究[J/OL]. 中华肥胖与代谢病电子杂志, 2020, 06(01): 33-36.

Qiongke Ke, Ying Qiu, Xiaodan Gan, Yinghui Lin. Relationship between serum Omentin-1 expression and obesity and insulin resistance in children[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2020, 06(01): 33-36.

目的

探讨儿童血清网膜素-1(Omentin-1)表达水平与肥胖及胰岛素抵抗的关系。

方法

回顾性分析2018年2月至2019年12月于广东省阳春市妇幼保健院进行体检儿童共86例临床资料,其中肥胖和正常儿童各43例,检测分析所有儿童血清Omentin-1的表达水平,检测分析腰臀比、肌肉量、去脂体重、体脂百分比、内脏脂肪面积和基础代谢率、空腹血糖和胰岛素水平,分析血清Omentin-1与体格指数及胰岛素抵抗水平的关系。

结果

肥胖组儿童的血清Omentin-1水平显著低于正常组,差异具有统计学意义(P<0.001)。肥胖组的腰臀比、肌肉量、去脂体重、体脂百分比、内脏脂肪面积和基础代谢率均显著高于正常组(P<0.001),肥胖组的空腹胰岛素和HOMA-IR水平显著高于正常组(P<0.001),血清Omentin-1水平与腰臀比、体脂百分比、内脏脂肪面积、空腹胰岛素和HOMA-IR呈显著的负相关(P<0.001)。

结论

与正常体重的儿童相比,肥胖儿童的血清Omentin-1显着降低,血清Omentin-1水平与腰臀比、体脂百分比、内脏脂肪面积、空腹胰岛素和HOMA-IR呈显著的负相关。

Objective

To explore the relationship between the expression level of Omentin-1 in children and obesity and insulin resistance.

Methods

A total of 86 children who underwent physical examination Maternal and Child Health Hospital of Yangchun, Guangdong from February 2018 to December 2019 were selected, including 43 obese and normal children each. The serum Omentin-1 expression levels of all children were detected and analyzed. The waist-hip ratio, muscle mass, fat-free weight, body fat percentage, visceral fat area and basal metabolic rate, fasting blood glucose and insulin levels were detected and analyzed, and the relationship between serum Omentin-1 and body mass index and insulin resistance was analyzed.

Results

The serum Omentin-1 level in the obese group was significantly lower than that in the normal group, the difference was statistically significant (P<0.001). The waist-hip ratio, muscle mass, fat-free weight, body fat percentage, visceral fat area and basal metabolic rate in the obese group were significantly higher than those in the normal group (P<0.001). Serum Omentin-1 level was significantly negatively correlated with waist-hip ratio, body fat percentage, visceral fat area, fasting insulin and HOMA-IR (P<0.001).

Conclusions

Compared with normal weight children, serum Omentin-1 is significantly lower in obese children. Serum Omentin-1 levels are significantly negatively correlated with waist-hip ratio, body fat percentage, visceral fat area, fasting insulin and HOMA-IR.

表1 两组患者的一般资料对比
表2 两组患者术后生活质量的比较(±s
表3 两组患者的胰岛素抵抗水平比较
表4 血清Omentin-1与体格资料及胰岛素抵抗水平的相关性分析(n=86)
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