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中华肥胖与代谢病电子杂志 ›› 2026, Vol. 12 ›› Issue (01) : 31 -37. doi: 10.3877/cma.j.issn.2095-9605.2026.01.005

综述

胃袖状切除术后复胖的非手术治疗
杨周舟, 张钊, 詹崇文, 花荣, 姚琪远, 沈奇伟()   
  1. 200040 上海,复旦大学附属华山医院普外科肥胖疝中心
  • 收稿日期:2025-09-25 出版日期:2026-02-28
  • 通信作者: 沈奇伟

Non-surgical treatment methods for weight regain after sleeve gastrectomy

Zhouzhou Yang, Zhao Zhang, Chongwen Zhan, Rong Hua, Qiyuan Yao, Qiwei Shen()   

  1. Center for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2025-09-25 Published:2026-02-28
  • Corresponding author: Qiwei Shen
引用本文:

杨周舟, 张钊, 詹崇文, 花荣, 姚琪远, 沈奇伟. 胃袖状切除术后复胖的非手术治疗[J/OL]. 中华肥胖与代谢病电子杂志, 2026, 12(01): 31-37.

Zhouzhou Yang, Zhao Zhang, Chongwen Zhan, Rong Hua, Qiyuan Yao, Qiwei Shen. Non-surgical treatment methods for weight regain after sleeve gastrectomy[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2026, 12(01): 31-37.

胃袖状切除术(SG)作为目前应用最广泛的减重代谢手术术式,有较高安全性和有效性,但术后复胖率高,对患者预后造成不良影响。目前针对SG术后复胖常用的干预方式为外科修正手术,包括再次SG手术、Roux-en-Y胃旁路术(RYGB)等术式,但外科手术创伤较大,并发症较多,且有再次复胖的风险。因而侵入性更小的非外科手术的方式在治疗SG术后复胖中具有独特优势,目前常用的方式有生活方式干预、心理干预、药物干预和内镜治疗,这些方法通过调节代谢适应、改变生活方式、改善内分泌水平和维持胃容积等多重机制发挥作用,为SG术后体重管理提供了更安全有效的选择。

Sleeve gastrectomy (SG), currently the most widely performed metabolic and bariatric surgery, demonstrates high safety and efficacy. However, the significant postoperative weight regain rate adversely affects patient prognosis. At present, the primary intervention for weight recurrence after SG is surgical revision, including procedures such as re-SG and Roux-en-Y gastric bypass (RYGB). Nevertheless, these surgical approaches are associated with considerable trauma, a higher incidence of complications, and the potential for recurrent weight regain. In contrast, minimally invasive non-surgical interventions offer distinct advantages in managing post-SG weight regain. Current non-surgical strategies include lifestyle modification, psychological intervention, pharmacotherapy, and endoscopic treatments. These methods exert their effects through multiple mechanisms, such as modulating metabolic adaptation, altering lifestyle behaviors, improving endocrine function, and maintaining gastric volume. Collectively, they provide safer and more effective options for postoperative weight management following SG.

[1]
国务院新闻办公室. 中国居民营养与慢性病状况报告(2020年)[R]. 北京, 2020.
[2]
Kim DS, Scherer PE. Obesity, Diabetes, and increased cancer progression [J]. Diabetes Metab J, 2021, 45(6): 799-812.
[3]
Clapp, B, Wynn, M, Martyn C, et al. Long term (7 or more years) outcomes of the sleeve gastrectomy: A meta-analysis [J]. Surg Obes Relat Dis, 2018, 14(6): 741–747.
[4]
Topart P, Becouarn G. One-stage conversion of Roux-en-Y gastric bypass to a modified biliopancreatic diversion with duodenal switch using a hybrid sleeve concep t [J]. Surg Obes Relat Dis, 2016, 12(9): 1671-1678.
[5]
Lauti M, Lemanu D, Zeng ISL, et al. Definition determines weight regain outcomes after sleeve gastrectomy [J]. Surg Obes Relat Dis, 2017, 13(7): 1123-1129.
[6]
Clapp B, Wynn M, Martyn C, et al. Long term (7 or more years) outcomes of the sleeve gastrectomy: a meta-analysis [J]. Surg Obes Relat Dis, 2018, 14(6): 741-747.
[7]
Nuijten MAH, Monpellier VM, Eijsvogels TMH, et al. Rate and determinants of excessive fat-free mass loss after bariatric surgery [J]. Obes Surg, 2020, 30(8): 3119-3126.
[8]
Bettini S, Bordigato E, Fabris R, et al. Modifications of resting energy expenditure after sleeve gastrectomy [J]. Obes Surg, 2018, 28(8): 2481-2486.
[9]
Chu L, Steinberg A, Mehta M, et al. Resting energy expenditure and metabolic adaptation in adolescents at 12 months after bariatric surgery [J]. J Clin Endocrinol Metab, 2025, 33(2), 298-307.
[10]
Barnadas-Solé C, Zerón-Rugerio MF, Hernáez á, et al. Late bedtime is associated with lower weight loss in patients with severe obesity after sleeve gastrectomy [J]. Int J Obes (Lond), 2021, 45(9): 1967-1975.
[11]
Miller-Matero LR, Haley EN, Loree AM, et al. Post-surgical psychiatric symptoms, maladaptive eating patterns, and lifestyle behaviors associated with weight recurrence after bariatric surgery [J]. Surg Obes Relat Dis, 2024, 20(3): 297-303.
[12]
Nicolau J, Sanchís P, Sfondrini G, et al. The EBBS questionnaire (eating behavior after bariatric surgery) is a useful tool for identifying individuals at risk of long-term weight regain after sleeve gastrectomy [J]. Obes Surg, 2025, 35(5), 1769-1778.
[13]
Sarwer DB, Allison KC, Wadden TA, et al. Psychopathology, disordered eating, and impulsivity as predictors of outcomes of bariatric surgery [J]. Surg Obes Relat Dis, 2019, 15(4): 650-655.
[14]
Furtado TDA, Girundi MG, Campolina CDOC, et al. Depressive and eating disorders in patients post-bariatric surgery with weight regain: A descriptive observational study [J]. Arq Bras Cir Dig, 2023, 36: e1725.
[15]
Gafoor R, Booth HP, Gulliford MC. Antidepressant utilisation and incidence of weight gain during 10 years' follow-up: population based cohort study [J]. BMJ. 2018, 23(361): k1951.
[16]
Dias JP, Carlson O, Schweitzer M, et al. GDF15 and cortisol response to meal tolerance test in post-sleeve gastrectomy patients with weight regain [J]. Obes Surg, 2022, 32(8): 2641-2648.
[17]
Alvarez V, Carrasco F, Cuevas A, et al. Mechanisms of long-term weight regain in patients undergoing sleeve gastrectomy [J]. Nutrition, 2016, 32(3): 303-308.
[18]
Kleiman D, Arad Y, Azulai S, et al. Inhibition of somatostatin enhances the long-term metabolic outcomes of sleeve gastrectomy in mice [J]. Mol Metab, 2024, 86: 101979.
[19]
Weiner R A, Weiner S, Pomhoff I, et al. Laparoscopic sleeve gastrectomy-influence of sleeve size and resected gastric volume [J]. Obes Surg, 2007, 17(10): 1297-1305.
[20]
Athanasiadis DI, Martin A, Kapsampelis P, et al. Factors associated with weight regain post-bariatric surgery: a systematic review [J]. Surg Endosc, 2021, 35(8): 4069-4084.
[21]
Carnero EA, Dubis GS, Hames KC, et al. Randomized trial reveals that physical activity and energy expenditure are associated with weight and body composition after RYGB [J]. Obesity, 2017, 25(7): 1206-1216.
[22]
Norooz MT, Safavi-Naini SAA, Jamshidi P, et al. Evaluation of the effects of postsleeve gastrectomy exercise on long-term glucose profile and weight loss among iranian females: a prospective cohort study from 2016 to 2020 [J]. Health Sci Rep, 2025, 8(2): e70431.
[23]
Tasali E, Wroblewski K, Kahn E. et al. Effect of sleep extension on objectively assessed energy intake among adults with overweight in real-life settings: a randomized clinical trial [J]. JAMA Intern Med, 2022,182(4): 365.
[24]
Chou J J, Lee WJ, Almalki O, et al. Dietary intake and weight changes 5 years after laparoscopic sleeve gastrectomy [J]. Obes Surg, 2017, 27(12): 3240-3246.
[25]
Bozdemir H, Usta E, Pehlivan M. The effect of Mediterranean diet adherence and physical activity level on weight loss after laparoscopic sleeve gastrectomy [J/OL]. Obes Surg, 2025: 10.1007/s11695-025-08332-3. [2025-05-08]. https://doi.org/10.1007/s11695-025-08332-3.
[26]
Lauti M, Kularatna M, Pillai A, et al. A Randomised trial of text message support for reducing weight regain following sleeve gastrectomy [J]. Obes Surg, 2018, 28(8): 2178-2186.
[27]
Yang PJ, Chen CL, Chen CN, et al. Early weight loss as a predictor of 3-year weight loss and weight regain in patients with good compliance after sleeve gastrectomy [J]. Surg Obes Relat Dis, 2021, 17(8): 1418-1423.
[28]
Paul L, van der Heiden C, van Hoeken D,et al. Three- and five-year follow-up results of a randomized controlled trial on the effects of cognitive behavioral therapy before bariatric surgery [J]. Int J Eat Disord, 2022, 55(12): 1824-1837.
[29]
Andreu A, Jimenez A, Vidal J, et al. Bariatric support groups predicts long-term weight loss [J]. Obes Surg, 2020, 30(6): 2118-2123.
[30]
Wnuk SM, Du CT, Van-Exan J, et al. Mindfulness-based eating and awareness training for post-bariatric surgery patients: a feasibility pilot study [J]. Mindfulness, 2018, 9(3): 949-960.
[31]
Himes SM, Grothe KB, Clark MM, et al. Stop regain: a pilot psychological intervention for bariatric patients experiencing weight regain [J]. Obes Surg, 2015, 25(5): 922-927.
[32]
Lawlor ER, Islam N, Bates S, et al. Third-wave cognitive behaviour therapies for weight management: A systematic review and network meta-analysis [J]. Obes Rev, 2020, 21(7): e13013.
[33]
Chew HSJ, Chng S, Rajasegaran NN, et al. Effectiveness of acceptance and commitment therapy on weight, eating behaviours and psychological outcomes: A systematic review and meta-analysis [J]. Eating and weight disorders : EWD, 2023, 28(1): 6.
[34]
Sockalingam S, Leung SE, Ma C,et al. Efficacy of telephone-based cognitive behavioral therapy for weight loss, disordered eating, and psychological distress after bariatric surgery: a randomized clinical trial [J]. JAMA Network Open, 2023, 6(8):e2327099.
[35]
Wharton S, Kuk JL, Luszczynski M, et al. Liraglutide 3.0 mg for the management of insufficient weight loss or excessive weight regain post-bariatric surgery [J]. Clin Obes, 2019, 9(4): e12323.
[36]
Thakur U, Bhansali A, Gupta R, et al. Liraglutide augments weight loss after laparoscopic sleeve gastrectomy: a randomised, double-blind, placebo-control study [J]. Obes Surg, 2021, 31(1): 84-92.
[37]
Murvelashvili N, Xie L, Schellinger JN, et al. Effectiveness of semaglutide versus liraglutide for treating post-metabolic and bariatric surgery weight recurrence [J]. Obesity, 2023, 31(5): 1280-1289.
[38]
Bahdi F, Shah S, Dahoud F, et al. Revisional endoscopic sleeve gastroplasty versus semaglutide and tirzepatide for weight recidivism after sleeve gastrectomy [J]. Clin Obes, 2025: e70001.
[39]
Quarenghi M, Capelli S, Galligani G, et al. Weight regain after liraglutide, semaglutide or tirzepatide interruption: a narrative review of randomized studies [J]. J Clin Med, 2025, 14(11): 3791.
[40]
Toth AT, Gomez G, Shukla AP, et al. Weight loss medications in young adults after bariatric surgery for weight regain or inadequate weight loss: a multi-center study [J]. Children(Basel), 2018, 5(9): 116.
[41]
Nor HZ, Nasr EC, Bucak E, et al. Efficacy of adjuvant weight loss medication after bariatric surgery [J]. Surg Obes Relat Dis, 2018, 14(1): 93-98.
[42]
Chen W, Feng J, Dong S,et al. Efficacy and safety of duodenal–jejunal bypass liner for obesity and type 2 diabetes: A systematic review and meta-analysis [J]. Obes Rev, 2024, 25(11): e13812.
[43]
Zhang L, Zhou B, Li Z, et al. Gastric bypass-stent treatment for the suboptimal weight reduction after laparoscopic sleeve gastrectomy [J]. Asian J Surg, 2024, 47(6): 2822-2823.
[44]
Deutsch L, Ben Haim L, Sofer Y, et al. Long-term effects of proximal small bowel exclusion by duodenal-jejunal bypass liner on weight reduction and glycemic control in diabetic patients [J]. Surg Obes Relat Dis, 2018, 14(10): 1561-1569.
[45]
Van Rijn S, Roebroek YGM, De Jonge C,et al. Effect of the endobarrier device: a 4-year follow-up of a multicenter randomized clinical trial [J]. Obes Surg, 2019, 29(4): 1117-1121.
[46]
De Moura, DTH, Barrichello Jr S, De Moura EGH, et al. Endoscopic sleeve gastroplasty in the management of weight regain after sleeve gastrectomy [J]. Endoscopy, 2020, 52(03): 202-210.
[47]
Maselli DB, Alqahtani AR, Abu Dayyeh BK,et al. Revisional endoscopic sleeve gastroplasty of laparoscopic sleeve gastrectomy: An international, multicenter study [J]. Gastrointest Endosc, 2021, 93(1): 122-130.
[48]
Haseeb M, Chhatwal J, Xiao J, et al. Semaglutide vs endoscopic sleeve gastroplasty for weight loss [J]. JAMA Netw Open, 2024, 7(4): e246221.
[49]
Schwartz J, Suzo A, Wehr AM, et al. Pharmacotherapy in conjunction with a diet and exercise program for the treatment of weight recidivism or weight loss plateau post-bariatric surgery: a retrospective review [J]. Obes Surg, 2016, 26(2): 452-458.
[50]
Wadden TA, Bailey TS, Billings LK, et al. Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the step 3 randomized clinical trial [J]. JAMA, 2021325(14): 1403-1413.
[51]
Jensen SBK, Blond MB, Sandsdal RM, et al. Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: A post-treatment analysis of a randomised placebo-controlled trial [J]. EClinicalMedicine, 2024, 69: 102475.
[52]
Ruban A, Glaysher MA, Miras AD, et al. A duodenal sleeve bypass device added to intensive medical therapy for obesity with type 2 diabetes: a RCT [J]. NIHR Journals Library, 2020, 7(6): 1-130.
[53]
Maselli DB, Lee D, Bi D, et al. Safe Continuation of glucagon-like peptide 1 receptor agonists at endoscopy: a case series of 57 adults undergoing endoscopic sleeve gastroplasty [J]. Obes Surg, 2024, 34(7): 2369-2374.
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