| [1] |
Blüher M. Obesity: global epidemiology and pathogenesis[J]. Nature Reviews Endocrinology, 2019, 15(5): 288-298.
|
| [2] |
van Veldhuisen SL, Gorter TM, van Woerden G, et al. Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis[J]. European Heart Journal, 2022, 43(20): 1955-1969.
|
| [3] |
Courcoulas AP, Patti ME, Hu B, et al. Long-term outcomes of medical management vs bariatric surgery in type 2 diabetes [J]. JAMA, 2024, 331(8): 654-664.
|
| [4] |
Reis MG, Guimarães G. Moreira LF, Siqueira Veloso de Andrade Carvalho L, et al. Weight regain after bariatric surgery: A systematic review and meta-analysis of observational studies[J]. Obesity Medicine, 2024, 45: 100528.
|
| [5] |
Madar LO, Goldberg N, Netz U, et al. Association between metabolic and bariatric surgery and malignancy: a systematic review, meta-analysis, trends, and conclusions [J]. Surgery for Obesity and Related Diseases: Official Journal of the American Society for Bariatric Surgery, 2025, 21(4): 434-448.
|
| [6] |
Davey MG, Ryan OK, Ryan éJ, et al. The Impact of Bariatric Surgery on the Incidence of Colorectal Cancer in Patients with Obesity-a Systematic Review and Meta-analysis of Registry Data[J]. Obesity Surgery, 2023, 33(8): 2293-2302.
|
| [7] |
Schauer DP, Feigelson HS, Koebnick C, et al. Bariatric Surgery and the Risk of Cancer in a Large Multisite Cohort [J]. Annals of Surgery, 2019, 269(1): 95-101.
|
| [8] |
Almazeedi S, El-Abd R, Al-Khamis A, et al. Role of bariatric surgery in reducing the risk of colorectal cancer: a meta-analysis[J]. The British Journal of Surgery, 2020, 107(4): 348-354.
|
| [9] |
Janik MR, Clapp B, Sroczyński P, et al. The effect of bariatric surgery on reducing the risk of colorectal cancer: a meta-analysis of 3,233,044 patients[J]. Surgery for Obesity and Related Diseases: Official Journal of the American Society for Bariatric Surgery, 2023, 19(4): 328-334.
|
| [10] |
Kwak M, Mehaffey JH, Hawkins RB, et al. Bariatric surgery is independently associated with a decrease in the development of colorectal lesions[J]. Surgery, 2019, 166(3): 322-326.
|
| [11] |
Ciccioriccio MC, Iossa A, Boru CE, et al. Colorectal cancer after bariatric surgery (Cric-Abs 2020): Sicob (Italian society of obesity surgery) endorsed national survey[J]. International Journal of Obesity, 2021, 45(12): 2527-2531.
|
| [12] |
Chierici A, Amoretti P, Drai C, et al. Does Bariatric Surgery Reduce the Risk of Colorectal Cancer in Individuals with Morbid Obesity? A Systematic Review and Meta-Analysis[J]. Nutrients, 2023, 15(2): 467.
|
| [13] |
Goyal A, Macias CA, Corzo MP, et al. Outcomes of Metabolic and Bariatric Surgery in Populations with Obesity and Their Risk of Developing Colorectal Cancer: Where Do We Stand? An Umbrella Review on Behalf of TROGSS—The Robotic Global Surgical Society[J]. Cancers, 2025, 17(4): 670.
|
| [14] |
Pararas N, Pikouli A, Dellaportas D, et al. The Protective Effect of Bariatric Surgery on the Development of Colorectal Cancer: A Systematic Review and Meta-Analysis[J]. International Journal of Environmental Research and Public Health, 2023, 20(5): 3981.
|
| [15] |
Luo JN, Haridas RS, Lo T, et al. Sleeve gastrectomy promotes colitis-associated colorectal cancer in a murine model via a modified gut microbiome[J]. bioRxiv, 2022: 2022.06.04.494831.
|
| [16] |
Derogar M, Hull MA, Kant P, et al. Increased risk of colorectal cancer after obesity surgery[J]. Annals of Surgery, 2013, 258(6): 983-988.
|
| [17] |
Tao W, Artama M, von Euler-Chelpin M, et al. Colon and rectal cancer risk after bariatric surgery in a multicountry Nordic cohort study[J]. International Journal of Cancer, 2020, 147(3): 728-735.
|
| [18] |
Ostlund MP, Lu Y, Lagergren J. Risk of obesity-related cancer after obesity surgery in a population-based cohort study[J]. Annals of Surgery, 2010, 252(6): 972-976.
|
| [19] |
Lim PW, Stucky CCH, Wasif N, et al. Bariatric Surgery and Longitudinal Cancer Risk: A Review[J]. JAMA surgery, 2024, 159(3): 331-338.
|
| [20] |
Liu YN, Gu JF, Zhang J, et al. Bariatric surgery reduces colorectal cancer incidence in obese individuals: Systematic review and meta-analysis[J]. World Journal of Gastrointestinal Surgery, 2023, 15(10): 2331-2342.
|
| [21] |
Renehan AG, Tyson M, Egger M, et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies[J]. Lancet (London, England), 2008, 371(9612): 569-578.
|
| [22] |
Larsson SC, Wolk A. Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies[J]. The American Journal of Clinical Nutrition, 2007, 86(3): 556-565.
|
| [23] |
Peleg N, Sapoznikov S, Levi Z, et al. Incidence of Colorectal Adenomas After Bariatric Surgery: Pre-operative Super Morbid Obesity Is Independently Associated with Increased Risk[J]. Obesity Surgery, 2021, 31(10): 4220-4226.
|
| [24] |
Mackenzie H, Markar SR, Askari A, et al. Obesity surgery and risk of cancer[J]. The British Journal of Surgery, 2018, 105(12): 1650-1657.
|
| [25] |
Hussan H, Drosdak A, Le Roux M, et al. The Long-term Impact of Roux-en-Y Gastric Bypass on Colorectal Polyp Formation and Relation to Weight Loss Outcomes[J]. Obesity Surgery, 2020, 30(2): 407-415.
|
| [26] |
Hussan H, Akinyeye S, Mihaylova M, et al. Colorectal Cancer Risk Is Impacted by Sex and Type of Surgery After Bariatric Surgery[J]. Obesity Surgery, 2022, 32(9): 2880-2890.
|
| [27] |
Kant P, Sainsbury A, Reed KR, et al. Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB[J]. Gut, 2011, 60(7): 893-901.
|
| [28] |
Sainsbury A, Goodlad RA, Perry SL, et al. Increased colorectal epithelial cell proliferation and crypt fission associated with obesity and roux-en-Y gastric bypass[J]. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2008, 17(6): 1401-1410.
|
| [29] |
Guo Y, Liu CQ, Liu GP, et al. Roux-en-Y gastric bypass decreases endotoxemia and inflammatory stress in association with improvements in gut permeability in obese diabetic rats[J]. Journal of Diabetes, 2019, 11(10): 786-793.
|
| [30] |
Ayiomamitis GD, Notas G, Vasilakaki T, et al. Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis[J]. Cancers, 2019, 11(10): 1536.
|
| [31] |
Hussan H, Clinton SK, Grainger EM, et al. Distinctive patterns of sulfide- and butyrate-metabolizing bacteria after bariatric surgery: potential implications for colorectal cancer risk[J]. Gut Microbes, 2023, 15(2): 2255345.
|
| [32] |
Graessler J, Qin Y, Zhong H, et al. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters[J]. The Pharmacogenomics Journal, 2013, 13(6): 514-522.
|
| [33] |
Mabey JG, Chaston JM, Castro DG, et al. Gut microbiota differs a decade after bariatric surgery relative to a nonsurgical comparison group[J]. Surgery for Obesity and Related Diseases: Official Journal of the American Society for Bariatric Surgery, 2020, 16(9): 1304-1311.
|
| [34] |
Debédat J, Clément K, Aron-Wisnewsky J. Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery[J]. Current Obesity Reports, 2019, 8(3): 229-242.
|
| [35] |
Koulas SG, Stefanou CK, Stefanou SK, et al. Gut Microbiota in Patients with Morbid Obesity Before and After Bariatric Surgery: a Ten-Year Review Study (2009-2019)[J]. Obesity Surgery, 2021, 31(1): 317-326.
|
| [36] |
Palmisano S, Campisciano G, Iacuzzo C, et al. Role of preoperative gut microbiota on colorectal anastomotic leakage: preliminary results[J]. Updates in Surgery, 2020, 72(4): 1013-1022.
|
| [37] |
Wang L, Tang L, Feng Y, et al. A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice[J]. Gut, 2020, 69(11): 1988-1997.
|
| [38] |
Jiang Y, Xu Y, Zheng C, et al. Acetyltransferase from Akkermansia muciniphila blunts colorectal tumourigenesis by reprogramming tumour microenvironment[J]. Gut, 2023, 72(7): 1308-1318.
|
| [39] |
Fan L, Xu C, Ge Q, et al. A. Muciniphila Suppresses Colorectal Tumorigenesis by Inducing TLR2/NLRP3-Mediated M1-Like TAMs[J]. Cancer Immunology Research, 2021, 9(10): 1111-1124.
|
| [40] |
Zhou L, Zhang M, Wang Y, et al. Faecalibacterium prausnitzii Produces Butyrate to Maintain Th17/Treg Balance and to Ameliorate Colorectal Colitis by Inhibiting Histone Deacetylase 1[J]. Inflammatory Bowel Diseases, 2018, 24(9): 1926-1940.
|
| [41] |
Dikeocha IJ, Al-Kabsi AM, Chiu HT, et al. Faecalibacterium prausnitzii Ameliorates Colorectal Tumorigenesis and Suppresses Proliferation of HCT116 Colorectal Cancer Cells[J]. Biomedicines, 2022, 10(5): 1128.
|
| [42] |
Li JV, Reshat R, Wu Q, et al. Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents[J]. Frontiers in Microbiology, 2011, 2: 183.
|
| [43] |
Abed J, Emgård JEM, Zamir G, et al. Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc[J]. Cell Host & Microbe, 2016, 20(2): 215-225.
|
| [44] |
Glymenaki M, Curio S, Shrestha S, et al. Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation[J]. Microbiome, 2025, 13(1): 60.
|
| [45] |
Pournaras DJ, Glicksman C, Vincent RP, et al. The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control[J]. Endocrinology, 2012, 153(8): 3613-3619.
|
| [46] |
Patti ME, Houten SM, Bianco AC, et al. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism[J]. Obesity (Silver Spring, Md.), 2009, 17(9): 1671-1677.
|
| [47] |
Chaudhari SN, Luo JN, Harris DA, et al. A microbial metabolite remodels the gut-liver axis following bariatric surgery[J]. Cell Host & Microbe, 2021, 29(3): 408-424.e7.
|
| [48] |
Wang M, Li L, Chen Y, et al. Role of Gut Microbiome and Microbial Metabolites in Alleviating Insulin Resistance After Bariatric Surgery[J]. Obesity Surgery, 2021, 31(1): 327-336.
|
| [49] |
Cai J, Sun L, Gonzalez FJ. Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis[J]. Cell Host & Microbe, 2022, 30(3): 289-300.
|
| [50] |
Bayerdörffer E, Mannes GA, Richter WO, et al. Increased serum deoxycholic acid levels in men with colorectal adenomas[J]. Gastroenterology, 1993, 104(1): 145-151.
|
| [51] |
Bernstein C, Holubec H, Bhattacharyya AK, et al. Carcinogenicity of deoxycholate, a secondary bile acid[J]. Archives of Toxicology, 2011, 85(8): 863-871.
|
| [52] |
Nguyen TT, Ung TT, Kim NH, et al. Role of bile acids in colon carcinogenesis[J]. World Journal of Clinical Cases, 2018, 6(13): 577-588.
|
| [53] |
Jia W, Xie G, Jia W. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis[J]. Nature Reviews. Gastroenterology & Hepatology, 2018, 15(2): 111-128.
|
| [54] |
Nguyen TT, Ung TT, Li S, et al. Metformin inhibits lithocholic acid-induced interleukin 8 upregulation in colorectal cancer cells by suppressing ROS production and NF-kB activity[J]. Scientific Reports, 2019, 9(1): 2003.
|
| [55] |
Lässle C, Mauerer B, Marx L, et al. Metabolic surgery reduces CRC disease progression through circulating bile acid diversion[J]. Science Translational Medicine, 2025, 17(804): eads9705.
|
| [56] |
D’Amato S, Sofia M, Agosta M, et al. The impact of bariatric surgery on colorectal cancer risk[J]. Surgery for Obesity and Related Diseases: Official Journal of the American Society for Bariatric Surgery, 2023, 19(2): 144-157.
|
| [57] |
Monleón D, Morales JM, Barrasa A, et al. Metabolite profiling of fecal water extracts from human colorectal cancer[J]. NMR in biomedicine, 2009, 22(3): 342-348.
|
| [58] |
Walker AW, Duncan SH, McWilliam Leitch EC, et al. pH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon[J]. Applied and Environmental Microbiology, 2005, 71(7): 3692-3700.
|
| [59] |
Juárez-Fernández M, Román-Sagüillo S, Porras D, et al. Long-Term Effects of Bariatric Surgery on Gut Microbiota Composition and Faecal Metabolome Related to Obesity Remission[J]. Nutrients, 2021, 13(8): 2519.
|
| [60] |
Seyfried F, Phetcharaburanin J, Glymenaki M, et al. Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss[J]. Gut Microbes, 2021, 13(1): 1-20.
|
| [61] |
Martínez-Sánchez MA, Balaguer-Román A, Fernández-Ruiz VE, et al. Plasma short-chain fatty acid changes after bariatric surgery in patients with severe obesity[J]. Surgery for Obesity and Related Diseases: Official Journal of the American Society for Bariatric Surgery, 2023, 19(7): 727-734.
|
| [62] |
Huang X, Oshima T, Tomita T, et al. Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels[J]. Biology, 2021, 10(3): 205.
|
| [63] |
Cunningham RM, Jones KT, Kuhn JE, et al. Asymptomatic Cholelithiasis and Bariatric Surgery: a Comprehensive Long-Term Analysis of the Risks of Biliary Disease in Patients Undergoing Primary Roux-en-Y Gastric Bypass[J]. Obesity Surgery, 2021, 31(3): 1249-1255.
|
| [64] |
Tang B, Li S, Li X, et al. Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis[J]. Nature Communications, 2025, 16(1): 7638.
|
| [65] |
Devkota S, Wang Y, Musch MW, et al. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice[J]. Nature, 2012, 487(7405): 104-108.
|
| [66] |
Sheng L, Jena PK, Hu Y, et al. Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation[J]. The Journal of Pathology, 2017, 243(4): 431-441.
|
| [67] |
Ghenu MI, Dragoş D, Manea MM, et al. Pathophysiology of sepsis-induced cholestasis: A review[J]. JGH open: an open access journal of gastroenterology and hepatology, 2022, 6(6): 378-387.
|
| [68] |
Song L, Hou Y, Xu D, et al. Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress[J]. Cell Metabolism, 2025, 37(1): 104-120.e9.
|