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中华肥胖与代谢病电子杂志 ›› 2025, Vol. 11 ›› Issue (04) : 311 -317. doi: 10.3877/cma.j.issn.2095-9605.2025.04.008

综述

蛋白质乳酸化修饰参与肥胖发病机制的研究进展
黄思远1,2,3, 杨玉彬1,2,(), 李海蓉4, 张琳莉5, 王艺霖6, 张珣6   
  1. 1610044 成都,四川大学华西第二医院中医科
    2610000 成都,出生缺陷与相关妇儿疾病教育部重点实验室
    3210023 南京,南京中医药大学中西医结合学院
    4510000 广州,广东药科大学中药学院
    5610041 成都,四川大学华西口腔医学院
    6610041 成都,四川大学华西临床医学院
  • 收稿日期:2024-07-16 出版日期:2025-11-30
  • 通信作者: 杨玉彬
  • 基金资助:
    国家自然科学基金青年基金(82574822); 广东省基础与应用基础研究基金省企联合基金面上项目(2023A1515220146)

Research progress on the involvement of protein lactylation in the pathogenesis of obesity

Siyuan Huang1,2,3, Yubin Yang1,2,(), Hairong Li4, Linli Zhang5, Yilin Wang6, Xun Zhang6   

  1. 1Department of Traditional Chinese Medicine, West China Second University Hospital, Sichuan University, Chengdu, 610044, China
    2Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, 610000
    3School of Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
    4School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 5100063, China
    5West China School of Stomatology, Sichuan University, Chengdu 610041, China
    6West China School of Clinical Medicine, Sichuan University, Chengdu, 610041, China
  • Received:2024-07-16 Published:2025-11-30
  • Corresponding author: Yubin Yang
引用本文:

黄思远, 杨玉彬, 李海蓉, 张琳莉, 王艺霖, 张珣. 蛋白质乳酸化修饰参与肥胖发病机制的研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2025, 11(04): 311-317.

Siyuan Huang, Yubin Yang, Hairong Li, Linli Zhang, Yilin Wang, Xun Zhang. Research progress on the involvement of protein lactylation in the pathogenesis of obesity[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2025, 11(04): 311-317.

肥胖已成为全球性的公共卫生问题,是代谢紊乱与多种慢性疾病的诱因及后果,受多种生命过程调节。近年来,新型的蛋白质翻译后修饰(PTMs)——蛋白质乳酸化修饰(protein lactylation),通过基因转录、细胞命运、炎症反应、肿瘤以及代谢等多个生理和病理过程直接或间接参与肥胖病理机制,并逐渐成为研究热点。但目前对蛋白质乳酸化修饰在肥胖调控机制中的系统总结比较匮乏。本综述以乳酸的产生及功能为切入点,系统介绍乳酸化修饰之生化基础、检测方法和生物学功能,再从乳酸化修饰介导炎性信号通路、诱导胰岛素抵抗、影响葡萄糖摄取利用与糖酵解过程、干扰脂质代谢四个方面进行探讨,聚焦其在肥胖调控中的潜在作用和机制,最后提出了未来可能的研究方向和挑战。

Objective

has become a global public health issue, serving as both a cause and consequence of metabolic disorders and various chronic diseases, and is regulated by multiple biological processes. In recent years, protein lactylation, a novel post-translational modification (PTM), has been found to directly or indirectly participate in the pathophysiology of obesity through multiple physiological and pathological processes, including gene transcription, cell fate, inflammation, tumor development, and metabolism. It has gradually become a research hotspot. However, there is currently a lack of systematic reviews on the regulatory mechanisms of protein lactylation in obesity. This review begins with the production and function of lactate, systematically introduces the biochemical basis, detection methods, and biological functions of lactylation, and then explores its involvement in obesity by examining four key aspects: lactylation-mediated inflammatory signaling pathways, the induction of insulin resistance, its effects on glucose uptake and glycolysis, and its interference with lipid metabolism. The focus is placed on its potential roles and mechanisms in obesity regulation, and finally, potential future research directions and challenges are proposed.

图1 蛋白质乳酸化修饰参与肥胖发病机制过程
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