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中华肥胖与代谢病电子杂志 ›› 2025, Vol. 11 ›› Issue (02) : 148 -152. doi: 10.3877/cma.j.issn.2095-9605.2025.02.010

综述

骨形态发生蛋白调控棕色脂肪细胞在代谢疾病中的相关研究进展
苟晓燕1, 范小萍1, 邹冉1, 撒亚莲2, 李勇1,()   
  1. 1629099 遂宁,遂宁市中心医院放射科
    2650034 昆明,云南省第一人民医院临床研究中心
  • 收稿日期:2024-09-12 出版日期:2025-05-30
  • 通信作者: 李勇
  • 基金资助:
    国家自然科学基金(82060028)

Research progress of bone morphogenetic proteins regulation on brown fat cells

Xiaoyan Gou1, Xiaoping Fan1, Ran Zou1, Yalian Sa2, Yong Li1,()   

  1. 1Department of Radiology, Suining Central Hospital of Sichuan Province, Suinin 629099, China
    2Clinical Research Center, The First People's Hospital of Yunnan Province, Kunming 650034, China
  • Received:2024-09-12 Published:2025-05-30
  • Corresponding author: Yong Li
引用本文:

苟晓燕, 范小萍, 邹冉, 撒亚莲, 李勇. 骨形态发生蛋白调控棕色脂肪细胞在代谢疾病中的相关研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2025, 11(02): 148-152.

Xiaoyan Gou, Xiaoping Fan, Ran Zou, Yalian Sa, Yong Li. Research progress of bone morphogenetic proteins regulation on brown fat cells[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2025, 11(02): 148-152.

骨形态发生蛋白(BMPs)是TGF-β超家族中的一员,主要调控胚胎发育、分化等多个关键步骤,可通过I型受体(即激活素受体样激酶,ALK1、2、3或6)及II型受体中2A或2B激活SMAD1/5/8通路将信息传递到细胞核。棕色脂肪组织(BAT)是一种独特的产热组织,近年已成为对抗肥胖、糖尿病等代谢疾病的研究热点。BMP2、4、6、7、8b、14及MB109在棕色脂肪的发育、成熟脂肪细胞的代谢调控方面发挥重要作用。本文就BMPs在棕色脂肪相关信号通路中的调控作用及代谢相关疾病治疗的潜在应用进行总结,以期为临床上以棕色脂肪为靶点治疗相关代谢性疾病提供参考。

Bone morphogenetic proteins (BMPs) are members of the TGF-β family, which regulate key processes such as embryonic development and differentiation. The SMAD1/5/8 pathway is activated by type I receptors (activin receptor-like Kinase ALK 1, 2, 3 or 6) and type II receptors (2A or 2B). Brown adipose tissue is a unique thermogenic tissue that has emerged as a focal point in addressing obesity, diabetes, and other metabolic diseases in recent years. BMP2, 4, 6, 7, 8b, 14, and MB109 have been demonstrated to play an increasingly significant role in the development of brown adipose tissue and the metabolic regulation of mature adipocytes. This article summarizes the regulatory role of BMPs in brown adipose-related signaling pathways and their potential application in the treatment of metabolic diseases, thereby providing a reference for the clinical treatment of metabolic diseases with brown adipose-targeted approaches.

表1 BMPS成员与棕色脂肪的相关研究
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