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中华肥胖与代谢病电子杂志 ›› 2024, Vol. 10 ›› Issue (01) : 21 -26. doi: 10.3877/cma.j.issn.2095-9605.2024.01.004

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肥胖及减重手术与下肢骨关节炎的研究进展
詹崇文1, 沈奇伟2, 姚琪远1,()   
  1. 1. 200040 上海,复旦大学附属华山医院普外科
    2. 200040 上海,复旦大学附属华山医院肥胖疝外科
  • 收稿日期:2023-10-18 出版日期:2024-02-29
  • 通信作者: 姚琪远
  • 基金资助:
    国家自然科学基金(81800751,81970458)

Research progress on lower limb osteoarthritis affected by obesity and bariatric surgery

Chongwen Zhan1, Qiwei Shen2, Qiyuan Yao1,()   

  1. 1. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China
    2. Center for Obesity and Hernia Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2023-10-18 Published:2024-02-29
  • Corresponding author: Qiyuan Yao
引用本文:

詹崇文, 沈奇伟, 姚琪远. 肥胖及减重手术与下肢骨关节炎的研究进展[J/OL]. 中华肥胖与代谢病电子杂志, 2024, 10(01): 21-26.

Chongwen Zhan, Qiwei Shen, Qiyuan Yao. Research progress on lower limb osteoarthritis affected by obesity and bariatric surgery[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(01): 21-26.

肥胖可通过生物力学和全身炎症促进下肢骨关节炎的发生发展,进而造成关节结构损伤、功能受限。减重手术作为治疗肥胖最有效的方法之一,可以有效缓解关节症状、减缓甚至逆转骨关节炎的进展。本文从肥胖与下肢骨关节炎发生的相关性及潜在机制,综述肥胖在下肢骨关节炎发生中的作用。此外,本文针对减重手术对肥胖患者下肢骨关节炎的疗效及机制进行了总结,以期为肥胖患者骨关节炎的治疗提供新的思路和方向。

Obesity promotes the pathogenesis of osteoarthritis of the lower extremities through biomechanical and systemic inflammatory changes, which result in structural damage to the joint and limited function. Bariatric surgery is one of the most effective methods to treat obesity, which can effectively relieve joint symptoms and slow or even reverse the progression of osteoarthritis. This article reviews the role of obesity in developing lower limb osteoarthritis from the correlation and potential mechanism between obesity and osteoarthritis. In addition, this article summarizes the effect and mechanism of bariatric surgery on lower limb osteoarthritis in obese patients to provide new ideas and directions for the treatment of obese patients with osteoarthritis.

图1 肥胖导致下肢骨关节炎的机制
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