切换至 "中华医学电子期刊资源库"

中华肥胖与代谢病电子杂志 ›› 2023, Vol. 09 ›› Issue (04) : 267 -273. doi: 10.3877/cma.j.issn.2095-9605.2023.04.007

综述

代谢综合征与动脉粥样硬化性疾病相关性研究现状与进展
钱昊1, 李振振1,()   
  1. 1. 570311 海口,海南医学院附属海南医院·海南省人民医院血管外科
  • 收稿日期:2023-11-01 出版日期:2023-11-30
  • 通信作者: 李振振
  • 基金资助:
    海南省自然科学基金资助项目(820MS135); 海南省卫生健康委员会2023年度省级临床重点学科(临床医学中心)建设单位基金资助项目(琼卫医函[2022]341号); 海南省卫生健康科技创新联合项目(WSJK2024MS209)

Current status and research progress of the association between metabolic syndrome and atherosclerotic disease

Hao Qian1, Zhenzhen Li1,()   

  1. 1. Department of Vascular Surgery, Affiliated Hainan Hospital of Hainan Medical University, Hainan Provincial People's Hospital, Haikou 570311, China
  • Received:2023-11-01 Published:2023-11-30
  • Corresponding author: Zhenzhen Li
引用本文:

钱昊, 李振振. 代谢综合征与动脉粥样硬化性疾病相关性研究现状与进展[J]. 中华肥胖与代谢病电子杂志, 2023, 09(04): 267-273.

Hao Qian, Zhenzhen Li. Current status and research progress of the association between metabolic syndrome and atherosclerotic disease[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2023, 09(04): 267-273.

代谢综合征(MetS)是一组代谢异常的集合,并与心血管疾病(ASCVD)、2型糖尿病(T2DM)等健康问题紧密相关。随着对MetS认知的不断深入,其诊断标准日益精确化。MetS与动脉粥样硬化性疾病的相关性背后涉及氧化应激(OS)、胰岛素抵抗(IR)、长期慢性炎症和血脂紊乱等诸多机制。本文将深入探讨MetS与动脉粥样硬化及其各方面的联系。此外,未来研究需明确MetS导致动脉粥样硬化的具体机制,评估潜在的生物标志物,并持续优化治疗策略。

Metabolic syndrome (MetS) is a collection of metabolic abnormalities that are strongly associated with health issues such as arteriosclerotic cardiovascular disease (ASCVD) and type 2 diabetes mellitus (T2DM). With the growing awareness of MetS and the increasing precision of its diagnostic criteria, the widespread prevalence of MetS is indisputable. The mechanisms behind the association of MetS with atherosclerotic diseases involve oxidative stress (OS), insulin resistance (IR), long-term chronic inflammation, and dyslipidemia, among many others. This paper will delve into the link between MetS and atherosclerosis and its various aspects. In addition, future studies need to clarify the specific mechanisms by which MetS leads to atherosclerosis, evaluate potential biomarkers, and continue to optimize therapeutic strategies.

[1]
Paixão TM, Teixeira LR, Andrade CAF, et al. Systematic Review and Meta-Analysis of Metabolic Syndrome and Its Components in Latino Immigrants to the USA [J]. Int J Environ Res Public Health, 2023, 20(2): 1307.
[2]
Huang Y, Zhang L, Wang Z, et al. The prevalence and characteristics of metabolic syndrome according to different definitions in China: a nationwide cross-sectional study, 2012-2015 [J]. BMC Public Health, 2022, 22(1): 1869.
[3]
Kong P, Cui ZY, Huang XF, et al. Inflammation and atherosclerosis: signaling pathways and therapeutic intervention [J]. Signal Transduct Target Ther, 2022, 7(1): 131.
[4]
Xu JJ, Song Y, Jiang P, et al. Eff ects of metabolic syndrome on onset age and long-term outcomes in patients with acute coronary syndrome [J]. World J Emerg Med, 2021, 12(1): 36-41.
[5]
Opio J, Wynne K, Attia J, et al. Overweight or obesity increases the risk of cardiovascular disease among older Australian adults, even in the absence of cardiometabolic risk factors: a Bayesian survival analysis from the Hunter Community Study [J]. Int J Obes (Lond), 2023, 47(2): 117-125.
[6]
Iso H, Cui R, Takamoto I, et al. Risk Classification for Metabolic Syndrome and the Incidence of Cardiovascular Disease in Japan With Low Prevalence of Obesity: A Pooled Analysis of 10 Prospective Cohort Studies [J]. J Am Heart Assoc, 2021, 10(23): e020760.
[7]
Alshammary AF, Alharbi KK, Alshehri NJ, et al. Metabolic Syndrome and Coronary Artery Disease Risk: A Meta-Analysis of Observational Studies [J]. Int J Environ Res Public Health, 2021, 18(4): 1773.
[8]
Li X, Li X, Lin H, et al. Metabolic syndrome and stroke: A meta-analysis of prospective cohort studies [J]. J Clin Neurosci, 2017, 40: 34-38.
[9]
Zhang F, Liu L, Zhang C, et al. Association of Metabolic Syndrome and Its Components With Risk of Stroke Recurrence and Mortality: A Meta-analysis [J]. Neurology, 2021, 97(7): e695-e705.
[10]
Cho JH, Rhee EJ, Park SE, et al. The Risk of Myocardial Infarction and Ischemic Stroke According to Waist Circumference in 21 749 261 Korean Adults: A Nationwide Population-Based Study [J]. Diabetes Metab J, 2019, 43(2): 206-221.
[11]
Liu X, Zhang D, Liu Y, et al. A J-shaped relation of BMI and stroke: Systematic review and dose-response meta-analysis of 4.43 million participants [J]. Nutr Metab Cardiovasc Dis, 2018, 28(11): 1092-1099.
[12]
Chen W, Pan Y, Jing J, et al. Recurrent Stroke in Minor Ischemic Stroke or Transient Ischemic Attack With Metabolic Syndrome and/or Diabetes Mellitus [J]. J Am Heart Assoc, 2017, 6(6): e005446.
[13]
Huang Q, Yin L, Liu Z, et al. Association of novel lipid indicators with the risk of stroke among participants in Central China: a population-based prospective study [J]. Front Endocrinol (Lausanne). 2023.14:1266552.
[14]
Liu Z, Huang Q, Deng B, et al. Elevated Chinese visceral adiposity index increases the risk of stroke in Chinese patients with metabolic syndrome [J]. Front Endocrinol (Lausanne), 2023, 14: 1218905.
[15]]
Bauersachs R, Zeymer U, Brière JB, et al. Burden of Coronary Artery Disease and Peripheral Artery Disease: A Literature Review [J]. Cardiovasc Ther, 2019, 2019: 8295054.
[16]
Soriano-Moreno DR, Fernandez-Morales J, Medina-Ramirez SA, et al. Metabolic Syndrome and Risk of Peripheral Arterial Disease: A Systematic Review and Meta-Analysis [J]. Cardiol Rev, 2022.
[17]
Gami A, Witt B, Howard D, et al. Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death: A Systematic Review and Meta-Analysis of Longitudinal Studies [J]. J Am Coll Cardiol, 2007, 49(4): 403-414.
[18]
Maksimovic M, Vlajinac H, Radak D, et al. Relationship between peripheral arterial disease and metabolic syndrome [J]. Angiology, 2009, 60(5): 546-553.
[19]
Gao L, Zhao W, Liu Q, et al. Association Between Metabolic Syndrome and Peripheral Arterial Disease in Elderly Patients with Type 2 Diabetes [J]. Diabetes Metab Syndr Obes, 2021, 14: 4783-4789.
[20]
Chen Q, Zhu H, Shen F, et al. Sex-influenced association of metabolic syndrome with lower extremity arterial disease in type 2 diabetes [J]. J Diabetes Complications, 2020, 34(5): 107537.
[21]
Masenga SK, Kabwe LS, Chakulya M, et al. Mechanisms of Oxidative Stress in Metabolic Syndrome [J]. Int J Mol Sci, 2023, 24(9): 7898.
[22]
Aboonabi A, Meyer RR, Singh I. The association between metabolic syndrome components and the development of atherosclerosis [J]. J Hum Hypertens, 2019, 33(12): 844-855.
[23]
Vergès B. Pathophysiology of diabetic dyslipidaemia: where are we? [J]. Diabetologia, 2015, 58(5): 886-899.
[24]
Förstermann U, Xia N, Li H. Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis [J]. Circ Res, 2017, 120(4): 713-735.
[25]
Mitra R, O'Neil GL, Harding IC, et al. Glycocalyx in Atherosclerosis-Relevant Endothelium Function and as a Therapeutic Target [J]. Curr Atheroscler Rep, 2017, 19(12): 63.
[26]
Förstermann U, Xia N, Li H. Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis [J]. Circ Res, 2017, 120(4): 713-735.
[27]
Torres S, Fabersani E, Marquez A, et al. Adipose tissue inflammation and metabolic syndrome. The proactive role of probiotics [J]. Eur J Nutr, 2019, 58(1): 27-43.
[28]
Saltiel AR, Olefsky JM. Inflammatory mechanisms linking obesity and metabolic disease [J]. J Clin Invest, 2017, 127(1): 1-4.
[29]
Wu J, He S, Song Z, et al. Macrophage polarization states in atherosclerosis [J]. Front Immunol, 2023, 14: 1185587.
[30]
Zhang S, Gang X, Yang S, et al. The Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases [J]. Front Immunol, 2021, 12: 678355.
[31]
Kang SG, Piniecki RJ, Hogenesch H, et al. Identification of a Chemokine Network That Recruits FoxP3+ Regulatory T Cells Into Chronically Inflamed Intestine [J]. Gastroenterology, 2007, 132(3): 966-981.
[32]]
van Diepen JA, Berbée JF, Havekes LM, et al. Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis [J]. Atherosclerosis, 2013, 228(2): 306-315.
[33]
O'Neill BJ. Effect of low-carbohydrate diets on cardiometabolic risk, insulin resistance, and metabolic syndrome [J]. Curr Opin Endocrinol Diabetes Obes, 2020, 27(5): 301-307.
[34]
Stanek A, Brożyna-Tkaczyk K, Zolghadri S, et al. The Role of Intermittent Energy Restriction Diet on Metabolic Profile and Weight Loss among Obese Adults [J]. Nutrients, 2022, 14(7): 1509.
[35]
Xu R, Cao Y, Wang PY, et al. Intermittent energy restriction vs. continuous energy restriction on cardiometabolic risk factors in patients with metabolic syndrome: a meta-analysis and systematic review [J]. Front Nutr, 2023, 10: 1090792.
[36]
Alkhulaifi F, Darkoh C. Meal Timing, Meal Frequency and Metabolic Syndrome [J]. Nutrients, 2022, 14(9): 1719.
[37]
Franczyk B, Gluba-Brzózka A, Ciałkowska-Rysz A, et al. The Impact of Aerobic Exercise on HDL Quantity and Quality: A Narrative Review [J]. Int J Mol Sci, 2023, 24(5): 4653.
[38]
Battista F, Ermolao A, van Baak MA, et al. Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat-A systematic review and meta-analysis [J]. Obes Rev, 2021, 22(Suppl 4): e13269.
[39]
Bray GA, Greenway FL. Pharmacological treatment of the overweight patient [J]. Pharmacol Rev, 2007, 59(2): 151-184.
[40]
Chao AM, Tronieri JS, Amaro A, et al. Semaglutide for the treatment of obesity [J]. Trends Cardiovasc Med, 2023, 33(3): 159-166.
[41]
Merćep I, Vujević A, Strikić D, et al. Present and Future of Dyslipidaemia Treatment-A Review [J]. J Clin Med, 2023, 12(18): 5839.
[42]
Katsimardou A, Imprialos K, Stavropoulos K, et al. Hypertension in Metabolic Syndrome: Novel Insights [J]. Curr Hypertens Rev, 2020, 16(1): 12-18.
[43]
Castrejón-Téllez V, Villegas-Romero M, Rubio-Ruiz ME, et al. Effect of a Resveratrol/Quercetin Mixture on the Reversion of Hypertension Induced by a Short-Term Exposure to High Sucrose Levels Near Weaning and a Long-Term Exposure That Leads to Metabolic Syndrome in Rats [J]. Int J Mol Sci, 2020, 21(6): 2231.
[44]
Villegas Vílchez LF, Ascencios JH, Dooley TP. GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome [J]. BMC Complement Med Ther, 2022, 22(1): 62.
[45]
Chandrakumar H, Khatun N, Gupta T, et al. The Effects of Bariatric Surgery on Cardiovascular Outcomes and Cardiovascular Mortality: A Systematic Review and Meta-Analysis [J]. Cureus, 2023, 15(2): e34723.
[46]
Ardissino M, Watson F, Amin R, et al. Atherosclerotic disease burden after bariatric surgery in patients with obesity and type 2 diabetes [J]. J Diabetes, 2021, 13(8): 640-647.
[47]
Yang W, Zhan M, Li Z, et al. Major Adverse Cardiovascular Events Among Obese Patients with Diabetes After Metabolic and Bariatric Surgery: a Meta-analysis of Matched Cohort and Prospective Controlled Studies with 122,361 Participates [J]. Obes Surg, 2023, 33(7): 2098-2107.
[48]
Arias A, Rodríguez-álvarez C, González-Dávila E, Acosta-Torrecilla A, Novo-Muñoz MM, Rodríguez-Novo N. Arterial Hypertension in Morbid Obesity after Bariatric Surgery: Five Years of Follow-Up, a Before-And-After Study [J]. Int J Environ Res Public Health, 2022, 19(3): 1575.
[49]
Valera RJ, Sarmiento-Cobos M, Montorfano L, et al. The impact of bariatric surgery on hospitalization due to peripheral artery disease and critical limb ischemia: a nationwide analysis [J]. Surg Obes Relat Dis. 2023, 19(10):1162-1168.
[50]
Moussa O, Ardissino M, Muttoni S, et al. Long-term incidence and outcomes of obesity-related peripheral vascular disease after bariatric surgery [J]. Langenbecks Arch Surg, 2021, 406(4): 1029-1036.
[51]
Kirwan JP, Courcoulas AP, Cummings DE, et al. Diabetes Remission in the Alliance of Randomized Trials of Medicine Versus Metabolic Surgery in Type 2 Diabetes (ARMMS-T2D) [J]. Diabetes Care, 2022, 45(7): 1574-1583.
[52]
杨华, 张鹏, 董志勇, 等. 中国肥胖代谢外科手术方式推荐立场声明 [J/CD]. 中华肥胖与代谢病电子杂志, 2021, 7(1): 8-12.
[1] 何金梅, 尹立雪, 谭静, 张文军, 王锐, 任梅, 廖明娇. 超声心肌做功技术对2型糖尿病患者潜在左心室心肌收缩功能损伤的评价[J]. 中华医学超声杂志(电子版), 2023, 20(10): 1029-1035.
[2] 马艳波, 华扬, 刘桂梅, 孟秀峰, 崔立平. 中青年人颈动脉粥样硬化病变的相关危险因素分析[J]. 中华医学超声杂志(电子版), 2023, 20(08): 822-826.
[3] 黄跃明, 古晨, 杨志锋, 郭志刚, 王尧, 雒洪志. 停留皮下引流管预防肥胖患者急诊剖腹探查术后切口感染140例分析[J]. 中华普通外科学文献(电子版), 2024, 18(01): 34-38.
[4] 刘超凡, 王文越, 杨珵璨, 朱冬梓, 王兵. 胃袖状切除术上调循环Nrg4浓度抑制肝脏脂肪酸合成改善肥胖小鼠肝脏脂肪变性[J]. 中华普外科手术学杂志(电子版), 2024, 18(02): 133-136.
[5] 赵帅, 王伟, 李瑞奇, 周家杰, 王道荣. 3D腹腔镜下袖状胃切除术治疗肥胖合并2型糖尿病的临床疗效及影响因素分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(02): 146-149.
[6] 刘盾, 潘晟. 不同入路腹腔镜袖状胃切除术用于肥胖症合并2型糖尿病的效果[J]. 中华普外科手术学杂志(电子版), 2024, 18(02): 150-154.
[7] 颜帅, 胡旭, 苟晓梅, 谢铭. 腹腔镜胃袖状切除术后并发症处置策略[J]. 中华普外科手术学杂志(电子版), 2024, 18(02): 220-224.
[8] 纪凯伦, 郝少龙, 孙海涛, 韩威. 减重术后胆囊结石形成机制的新进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 100-103.
[9] 陈大敏, 曹晓刚, 曹能琦. 肥胖对胃癌患者手术治疗效果的影响研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 651-653.
[10] 张洪, 王宏宇. 神经酰胺与心脏和血管疾病关系的研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(11): 1202-1205.
[11] 薛念余, 张盛敏, 吴凌恒, 沙蕾, 童揽月, 沈崔琴, 李朝军, 杜联芳. 研究血清胆红素对2型糖尿病患者心脏结构发生改变前心肌功能的影响[J]. 中华临床医师杂志(电子版), 2023, 17(09): 1004-1009.
[12] 王林源, 熊鑫, 杨坤, 邓勇志. 基于冠状动脉CT血管成像的影像组学列线图鉴别诊断易损斑块的价值[J]. 中华诊断学电子杂志, 2024, 12(01): 1-8.
[13] 郑欣雅, 邱宝山, 王伊龙. 血栓炎症在缺血性卒中发生发展机制中的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(06): 533-538.
[14] 辛伽伦, 袁兴运, 刘志勤, 师瑞, 蒋锋, 刘锋昌, 李伟旺, 张恒, 郭强, 何剑波, 姚力. 药物洗脱支架在急性大脑中动脉粥样硬化闭塞性卒中患者急诊血管成形术中的临床疗效[J]. 中华脑血管病杂志(电子版), 2023, 17(06): 539-544.
[15] 刘英, 马利军, 王宝军, 刘晓林, 柴圣婷, 苏宁. 颅内动脉粥样硬化斑块成分及特征与缺血性脑卒中相关性的HRMR-VWI研究[J]. 中华脑血管病杂志(电子版), 2023, 17(06): 549-556.
阅读次数
全文


摘要