肥胖与骨质疏松关系的研究进展

doi:10.3877/cma.j.issn.2095-9605.2022.04.010

伴随人口老龄化以及生活方式变化，肥胖、骨质疏松等慢性病的发病率持续走高，已成为威胁居民健康的重大公共卫生问题。研究报道肥胖与骨质疏松之间存在密切关联，潜在的调控机制复杂。本文将从流行病学调查以及细胞分子机制两个层面对肥胖和骨质疏松关联情况进行综述，进一步阐明肥胖影响骨骼健康的重要因素（图1），并初步探讨脂肪组织和骨骼系统互相影响的重要途径（图2），为开展共患人群健康管理和临床研究提供理论依据。

关键词: 肥胖, 超重, 骨质疏松, 骨折

With the aging of the population and changes in lifestyle, the incidence of chronic diseases such as obesity and osteoporosis continues to rise, which has become a major public health problem that threatens the health of residents. Studies have reported a close relationship between obesity and osteoporosis, and the underlying regulatory mechanisms are complex. This article will review the relationship between obesity and osteoporosis from two levels of epidemiological investigation and cellular and molecular mechanisms, further clarify the important factors that obesity affects bone health (Figure 1), and preliminarily explore the mutual influence of adipose tissue and skeletal system (Figure 2), providing a theoretical basis for health management and clinical research of comorbid populations.

Key words: Obesity, Overweight, Osteoporosis, Fractures

图1 肥胖影响骨骼健康的保护因素和不利因素

图2 肥胖影响骨质疏松发生的重要途径

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Research progress on the relationship between obesity and osteoporosis

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Research progress on the relationship between obesity and osteoporosis