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中华肥胖与代谢病电子杂志 ›› 2022, Vol. 08 ›› Issue (04) : 231 -235. doi: 10.3877/cma.j.issn.2095-9605.2022.04.003

论著

代谢综合征与端粒状态对结直肠癌患者预后的影响
刘仕锦1, 张怡然1, 丁晖1, 赵晓旭1,(), 潘运龙1,()   
  1. 1. 510630 广州,暨南大学附属第一医院普通外科
  • 收稿日期:2022-11-01 出版日期:2022-11-30
  • 通信作者: 赵晓旭, 潘运龙
  • 基金资助:
    广东省基础与应用基础研究基金(2020A1515110639)

Metabolic syndrome and telomere status in the prognosis of patients with colorectal cancer

Shijin Liu1, Yiran Zhang1, Hui Ding1, Xiaoxu Zhao1,(), Yunlong Pan1,()   

  1. 1. Department of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • Received:2022-11-01 Published:2022-11-30
  • Corresponding author: Xiaoxu Zhao, Yunlong Pan
引用本文:

刘仕锦, 张怡然, 丁晖, 赵晓旭, 潘运龙. 代谢综合征与端粒状态对结直肠癌患者预后的影响[J/OL]. 中华肥胖与代谢病电子杂志, 2022, 08(04): 231-235.

Shijin Liu, Yiran Zhang, Hui Ding, Xiaoxu Zhao, Yunlong Pan. Metabolic syndrome and telomere status in the prognosis of patients with colorectal cancer[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(04): 231-235.

目的

探索代谢综合征(MetS)和端粒状态对结直肠癌(CRC)患者预后的影响。

方法

回顾性分析2014年1月1日至2016年12月31日在暨南大学附属第一医院普外科并符合纳入标准的256名CRC患者。

结果

MetS组和非MetS组患者的临床特征中存在显著差异的有T分期(P=0.047)、M分期(P=0.043)和临床分期(P=0.043),而性别、肿瘤部位和N分期的差异则无统计学意义。另外,端粒平均长度和端粒酶活性均与M分期相关。最后,通过Kaplan-Meier生存分析和COX回归分析发现影响CRC患者预后的因素包括M分期(HR=2.695,95%CI: 1.715-4.236)、临床分期(HR=5.345,95%CI:3.216-8.883)、代谢综合征(HR=1.552,95%CI: 1.053-2.289)。

结论

伴有MetS的CRC患者的预后较差,提示了通过控制血压、胰岛素抵抗、体重等MetS的组成成分,可能改善CRC患者的预后。

Objective

To explore the impact of metabolic syndrome (MetS) and telomere status on the prognosis of patients with colorectal cancer (CRC).

Methods

A retrospective analysis of 256 patients with CRC who met the inclusion criteria in the Department of General Surgery at the First Hospital of Jinan University from January 1, 2014 to December 31, 2016.

Results

The significant differences in clinical characteristics between patients in the MetS and non-MetS groups were T stage (P=0.047), M stage (P=0.043) and clinical stage (P=0.043), while the differences in gender, tumor site and N stage were not statistically significant. In addition, both mean telomere length and telomerase activity were correlated with theM stage. Finally, Kaplan-Meiersurvival analysis and COX regression analysis revealed important factors on the prognosis of CRC patients including M stage (HR=2.695, 95% CI: 1.715-4.236), clinical stage (HR=5.345, 95% CI: 3.216-8.883), metabolic syndrome (HR=1.552, 95%CI: 1.053-2.289).

Conclusions

The prognosis of CRC patients with MetS is poor. This indicates that the prognosis of patients may be improved by controlling the components of MetS such as blood pressure, insulin resistance and body weight.

表1 CRC患者的临床特征(n=256)
表2 MetS与CRC患者临床特征的关系(n,%)
表3 CRC患者的端粒状态和临床特征的关系
图1 MetS组和非MetS组CRC患者OS的比较
表4 影响CRC患者预后的单因素和多因素分析
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