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中华肥胖与代谢病电子杂志 ›› 2022, Vol. 08 ›› Issue (04) : 225 -230. doi: 10.3877/cma.j.issn.2095-9605.2022.04.002

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GLP-1RA类药物在减重治疗中的临床应用效果
何明1, 程俊铭1, 张源1, 孔祥鑫1, 宋可1, 任亦星1,()   
  1. 1. 637000 南充,川北医学院附属医院胃肠外一科;川北医学院肝胆胰肠研究所
  • 收稿日期:2022-10-30 出版日期:2022-11-30
  • 通信作者: 任亦星
  • 基金资助:
    国家自然科学基金面上项目(82070535); 南充市校科技战略合作专项(20SXQT0312); 南充市校科技战略合作专项(22SXQT0126)

Clinical effectiveness of GLP-1RA class drugs in weight reduction treatment.

Ming He1, Junming Chen1, Yuan Zhang1, Xiangxin Kong1, Ke Song1, Yixing Ren1,()   

  1. 1. Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College; Institute of Hepatobiliary, Pancreatic and Gastroenterology, North Sichuan Medical College, Nanchong 637000, China
  • Received:2022-10-30 Published:2022-11-30
  • Corresponding author: Yixing Ren
引用本文:

何明, 程俊铭, 张源, 孔祥鑫, 宋可, 任亦星. GLP-1RA类药物在减重治疗中的临床应用效果[J/OL]. 中华肥胖与代谢病电子杂志, 2022, 08(04): 225-230.

Ming He, Junming Chen, Yuan Zhang, Xiangxin Kong, Ke Song, Yixing Ren. Clinical effectiveness of GLP-1RA class drugs in weight reduction treatment.[J/OL]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(04): 225-230.

肥胖及其代谢相关问题目前已经成为临床治疗上的热点问题。胰高糖素样肽-1受体激动剂(glucagon-like peptide-1 receptor agonists,GLP-1RA)是近年来的新型降糖药,可通过激活GLP-1受体,以葡萄糖浓度依赖的方式增强胰岛素分泌,抑制胰高糖素分泌,同时能够延缓胃排空,通过中枢性的食欲抑制减少进食量,从而达到降低血糖、减轻体重、改善代谢。近年来已有报道GLP-1RA运用于临床减重及降糖,GLP-1RA是否可以在临床中代替减重手术,目前还处于未知。本文探讨GLP-1RA在减重中的临床应用效果。

Obesity and its metabolic problems have become a hot topic in clinical treatment. Glucagon-like peptide-1 receptor agonists (GLP-1RA) are new hypoglycemic drugs in recent years, which can enhance insulin secretion and inhibit Glucagon secretion in a glucose concentration-dependent manner by activating GLP-1 receptor. At the same time, it can delay gastric empting, reduce food intake through central appetite suppression, so as to reduce blood glucose, reduce body weight and improve metabolism. In recent years, GLP-1RA has been reported to be used in clinical weight loss and hypoglycemia. Whether GLP-1RA can replace bariatric surgery in clinical practice is still unknown. This article will review the clinical application effect of GLP-1RA in weight loss.

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